公开(公告)号：EP2284519A4

公开(公告)日：2014-04-23

申请号：EP08752781

申请日：2008-05-15

Applicant: SHIMADZU CORP

Inventor： ODA ICHIRO ,  YAJIMA ATSUSHI ,  HIZUME KENTARO ,  MEGA AKIMASA ,  KAMIKAKE TADAFUMI ,  KURATANI YUTAKA ,  FUJITA TAKESHI ,  TSUNAZAWA YOSHIO

IPC: G01N21/64 ,  G01N21/76 ,  G06T1/00 ,  H04N5/225 ,  H04N13/02

CPC classification number: G01N21/6456 ,  G01N21/6486 ,  G01N21/763 ,  H04N5/2254 ,  H04N13/0217

Abstract: Optical waveguide paths to observe a sample on a sample holder from a plurality of directions while guiding an image of light in each direction which is emitted out of the sample toward a direction of a two dimensional detector via a main imaging lens include an optical waveguide path which never receives the light directly from the sample. The optical waveguide path which never receives the light directly from the sample forms an image of the sample within a substantial focus range of the main imaging lens, and includes optical elements arranged such that a light beam after formation of the image proceeds toward a direction of the main imaging lens. Optical elements on at least one optical waveguide path are those for forming real images. Therefore, the main imaging lens images the sample and those real images in block on the two dimentional detector.

公开(公告)号：EP2333524A4

公开(公告)日：2013-03-27

申请号：EP08810908

申请日：2008-09-18

Applicant: SHIMADZU CORP

Inventor： YAJIMA ATSUSHI ,  ODA ICHIRO ,  HIZUME KENTARO ,  TSUNAZAWA YOSHIO

IPC: G01N21/64 ,  G01J3/44 ,  G02B5/20 ,  G02B21/00

CPC classification number: G01N21/6458 ,  A61B5/0059 ,  G01J3/4406 ,  G01J2003/1226 ,  G01N21/6428 ,  G01N2021/6471 ,  G01N2201/0612 ,  G01N2201/064 ,  G02B5/285 ,  G02B21/0032 ,  G02B21/0076

公开(公告)号：JP2009016702A

公开(公告)日：2009-01-22

申请号：JP2007179366

申请日：2007-07-09

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： YAJIMA ATSUSHI

IPC: H01S3/137 ,  G02B5/20

Abstract: PROBLEM TO BE SOLVED: To improve a yield and to make temperature tuning width narrow.
SOLUTION: This birefringent filter (10) includes an optical element (14) with transmission different in accordance with a polarization direction and SLT birefringent crystal (15) using lithium tantalate (LiTaO3) having a stoichiometric composition, and the birefringent filter (10) is inserted into an optical resonator (17). As a result, since wavelength tuning width determined by the lithium tantalate (SLT) having the stoichiometric composition is larger than wavelength tuning width determined by the conventional yttrium vanadate (YVO4), the SLT birefringent crystal (15) can be made thick. Therefore, the allowable error of a thickness becomes large, precision required for working is made lower, and a yield can be improved. Since temperature-wavelength change rate is high in the SLT birefringent crystal (15), temperature tuning width can be made narrow.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提高产量并使温度调节宽度变窄。 解决方案：该双折射滤光器（10）包括使用具有化学计量组成的钽酸锂（LiTaO 3）和根据偏光方向的双折射滤光片（15）的透射不同的光学元件（14）和SLT双折射晶体（15） 10）插入到光谐振器（17）中。 结果，由于由具有化学计量组成的钽酸锂（SLT）确定的波长调谐宽度大于由常规的钒酸钇（YVO4）确定的波长调谐宽度，所以可以使SLT双折射晶体（15）变厚。 因此，厚度的容许误差变大，加工所需的精度降低，成品率提高。 由于SLT双折射晶体（15）中的温度波长变化率高，因此可以使温度调节宽度变窄。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2009257777A

公开(公告)日：2009-11-05

申请号：JP2008103759

申请日：2008-04-11

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： ODA ICHIRO ,  YAJIMA ATSUSHI ,  HASHIZUME KENTARO ,  TSUNASAWA YOSHIO

IPC: G01N21/64

Abstract: PROBLEM TO BE SOLVED: To provide a fluorescence imaging device for imaging in a condition corresponding to a position of a portion to be measured in a biosample.
SOLUTION: An imaging part 2 includes a two-dimensional detector or an optical system for guiding light of an image of the biosample 4 into the two-dimensional detector. A light source device 6 irradiates excitation light selectively from a plurality of mutually different directions to the biosample 4. An imaging operation of the imaging part 2 or a light irradiation operation of the light source device 6 is controlled by a control part 8. An imaging condition setting part 14 for setting an observation direction in which imaging is performed by an operator or an irradiation direction of the excitation light as an imaging condition is provided. The control part 8 controls the imaging part 2 or the light source device 6 so that imaging is performed in the imaging condition set by the imaging condition setting part 14.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于在与生物样品中待测量部分的位置相对应的条件下成像的荧光成像装置。 解决方案：成像部件2包括用于将生物样品4的图像的光引导到二维检测器中的二维检测器或光学系统。 光源装置6从多个相互不同的方向选择性地将激发光照射到生物样品4.成像部2的成像操作或光源装置6的光照射操作由控制部8控制。成像 提供用于设置由操作者进行成像的观察方向的条件设定部14或作为成像条件的激发光的照射方向。 控制部分8控制成像部分2或光源装置6，以便在由成像条件设置部分14设置的成像条件下执行成像。（C）2010，JPO＆INPIT

公开(公告)号：JP2009229290A

公开(公告)日：2009-10-08

申请号：JP2008075997

申请日：2008-03-24

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： YAJIMA ATSUSHI ,  HIZUME KENTARO ,  ODA ICHIRO ,  TSUNASAWA YOSHIO

IPC: G01N21/01 ,  A61B10/00 ,  G01N21/17 ,  G01N21/64 ,  G03B15/00

Abstract: PROBLEM TO BE SOLVED: To provide a biological image acquisition apparatus capable of performing multi-directional and simultaneous observations and measurements in a short time and to provide a sample holding apparatus for implementing the biological image acquisition apparatus. SOLUTION: A sample holding member 2 is supported by a supporting mechanism 12. The supporting mechanism 12 supports a pair of opposed end parts of the sample holding member 2. Gaps 14 are provided between unsupported end parts of the sample holding member 2 and the supporting mechanism 12. The gaps 14 are light-passing regions for passing reflected light from reflecting mirrors M3 and M4 on the back side of the sample holding member 2. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 解决的问题：提供能够在短时间内执行多方向同时观测和测量并提供用于实施生物图像获取装置的样本保持装置的生物图像获取装置。 解决方案：样品保持构件2由支撑机构12支撑。支撑机构12支撑样品保持构件2的一对相对端部。间隙14设置在样品保持构件2的未支撑的端部之间 间隙14是用于使来自反射镜M3和M4的反射光通过样品保持构件2背面的光通过区域。（C）2010，JPO＆INPIT

公开(公告)号：JP2013238498A

公开(公告)日：2013-11-28

申请号：JP2012111940

申请日：2012-05-15

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： IKEHARA TATSUYA ,  ODA ICHIRO ,  YAJIMA ATSUSHI ,  HIZUME KENTARO

IPC: G01N21/64 ,  G01B11/24

Abstract: PROBLEM TO BE SOLVED: To reduce calculation cost while maintaining calculation accuracy in creating a fluorescent image using an optical diffusion equation.SOLUTION: An image processing device 2 includes: a forward problem analysis part 10 that theoretically calculates light propagation analysis for excitation light in a sample and fluorescent light by finite element analysis of an optical diffusion equation; and an inverse problem analysis part 20 that creates a fluorescent image of the inside of the sample, on the basis of three-dimensional surface shape data, fluorescence measurement data, and a result in the forward problem analysis part 10. The forward problem analysis part 10 includes: a mesh size deriving part 12 that derives an optimum mesh size for the finite element analysis of the sample from a specific conditional expression; and an excitation light intensity correction part 14 that corrects excitation light intensity for each mesh of the derived mesh size, by use of the three-dimensional surface shape data and an additionally determined irradiation distribution measurement value of the excitation light. The inverse problem analysis part 20 creates a fluorescent image by means of the mesh size determined in the forward problem analysis part 10 and the corrected excitation light intensity.

Abstract translation: 要解决的问题：降低计算成本，同时保持使用光学扩散方程产生荧光图像的计算精度。解决方案：图像处理装置2包括：正向问题分析部分10，其理论上计算激发光的光传播分析 样品和荧光灯通过光学扩散方程的有限元分析; 以及基于三维表面形状数据，荧光测量数据以及正向问题分析部10中的结果，生成样品内部的荧光图像的逆问题分析部20。正向问题分析部 10包括：网格尺寸导出部分12，其针对来自特定条件表达式的样本的有限元分析导出最佳网格尺寸; 以及通过使用三维表面形状数据和另外确定的激发光的照射分布测量值来校正衍生的网格尺寸的每个网格的激发光强度的激发光强度校正部分14。 反问题分析部20通过在前向问题分析部10中确定的网格尺寸和校正的激发光强度来生成荧光图像。

公开(公告)号：JP2007184384A

公开(公告)日：2007-07-19

申请号：JP2006000989

申请日：2006-01-06

Applicant: Shimadzu Corp ,  株式会社島津製作所

Inventor： YAJIMA ATSUSHI

IPC: H01S3/086 ,  H01S3/081 ,  H01S3/094

Abstract: PROBLEM TO BE SOLVED: To provide an optical resonator block capable of correctly controlling an installation angle of a solid-state laser crystal, and to provide a solid-state laser device. SOLUTION: The optical resonator block includes: the solid-state laser crystal (4) excited by excitation light (L1) to generate laser light (L2), and acting as a surface to which the excitation light (L1) is incident as a reflective surface for reflecting the laser light (L2); an output mirror (6) for forming an optical resonator with the reflective surface of the laser crystal (4); and loopback mirrors (5a and 5b) interposed between the laser crystal (4) and the output mirror (6) for redirectioning the laser light (L2), and has an adjustment hole (17c) bored on a back wall of the loopback mirror (5a) for supporting the mirror (5a) to which the laser light (L2) emitted from the crystal (4) comes first incident. As a result, a pilot beam can be put through the adjustment hole (17c) before installing the mirror (5a) to control the angle of the solid-state laser crystal (4). COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供一种能够正确地控制固态激光晶体的安装角度并提供固态激光器件的光学谐振器块。 解决方案：光学谐振器块包括：由激发光（L1）激发以产生激光（L2）的激光（L1）入射的表面的固态激光晶体（4） 作为用于反射激光（L2）的反射面; 用于形成具有激光晶体（4）的反射表面的光学谐振器的输出镜（6）; 以及插入在激光晶体（4）和输出反射镜（6）之间用于重新定向激光（L2）的回送镜（5a和5b），并且具有在环回镜的后壁上钻孔的调节孔（17c） 5a），用于支撑从晶体（4）发射的激光（L2）首先入射的反射镜（5a）。 结果，在安装反射镜（5a）以控制固态激光晶体（4）的角度之前，可以将调光孔（17c）穿过调节孔（17c）。 版权所有（C）2007，JPO＆INPIT