公开(公告)号：US11433141B2

公开(公告)日：2022-09-06

申请号：US16320587

申请日：2017-07-25

Applicant: SHIZUOKA PREFECTURE

Inventor： Yasuto Akiyama ,  Akira Iizuka

IPC: A61K47/69 ,  A61K47/68 ,  A61P35/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/46 ,  A61K39/00

Abstract: An object is to produce a new anti-B7-H4 antibody having high specificity and affinity and provide a composition for treating cancer making use thereof. A monoclonal antibody that specifically binds to an extracellular domain protein of a human B7-H4 protein is newly produced and an “anti-B7-H4 antibody-effector cell complex” in which the monoclonal antibody and an effector cell are bound in order to enhance the antibody-dependent cellular cytotoxicity of the monoclonal antibody or a bispecific antibody comprising an antigen recognition region of the monoclonal antibody and an effector cell antigen recognition region is further produced and used as a composition for treating cancer.