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1.发明公开METHODS AND SYSTEMS FOR DOSING AND COATING INHALATION POWDERS ONTO CARRIER PARTICLES 审中-公开方法和系统剂量与粉吸入剂在载体颗粒涂层
公开(公告)号：EP2470167A2
公开(公告)日：2012-07-04
申请号：EP10815900.5
申请日：2010-08-27
Applicant: STC.UNM
Inventor： SMYTH, Hugh, D.C. , DONOVAN, Martin, J.
CPC classification number: A61K9/0075 , A61K9/14 , A61K31/58
Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.
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公开(公告)号：EP2007358A2
公开(公告)日：2008-12-31
申请号：EP07754563.0
申请日：2007-04-03
Applicant: STC.UNM
Inventor： SMYTH, Hugh, D. , DONOVAN, Martin, J.
IPC: A61K9/22 , A61K31/195
CPC classification number: A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1641 , A61K47/60 , A61K47/6949 , A61K48/00 , B82Y5/00 , Y10T428/2982
Abstract: Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 µm or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 µm volume mean diameter to retard or prevent their phagocytosis by the macrophages present in airways of the respiratory tract.
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公开(公告)号：WO2007123793A3
公开(公告)日：2007-11-01
申请号：PCT/US2007/008058
申请日：2007-04-03
Applicant: STC.UNM , SMYTH, Hugh, D. , DONOVAN, Martin, J.
Inventor： SMYTH, Hugh, D. , DONOVAN, Martin, J.
IPC: A61K9/22 , A61K31/195
Abstract: Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 µm or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 µm volume mean diameter to retard or prevent their phagocytosis by the macrophages present in airways of the respiratory tract.
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4.发明申请METHODS AND SYSTEMS FOR DOSING AND COATING INHALATION POWDERS ONTO CARRIER PARTICLES 审中-公开在载体颗粒上加入和涂覆吸入粉末的方法和系统
公开(公告)号：WO2011031564A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/047043
申请日：2010-08-27
Applicant: STC.UNM , SMYTH, Hugh, D.C. , DONOVAN, Martin, J.
Inventor： SMYTH, Hugh, D.C. , DONOVAN, Martin, J.
CPC classification number: A61K9/0075 , A61K9/14 , A61K31/58
Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.
Abstract translation: 将粉末状药剂涂布在用于干粉吸入器的载体颗粒上的方法的方法可以包括将超声能量施加到附聚的粉末状药剂以将药剂的颗粒分解和雾化成具有所需平均粒径的颗粒，以及涂覆 至少一个具有所需量的药物的解聚集和雾化颗粒的载体颗粒。
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