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    SURGICAL SYSTEM FOR JOINTS
    1.
    发明申请
    SURGICAL SYSTEM FOR JOINTS 审中-公开
    接头外科系统

    公开(公告)号：WO2007008348A2

    公开(公告)日：2007-01-18

    申请号：PCT/US2006023909

    申请日：2006-06-20

    Applicant: STONE HOWARD A ,  BACKES LARRY P

    Inventor： STONE HOWARD A ,  BACKES LARRY P

    IPC: A61B17/58

    CPC classification number: A61B17/683 ,  A61B17/1775 ,  A61B17/562 ,  A61B2017/565

    Abstract: A surgical kit including a surgical guide system for drilling bones at a joint, a surgical implant for attachment to the bones at the joint, and a surgical implant for attachment to the bones at the joint.

    Abstract translation: 一种手术套件，包括用于在关节处钻骨的外科手术引导系统，用于附接到关节处的骨骼的外科植入物，以及用于附接到关节处的骨骼的外科植入物。

    MICROCONCENTRATOR/MICROFILTER
    2.
    发明申请
    MICROCONCENTRATOR/MICROFILTER 审中-公开
    微量浓缩/ MICROFILTER

    公开(公告)号：WO2006079007A3

    公开(公告)日：2006-11-16

    申请号：PCT/US2006002229

    申请日：2006-01-20

    Applicant: HARVARD COLLEGE ,  BALA SUBRAMANIAM ANAND ,  ABKARIAN MANOUK ,  FABRE ADRIEN ,  DURAND MARC ,  STONE HOWARD A

    Inventor： BALA SUBRAMANIAM ANAND ,  ABKARIAN MANOUK ,  FABRE ADRIEN ,  DURAND MARC ,  STONE HOWARD A

    IPC: B01D35/00 ,  B01D15/34 ,  B01D57/00 ,  B01D61/00 ,  B01D63/00

    CPC classification number: B01D63/081 ,  B01D61/18 ,  B01D63/088 ,  B01D67/0034 ,  B01D71/70 ,  B01D2323/24 ,  B01D2325/028 ,  B01L3/5027

    Abstract: The present invention includes a microfluidic filter and concentrator that can separate a filtrate from a fluid containing components, e.g. a suspension of particles, to be removed from the fluid at least to some extent. The filter may employ principals of tangential flow filtration, also known as cross-flow filtration. In one aspect, a microfluidic filter described herein includes at least a first, main channel and one or more secondary, filtering channels that connect to the main channel. Filtration occurs when a fluid portion of a sample that is flowed through the main channel enters one or more of the filtering channels and at least some of the components in the sample do not enter or do not flow through the secondary, filtering channels. The secondary channels may be dimensioned to inhibit flow of components through them, and/or a porous material such as a layer may be positioned to inhibit flow of components through the secondary channels.

    Abstract translation: 本发明包括微流体过滤器和浓缩器，其可以将滤液与含有组分的流体分离，例如， 至少在一定程度上从流体中除去颗粒的悬浮液。 过滤器可以采用切向流过滤的原理，也称为交叉流过滤。 在一个方面，本文描述的微流控滤波器至少包括连接到主通道的第一主通道和一个或多个次级滤波通道。 当流过主通道的样品的流体部分进入一个或多个过滤通道并且样品中的至少一些组分不进入或不流过次级过滤通道时，发生过滤。 次级通道的尺寸可以限制通过它们的部件的流动，和/或诸如层的多孔材料可以被定位成阻止部件通过次级通道的流动。

    FORMATION OF PARTICLES FOR ULTRASOUND APPLICATION, DRUG RELEASE, AND OTHER USES, AND MICROFLUIDIC METHODS OF PREPARATION
    3.
    发明申请
    FORMATION OF PARTICLES FOR ULTRASOUND APPLICATION, DRUG RELEASE, AND OTHER USES, AND MICROFLUIDIC METHODS OF PREPARATION 审中-公开
    用于超声波应用，药物释放和其他用途的颗粒的形成以及微流体制备方法

    公开(公告)号：WO2009048532A2

    公开(公告)日：2009-04-16

    申请号：PCT/US2008011456

    申请日：2008-10-03

    Applicant: HARVARD COLLEGE ,  STONE HOWARD A ,  WAN JIANDI ,  SULLIVAN MATTHEW

    Inventor： STONE HOWARD A ,  WAN JIANDI ,  SULLIVAN MATTHEW

    IPC: A61K47/48 ,  A61K41/00 ,  A61P43/00

    CPC classification number: A61K41/0028 ,  A61K9/0009 ,  A61K9/113 ,  B01F3/0807 ,  B01F13/0062 ,  B01J13/04

    Abstract: The present invention generally relates to emulsions and, in particular, to systems and methods for forming multiple emulsions and emulsions produced therefrom. A multiple emulsion generally describes a larger droplet that contains one or more smaller droplets therein which, in some cases, can contain even smaller droplets therein, etc. Multiple emulsions can be formed in certain embodiments with generally precise repeatability, and can be tailored to include any number of inner droplets, in any desired nesting arrangement, within a single outer droplet. In some cases, one (or more) of the fluids can be a gas. In addition, in some embodiments, the size of the multiple emulsion can be varied.

    Abstract translation: 本发明总体上涉及乳液，并且特别涉及用于形成由其生产的多重乳液和乳液的系统和方法。 多重乳液通常描述其中含有一个或多个较小液滴的较大液滴，其在一些情况下可在其中含有甚至更小的液滴等。在某些实施方案中，可以形成具有通常精确的可重复性的多重乳液，并且可定制为包括 在任何期望的嵌套排列中，在单个外部液滴内的任何数量的内部液滴。 在一些情况下，一种（或多种）流体可以是气体。 另外，在一些实施例中，多重乳液的尺寸可以变化。

    ACTIVE SURFACES, INCLUDING MICROFLUIDICS, DISPLAYS, SENSORS, LIGHT INTERACTION AND CONTROL
    4.
    发明申请
    ACTIVE SURFACES, INCLUDING MICROFLUIDICS, DISPLAYS, SENSORS, LIGHT INTERACTION AND CONTROL 审中-公开
    主动表面，包括微流体，显示器，传感器，轻微的相互作用和控制

    公开(公告)号：WO2008070048A3

    公开(公告)日：2008-08-14

    申请号：PCT/US2007024788

    申请日：2007-12-04

    Applicant: HARVARD COLLEGE ,  EDWARDS DAVID ANDREW ,  STONE HOWARD A ,  KAMLER JONATHAN JACQUES ,  MCGRATH ROBERT RENAULD ,  DI CAPUA SANDRA LIA ,  KNOPF ELIZABETH HELEN

    Inventor： EDWARDS DAVID ANDREW ,  STONE HOWARD A ,  KAMLER JONATHAN JACQUES ,  MCGRATH ROBERT RENAULD ,  DI CAPUA SANDRA LIA ,  KNOPF ELIZABETH HELEN

    IPC: G09F13/24 ,  G09F9/30

    CPC classification number: G09F13/24 ,  G09F9/30

    Abstract: The present invention generally relates to surfaces having microf luidics, displays, windows, sensors, light interaction, control, etc. One aspect of the invention is directed to a display (10) containing microf luidics (14). Another aspect of the invention is directed to systems and methods for controlling the absorbance and/or transparency of a substrate. The invention, in still another aspect, is directed to the emission of light. In yet another aspect, the invention is directed to a substrate having a controllable substantially transparent region. The invention, in still another aspect, includes the production of text and/or an image on a surface. Other aspects of the invention include surfaces able to produce energy, surfaces able to sense external stimuli, self -cleaning surfaces, and/or surfaces able to control the environment surrounding the surface. Another aspect of the invention includes embodiments having surfaces able to transfer and/or transform energy. Yet other aspects of the invention include arrays of such surfaces, kits involving such surfaces, methods for making and/or using such surfaces, methods of promoting such surfaces, or the like.

    Abstract translation: 本发明一般涉及具有微流体学，显示器，窗口，传感器，光相互作用，控制等的表面。本发明的一个方面涉及一种包含微流体（14）的显示器（10）。 本发明的另一方面涉及用于控制基材的吸光度和/或透明度的系统和方法。 在另一方面，本发明涉及光的发射。 在另一方面，本发明涉及具有可控制的基本透明区域的基底。 在另一方面，本发明包括在表面上产生文本和/或图像。 本发明的其它方面包括能够产生能量的表面，能够感测外部刺激的表面，自清洁表面和/或能够控制表面周围环境的表面。 本发明的另一方面包括具有能够传递和/或转换能量的表面的实施例。 本发明的其它方面包括这种表面的阵列，涉及这种表面的试剂盒，制造和/或使用这些表面的方法，促进这种表面的方法等。

    REACTIONS WITHIN MICROFLUIDIC CHANNELS
    6.
    发明申请
    REACTIONS WITHIN MICROFLUIDIC CHANNELS 审中-公开
    微流通道中的反应

    公开(公告)号：WO2009048533A3

    公开(公告)日：2009-10-08

    申请号：PCT/US2008011457

    申请日：2008-10-03

    Applicant: HARVARD COLLEGE ,  STONE HOWARD A ,  RISTENPART WILLIAM D ,  WAN JIANDI

    Inventor： STONE HOWARD A ,  RISTENPART WILLIAM D ,  WAN JIANDI

    IPC: B01J19/00 ,  B01L3/00

    CPC classification number: B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00957 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01L3/502776 ,  B01L2300/0867 ,  B01L2400/0487 ,  G01N1/38 ,  G01N2001/4072

    Abstract: The present invention generally relates to microfluidics and, in particular, to microfluidic systems useful for determining reactions. In one aspect, two or more fluids are introduced into a microfluidic channel, and are allowed to come into contact. At or near the interface between the fluids, reactants contained within the fluids may react. By determining the reaction rate between the reactants with respect to position within the microfluidic channel, information about the reaction between the reactants can be obtained. The reaction rate may be determined, for instance, by measuring the rate of reaction at two or more points within the channel. In some cases, e.g., if the reaction rate can be determined optically or visually, the channel may be imaged and the image analyzed to determine the reaction rate. As a non-limiting example of a reaction, the reactants may be an enzyme and a substrate, and by determining reaction rates within the channel, Michaelis-Menten kinetics (or other reaction kinetics) of the enzymatic reaction may be determined. It should be understood, however, that other reactions besides Michaelis-Menten kinetics and/or enzymatic reactions may also be determined, including other catalytic or chemical reactions, and the like. The reaction profiles may be linear or non-linear, e.g., second order, third order, etc.

    Abstract translation: 本发明一般涉及微流体，特别涉及用于确定反应的微流体系统。 在一个方面，将两种或更多种流体引入微流体通道，并允许其接触。 在液体之间或界面附近，流体中包含的反应物可能会发生反应。 通过确定反应物相对于微流体通道内的位置的反应速率，可以获得关于反应物之间的反应的信息。 反应速率可以例如通过测量通道内两个或多个点处的反应速率来确定。 在一些情况下，例如，如果反应速率可以光学上或视觉上确定，则可以对通道进行成像，并分析图像以确定反应速率。 作为反应的非限制性实例，反应物可以是酶和底物，并且通过确定通道内的反应速率，可以确定酶反应的Michaelis-Menten动力学（或其他反应动力学）。 然而，应当理解，还可以确定除Michaelis-Menten动力学和/或酶反应之外的其它反应，包括其它催化或化学反应等。 反应曲线可以是线性的或非线性的，例如二阶，三阶等

    LAMINAR MIXING APPARATUS AND METHODS
    9.
    发明申请
    LAMINAR MIXING APPARATUS AND METHODS 审中-公开
    层状混合装置和方法

    公开(公告)号：WO03011443A3

    公开(公告)日：2003-07-03

    申请号：PCT/US0223462

    申请日：2002-07-24

    Applicant: HARVARD COLLEGE ,  STROOCK ABRAHAM D ,  DERTINGER STEPHAN K W ,  AJDARI ARMAND ,  MEZIC IGOR ,  STONE HOWARD A ,  WHITESIDES GEORGE M

    Inventor： STROOCK ABRAHAM D ,  DERTINGER STEPHAN K W ,  AJDARI ARMAND ,  MEZIC IGOR ,  STONE HOWARD A ,  WHITESIDES GEORGE M

    IPC: B01F5/00 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  B81C1/00 ,  G01N27/447

    CPC classification number: B01F5/061 ,  B01F5/0646 ,  B01F13/0059 ,  B01F2005/0028 ,  B01F2005/0621 ,  B01F2005/0636 ,  B01F2215/0422 ,  B01F2215/0431 ,  B01J2219/00889 ,  Y10T137/2224 ,  Y10T436/255

    Abstract: A mixing apparatus is used to effect mixing between one or more fluid streams. The mixing apparatus generally functions by creating a transverse flow component in the fluid flowing within a channel without the use of moving mixing elements. The transverse or helical flow component of the flowing fluid or fluids can be created by weak modulations of the shape of the walls of the channel. Transverse or helical flow component can be created by grooves features defined on the channel wall. Specifically, the present invention can be used in laminarly flowing fluids. The mixing apparatus and methods thereof can effect mixing of a fluid or fluids flowing with a Reynolds number of less than about 100. Thus, the present invention can be used to mix a fluid flowing in the micro-regime. The mixing apparatus can be used to mix a fluid in a microfluidic system to significantly reduce the Taylor dispersion along the principal direction. The mixing apparatus can be used to increase the effective exposed area to promote diffusion of components between or within the fluid or fluids.

    Abstract translation: 使用混合装置来实现一个或多个流体流之间的混合。 混合装置通常通过在不使用移动的混合元件的情况下在通道内流动的流体中产生横向流动分量来起作用。 流动流体或流体的横向或螺旋流动分量可以通过通道壁的形状的弱调制而产生。 横向或螺旋流分量可以通过在通道壁上定义的凹槽特征来创建。 具体而言，本发明可用于层流流体。 该混合装置及其方法可以实现以小于约100的雷诺数流动的一种或多种流体的混合。因此，本发明可以用于混合在微观状态下流动的流体。 混合装置可以用来在微流体系统中混合流体以显着减少沿主方向的泰勒色散。 混合装置可以用来增加有效暴露面积以促进流体之间或流体内部的组分的扩散。

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