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公开(公告)号：WO2015081294A2
公开(公告)日：2015-06-04
申请号：PCT/US2014067764
申请日：2014-11-26
Applicant: STC UNM , BRUECK STEVEN R J , EDWARDS JEREMY SCOTT , NEUMANN ALEXANDER , KUZNETSOVA YULIYA , MENDOZA EDGAR A
Inventor： BRUECK STEVEN R J , EDWARDS JEREMY SCOTT , NEUMANN ALEXANDER , KUZNETSOVA YULIYA , MENDOZA EDGAR A
CPC classification number: G01N33/48721 , B01L3/502707 , B01L3/502761 , B01L2200/0663 , B01L2200/0689 , B01L2200/12 , B01L2300/046 , B01L2300/0654 , B01L2300/0816 , B01L2300/087 , B01L2300/0896 , B01L2300/16 , B01L2300/168 , B01L2400/0421 , C12Q1/6869 , C23C16/345 , C23C16/45525 , C23C16/50 , G01N21/65 , G01N2021/653 , G01N2201/061 , C12Q2563/155 , C12Q2565/631
Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (> wavelength), ~ 1-nm aperture "tortuous" nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
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公开(公告)号：WO2015081294A3
公开(公告)日：2015-07-16
申请号：PCT/US2014067764
申请日：2014-11-26
Applicant: STC UNM , BRUECK STEVEN R J , EDWARDS JEREMY SCOTT , NEUMANN ALEXANDER , KUZNETSOVA YULIYA , MENDOZA EDGAR A
Inventor： BRUECK STEVEN R J , EDWARDS JEREMY SCOTT , NEUMANN ALEXANDER , KUZNETSOVA YULIYA , MENDOZA EDGAR A
CPC classification number: G01N33/48721 , B01L3/502707 , B01L3/502761 , B01L2200/0663 , B01L2200/0689 , B01L2200/12 , B01L2300/046 , B01L2300/0654 , B01L2300/0816 , B01L2300/087 , B01L2300/0896 , B01L2300/16 , B01L2300/168 , B01L2400/0421 , C12Q1/6869 , C23C16/345 , C23C16/45525 , C23C16/50 , G01N21/65 , G01N2021/653 , G01N2201/061 , C12Q2563/155 , C12Q2565/631
Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (> wavelength), ~ 1-nm aperture "tortuous" nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
Abstract translation: 长时间读取，无标记，光学纳米孔长链分子测序的方法和设备。 通常，本公开描述了基于纳米通道的整合以提供具有广泛间隔（>波长），〜1nm孔径“曲折”纳米孔的单个长链分子的新型测序技术，其缓慢移位足以提供大量平行的， 使用光学技术的单基准分辨率。 使用简单的胶体纳米颗粒的新颖的定向自组装纳米加工方案用于在展开长链分子的纳米通道上形成纳米孔阵列。 在纳米颗粒阵列的表面，工程等离子体/极化结构中的强定域电磁场允许使用光学技术的单碱基分辨率。
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Patent Agency Ranking
公开(公告)号：EP3074134A4
公开(公告)日：2017-07-12
申请号：EP14865949
申请日：2014-11-26
Applicant: STC UNM
Inventor： BRUECK STEVEN R J , EDWARDS JEREMY SCOTT , NEUMANN ALEXANDER , KUZNETSOVA YULIYA , MENDOZA EDGAR A
CPC classification number: G01N33/48721 , B01L3/502707 , B01L3/502761 , B01L2200/0663 , B01L2200/0689 , B01L2200/12 , B01L2300/046 , B01L2300/0654 , B01L2300/0816 , B01L2300/087 , B01L2300/0896 , B01L2300/16 , B01L2300/168 , B01L2400/0421 , C12Q1/6869 , C23C16/345 , C23C16/45525 , C23C16/50 , G01N21/65 , G01N2021/653 , G01N2201/061 , C12Q2563/155 , C12Q2565/631
Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
Abstract translation: 用于长读取，无标记，光学纳米孔长链分子测序的方法和设备。 通常，本公开内容描述了基于纳米通道整合以递送具有宽间隔（>波长），〜1nm孔径“曲折”纳米孔的单个长链分子的新型测序技术，其缓慢移位足以提供大规模平行， 使用光学技术的单基准分辨率。 使用简单的胶体纳米粒子的新型定向自组装纳米制造方案用于在展开长链分子的纳米通道上形成纳米孔阵列。 在纳米颗粒阵列的表面，工程等离子体激元/极化激元结构中的强局部电磁场允许使用光学技术实现单基极分辨率。
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公开(公告)号：EP3152788A4
公开(公告)日：2018-02-28
申请号：EP15807428
申请日：2015-06-09
Applicant: STC UNM
Inventor： BRUECK STEVEN R J , NEUMANN ALEXANDER , ZARKESH-HA PAYMAN
CPC classification number: G01J1/06 , G01J1/44 , G01J3/0218 , G01J3/0259 , G01J3/18 , G01J3/1895 , G01J3/2803 , G01J2001/448 , G02B6/10 , G02B6/12004 , G02B6/122 , G02B6/124 , H01L27/1446 , H01L31/02019 , H01L31/02164 , H01L31/02327 , H01L31/103
Abstract: A 2-D sensor array includes a semiconductor substrate and a plurality of pixels disposed on the semiconductor substrate. Each pixel includes a coupling region and a junction region, and a slab waveguide structure disposed on the semiconductor substrate and extending from the coupling region to the region. The slab waveguide includes a confinement layer disposed between a first cladding layer and a second cladding layer. The first cladding and the second cladding each have a refractive index that is lower than a refractive index of the confinement layer. Each pixel also includes a coupling structure disposed in the coupling region and within the slab waveguide. The coupling structure includes two materials having different indices of refraction arranged as a grating defined by a grating period. The junction region comprises a p-n junction in communication with electrical contacts for biasing and collection of carriers resulting from absorption of incident radiation.
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公开(公告)号：CA2931784A1
公开(公告)日：2015-06-04
申请号：CA2931784
申请日：2014-11-26
Applicant: STC UNM
Inventor： BRUECK STEVEN R J , EDWARDS JEREMY SCOTT , NEUMANN ALEXANDER , KUZNETSOVA YULIYA , MENDOZA EDGAR A
Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (> wavelength), ~ 1-nm aperture "tortuous" nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.
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公开(公告)号：AU2015274800A1
公开(公告)日：2017-01-05
申请号：AU2015274800
申请日：2015-06-09
Applicant: STC UNM
Inventor： BRUECK STEVEN R J , NEUMANN ALEXANDER , ZARKESH-HA PAYMAN
Abstract: A 2-D sensor array includes a semiconductor substrate and a plurality of pixels disposed on the semiconductor substrate. Each pixel includes a coupling region and a junction region, and a slab waveguide structure disposed on the semiconductor substrate and extending from the coupling region to the region. The slab waveguide includes a confinement layer disposed between a first cladding layer and a second cladding layer. The first cladding and the second cladding each have a refractive index that is lower than a refractive index of the confinement layer. Each pixel also includes a coupling structure disposed in the coupling region and within the slab waveguide. The coupling structure includes two materials having different indices of refraction arranged as a grating defined by a grating period. The junction region comprises a p-n junction in communication with electrical contacts for biasing and collection of carriers resulting from absorption of incident radiation.
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公开(公告)号：CA2951550A1
公开(公告)日：2015-12-17
申请号：CA2951550
申请日：2015-06-09
Applicant: STC UNM
Inventor： BRUECK STEVEN R J , NEUMANN ALEXANDER , ZARKESH-HA PAYMAN
Abstract: A 2-D sensor array includes a semiconductor substrate and a plurality of pixels disposed on the semiconductor substrate. Each pixel includes a coupling region and a junction region, and a slab waveguide structure disposed on the semiconductor substrate and extending from the coupling region to the region. The slab waveguide includes a confinement layer disposed between a first cladding layer and a second cladding layer. The first cladding and the second cladding each have a refractive index that is lower than a refractive index of the confinement layer. Each pixel also includes a coupling structure disposed in the coupling region and within the slab waveguide. The coupling structure includes two materials having different indices of refraction arranged as a grating defined by a grating period. The junction region comprises a p-n junction in communication with electrical contacts for biasing and collection of carriers resulting from absorption of incident radiation.
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