公开(公告)号：WO2007134168A3

公开(公告)日：2008-01-24

申请号：PCT/US2007068667

申请日：2007-05-10

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  GUDIPATI SRINIVASALU ,  KATKAM SRINIVAS ,  PITTA JAYA PRAKASH ,  GANJI PRASAD ,  CHALLA NAGESWARA RAO

Inventor： GUDIPATI SRINIVASALU ,  KATKAM SRINIVAS ,  PITTA JAYA PRAKASH ,  GANJI PRASAD ,  CHALLA NAGESWARA RAO

IPC: C07D333/12 ,  C07D333/20 ,  C07D333/22

CPC classification number: C07D333/16

Abstract: A process for preparing duloxetine or a salt thereof.

Abstract translation: 一种制备度洛西汀或其盐的方法。

公开(公告)号：WO2007120263A3

公开(公告)日：2007-12-21

申请号：PCT/US2006060767

申请日：2006-11-10

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  KATKAM SRINIVAS ,  KOMATI SATYANARAYANA ,  GUDIPATI SRINIVASULU ,  PITTA JAYAPRAKASH ,  CHALLA NAGESWARA RAO ,  BUCCHIKONDLA RAVINDER ,  MALLINA SRINIVASA RAO ,  GOLDWYN ADOLF CEASER ,  KHARKAR MANOJ RAMESH ,  NARSAPUR SHARAT PANDURANG ,  MADDULA SRINIVASULA REDDY ,  KASULA RAMAMURTHY ,  LALI ARVIND MALLINATH ,  KALE SANDEEP BHASKAR ,  BHORI ABIJAR JOYEBBHAI

Inventor： KATKAM SRINIVAS ,  KOMATI SATYANARAYANA ,  GUDIPATI SRINIVASULU ,  PITTA JAYAPRAKASH ,  CHALLA NAGESWARA RAO ,  BUCCHIKONDLA RAVINDER ,  MALLINA SRINIVASA RAO ,  GOLDWYN ADOLF CEASER ,  KHARKAR MANOJ RAMESH ,  NARSAPUR SHARAT PANDURANG ,  MADDULA SRINIVASULA REDDY ,  KASULA RAMAMURTHY ,  LALI ARVIND MALLINATH ,  KALE SANDEEP BHASKAR ,  BHORI ABIJAR JOYEBBHAI

IPC: C07D221/18

CPC classification number: C07D221/18

Abstract: Dutasteride having low concentrations of impurities, such as dihydrodutasteride and desmethyldutasteride, and processes for purifying dutasteride.

Abstract translation: 具有低浓度杂质的度他雄胺，例如二氢他雄胺和去甲基去量他雄胺，以及纯化度他雄胺的方法。

公开(公告)号：WO2012146980A3

公开(公告)日：2012-12-27

申请号：PCT/IB2012000922

申请日：2012-04-27

Applicant: REDDYS LAB LTD DR ,  KATKAM SRINIVAS ,  SAGYAM RAJESWAR REDDY ,  MORTHALA RAGHAVENDAR RAO ,  IRENI BABU ,  VINIGARI KRISHNA ,  RAMDOSS SURESH KUMAR ,  RANGINENI SRINIVASULU ,  TUMMALA ARJUNKUMAR ,  IQBAL JAVED ,  ORUGANTI SRINIVAS ,  KANDAGATLA BHASKAR

Inventor： KATKAM SRINIVAS ,  SAGYAM RAJESWAR REDDY ,  MORTHALA RAGHAVENDAR RAO ,  IRENI BABU ,  VINIGARI KRISHNA ,  RAMDOSS SURESH KUMAR ,  RANGINENI SRINIVASULU ,  TUMMALA ARJUNKUMAR ,  IQBAL JAVED ,  ORUGANTI SRINIVAS ,  KANDAGATLA BHASKAR

IPC: C07C211/00 ,  C07D333/20

CPC classification number: C07C205/45 ,  C07C201/10 ,  C07C201/12 ,  C07C213/00 ,  C07C213/02 ,  C07C213/10 ,  C07C215/28 ,  C07C205/04

Abstract: The present application provide processes for the preparation of fingolimod and its pharmaceutically acceptable salts, process for the purification of fingolimod hydrochloride and process for the preparation of amorphous fingolimod hydrochloride.

Abstract translation: 本申请提供了芬戈莫德及其药学上可接受的盐的制备方法，盐酸芬戈莫德的纯化方法和用于制备无定形芬戈莫德盐酸盐的方法。

公开(公告)号：WO2008100651A3

公开(公告)日：2008-11-20

申请号：PCT/US2008050388

申请日：2008-01-07

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  KATKAM SRINIVAS ,  VADDADI PATTABHIRAMAYYA ,  SUNKARA VISHNUVARDHAN ,  MUTTAVARAPU MURALIMOHAN ,  KULKARNI LALITHA DATTATRAY ,  SAGYAM RAJESHWAR REDDY ,  PITTA JAYA PRAKASH ,  BUCHNIKONDA RAVINDER ,  MUNAGALA SRIDHAR

Inventor： KATKAM SRINIVAS ,  VADDADI PATTABHIRAMAYYA ,  SUNKARA VISHNUVARDHAN ,  MUTTAVARAPU MURALIMOHAN ,  KULKARNI LALITHA DATTATRAY ,  SAGYAM RAJESHWAR REDDY ,  PITTA JAYA PRAKASH ,  BUCHNIKONDA RAVINDER ,  MUNAGALA SRIDHAR

IPC: C07D207/06 ,  C07D307/79 ,  C07D405/06

CPC classification number: C07D405/06 ,  C07D307/79

Abstract: Provided are various processes and compounds related to darifenacin and/or its salts. For example, there is provided a process for preparing a free base of darifenacin: Formula, or the salt thereof, the process including reacting 3-(S)-(cyanodiphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl) ethyl] pyrrolidine of the Formula (IV), or a salt thereof: Formula (IV) with a base effective to convert the nitrile group of the compound of the Formula (IV) to the amide group of the darifenacin in an organic solvent, the reaction being carried out in the organic solvent, with a proviso that the solvent is not 2-methyl-butan-2-ol, and with further proviso that the reaction produces less than about 0.5 % of the compound of the Formula (Ic): Formula (Ic) in the reaction mass, as measured by HPLC. Various embodiments and variants are provided.

Abstract translation: 提供与darifenacin和/或其盐相关的各种方法和化合物。 例如，提供了制备达赖芬那定游离碱的方法：式（或其盐）的方法包括使3-（S） - （氰基二苯基甲基）-1- [2-（2,3-二氢苯并呋喃-5-基） - 基）乙基]吡咯烷或其盐：具有有效将式（Ⅳ）化合物的腈基转化为darifenacin的酰胺基的有机基团的式（Ⅳ） 溶剂，反应在有机溶剂中进行，条件是溶剂不是2-甲基 - 丁-2-醇，另外条件是反应产生小于约0.5％的式（ Ic）：通过HPLC测量的反应物质中的式（Ic）。 提供了各种实施例和变型。

公开(公告)号：WO2012106584A2

公开(公告)日：2012-08-09

申请号：PCT/US2012023745

申请日：2012-02-03

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  KVS RAMA RAO ,  KATKAM SRINIVAS ,  SAGYAM RAJESWAR REDDY ,  PITTA JAYAPRAKASH ,  MUNAGALA SRIDHAR ,  PEDDY VISHWESHWAR ,  TUMMALA ARJUN KUMAR ,  RAGINENI SRINIVASULU ,  DOOSA HIMA BINDU

Inventor： KVS RAMA RAO ,  KATKAM SRINIVAS ,  SAGYAM RAJESWAR REDDY ,  PITTA JAYAPRAKASH ,  MUNAGALA SRIDHAR ,  PEDDY VISHWESHWAR ,  TUMMALA ARJUN KUMAR ,  RAGINENI SRINIVASULU ,  DOOSA HIMA BINDU

IPC: C07D215/12 ,  A61K31/47 ,  A61P3/06 ,  C07D215/14

CPC classification number: C07D215/14

Abstract: The present disclosure includes salt of pitavastatin, and processes for their preparation and isolation. It further relates to crystalline forms of pitavastatin salts and hydrates thereof, and process for preparing an amorphous form of pitavastatin

Abstract translation: 本发明包括匹伐他汀的盐及其制备和分离的方法。 它还涉及匹伐他汀盐及其水合物的结晶形式，以及制备无定形形式的匹伐他汀的方法

公开(公告)号：WO2011091131A3

公开(公告)日：2011-12-22

申请号：PCT/US2011021852

申请日：2011-02-08

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  KATKAM SRINIVAS ,  SAGYAM RAJESHWAR REDDY ,  BUCHIKONDA RAVINDER ,  MUTTAVARAPU MURALI MOHAN ,  MUNAGALA SRIDHAR ,  CHIKKA RAMBABU

Inventor： KATKAM SRINIVAS ,  SAGYAM RAJESHWAR REDDY ,  BUCHIKONDA RAVINDER ,  MUTTAVARAPU MURALI MOHAN ,  MUNAGALA SRIDHAR ,  CHIKKA RAMBABU

IPC: C07D223/24 ,  A61K31/55 ,  C07D223/28

CPC classification number: A61K31/55 ,  C07D223/24 ,  C07D223/28

Abstract: Processes for the preparation of eslicarbazepine acetate and intermediates thereof. Also provided are polymorphic forms of eslicarbazepine acetate and methods for their preparation.

Abstract translation: 制备乙酸西酞西泮及其中间体的方法。 还提供了醋酸西沙比齐的多晶型形式及其制备方法。

公开(公告)号：WO2010056656A3

公开(公告)日：2010-08-19

申请号：PCT/US2009063846

申请日：2009-11-10

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  KATKAM SRINIVAS ,  SAGYAM RAJESHWAR REDDY ,  SUNKARA VISHNUVARDHAN ,  MUNAGALA SRIDHAR ,  MUTTAVARAPU MURALI MOHAN

Inventor： KATKAM SRINIVAS ,  SAGYAM RAJESHWAR REDDY ,  SUNKARA VISHNUVARDHAN ,  MUNAGALA SRIDHAR ,  MUTTAVARAPU MURALI MOHAN

IPC: C07D453/02 ,  C07D401/14 ,  C07D403/14 ,  C07D487/08

CPC classification number: C07D453/02

Abstract: Processes for the preparation of palonosetron hydrochloride and its crystalline forms.

Abstract translation: 制备盐酸帕洛诺司琼及其结晶形式的方法。

公开(公告)号：WO2015044876A8

公开(公告)日：2015-12-03

申请号：PCT/IB2014064797

申请日：2014-09-24

Applicant: REDDYS LAB LTD DR

Inventor： KATKAM SRINIVAS ,  GANDAVADI SUNIL KUMAR ,  NARIYAM MUNASWAMY SEKHAR ,  BOINI AMBAIAH ,  BOCHHA RAMESH ,  TIRUNAGARI VIJAY KUMAR ,  KOMARAVOLU YAGNA KIRAN KUMAR ,  GANJI BALA HARSHA VARDHAN ,  KOLA LAVANYA

IPC: C08F210/00 ,  C07K14/00

CPC classification number: C07K14/001 ,  C07K2/00 ,  C08G69/10

Abstract: The present invention provides trifluoroacetyl copolymers useful as standard molecular weight markers in the intermediary stage for obtaining glatiramer acetate having desired average molecular weight. The present invention further provides a process for determining the average molecular weight of glatiramer acetate or other copolymers using molecular weight markers of protected polypeptides.

Abstract translation: 本发明提供在中间阶段用作标准分子量标记的三氟乙酰基共聚物，用于获得具有所需平均分子量的醋酸格拉默。 本发明还提供了使用保护的多肽的分子量标记物来确定乙酸格拉默或其它共聚物的平均分子量的方法。

公开(公告)号：WO2011159903A3

公开(公告)日：2012-05-24

申请号：PCT/US2011040710

申请日：2011-06-16

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  KATKAM SRINIVAS ,  POLAVARAPU SRINIVAS ,  YADDANAPUDI VENKATA MADHAVI ,  VINIGARI KRISHNA ,  PAGADALA NARASIMHA RAO ,  SAGYAM RAJESHWAR REDDY

Inventor： KATKAM SRINIVAS ,  POLAVARAPU SRINIVAS ,  YADDANAPUDI VENKATA MADHAVI ,  VINIGARI KRISHNA ,  PAGADALA NARASIMHA RAO ,  SAGYAM RAJESHWAR REDDY

IPC: C07D491/044 ,  A61K31/407 ,  A61P25/18

CPC classification number: C07D491/04 ,  C07D491/044

Abstract: Aspects of the present application relate to a microcrystalline monoclinic form of asenapine maleate represented by structural Formula (I); processes for its preparation; and pharmaceutically acceptable dosage forms thereof.

Abstract translation: 本申请的方面涉及由结构式（I）表示的微晶单斜晶形式的马来酸asenapine; 其准备过程; 及其药学上可接受的剂型。

公开(公告)号：WO2006039441A3

公开(公告)日：2006-07-20

申请号：PCT/US2005035094

申请日：2005-09-29

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  GUDIPATI SRINIVASULU ,  KATKAM SRINIVAS ,  KOMATI SATYANARAYANA ,  KUDAVALLI SATYANARAYANA JAYA

Inventor： GUDIPATI SRINIVASULU ,  KATKAM SRINIVAS ,  KOMATI SATYANARAYANA ,  KUDAVALLI SATYANARAYANA JAYA

IPC: A61K31/22

CPC classification number: A61K31/401 ,  C07D207/34

Abstract: Amorphous atorvastatin calcium having an enhanced stability contains about 2 to about 8 percent by weight water. A process for preparing the amorphous atorvastatin calcium and a packaging system for maintaining the stability are described.

Abstract translation: 具有增强的稳定性的无定形阿托伐他汀钙含有约2至约8重量％的水。 描述了制备无定形阿托伐他汀钙的方法和用于维持稳定性的包装系统。