公开(公告)号：EP2007358A2

公开(公告)日：2008-12-31

申请号：EP07754563.0

申请日：2007-04-03

Applicant: STC.UNM

Inventor： SMYTH, Hugh, D. ,  DONOVAN, Martin, J.

IPC: A61K9/22 ,  A61K31/195

CPC classification number: A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/1641 ,  A61K47/60 ,  A61K47/6949 ,  A61K48/00 ,  B82Y5/00 ,  Y10T428/2982

Abstract: Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 µm or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 µm volume mean diameter to retard or prevent their phagocytosis by the macrophages present in airways of the respiratory tract.

公开(公告)号：WO2009070282A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/013112

申请日：2008-11-25

Applicant: STC.UNM ,  SMYTH, Hugh, D. ,  OSINSKI, Marek ,  MCGILL, Shayna, L.

Inventor： SMYTH, Hugh, D. ,  OSINSKI, Marek ,  MCGILL, Shayna, L.

IPC: A61K9/14

CPC classification number: A61K9/0009 ,  A61K9/5094 ,  A61K9/5115 ,  A61K9/7023 ,  A61K41/0052 ,  A61K47/6921 ,  A61K47/6923

Abstract: Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biologial barriers under the influence of a magnetic field.

Abstract translation: 活性多功能纳米颗粒由于在磁场的影响下通过粘液和生物学屏障增加扩散和渗透，从而显着提高模型治疗和基因药物的功效。

公开(公告)号：WO2007123793A3

公开(公告)日：2007-11-01

申请号：PCT/US2007/008058

申请日：2007-04-03

Applicant: STC.UNM ,  SMYTH, Hugh, D. ,  DONOVAN, Martin, J.

Inventor： SMYTH, Hugh, D. ,  DONOVAN, Martin, J.

IPC: A61K9/22 ,  A61K31/195

Abstract: Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 µm or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 µm volume mean diameter to retard or prevent their phagocytosis by the macrophages present in airways of the respiratory tract.