PROCESS TO COAT AN ACTIVE AGENT TO A SURFACE
    2.
    发明申请
    PROCESS TO COAT AN ACTIVE AGENT TO A SURFACE 审中-公开
    将活性剂涂在表面上的方法

    公开(公告)号:WO2013036115A1

    公开(公告)日:2013-03-14

    申请号:PCT/NL2012/050616

    申请日:2012-09-06

    CPC classification number: A61K9/0021 A61B17/205 A61M2037/0046 A61M2037/0053

    Abstract: The invention is directed to a process to prepare an object coated with an active agent by contacting an object, wherein the surface of the object has a pKa of between 4 and 7.4, with a buffered aqueous coating solution comprising a negatively charged active agent and wherein said buffered solution has a pH below the pKa, or by contacting an object, wherein the surface of the object has a pKa of between 7.4 and 10, with a buffered aqueous coating solution comprising a positively charged active agent and wherein said buffered solution has a pH above the pKa of the surface. The surface of the object may also be modified with organic molecules comprising ionisable groups which are bases and ionisable groups which are acids.

    Abstract translation: 本发明涉及一种制备用活性剂涂覆的物体的方法,该物体通过使物体的表面与pKa在4和7.4之间的接触与包含带负电荷的活性剂的缓冲水性涂布溶液接触,并且其中 所述缓冲溶液具有低于pKa的pH,或通过使物体的表面具有7.4至10的pKa与包含带正电荷的活性剂的缓冲水性涂布溶液接触,并且其中所述缓冲溶液具有 pH高于表面的pKa。 物体的表面也可以用包含可电离基团的有机分子进行改性,所述可离子基团是作为酸的碱和可离子化基团。

    AFM PROBE INTEGRATED DROPPING AND HANGING MERCURY ELECTRODE
    3.
    发明申请
    AFM PROBE INTEGRATED DROPPING AND HANGING MERCURY ELECTRODE 审中-公开
    AFM探针整体浸渍和悬挂汞电极

    公开(公告)号:WO2014124913A1

    公开(公告)日:2014-08-21

    申请号:PCT/EP2014/052585

    申请日:2014-02-11

    Abstract: The application describes apparatus and methods for performing a dropping mercury based process on a microscopic scale, using an AFM (atomic force microscopy) setup (300) with an AFM cantilever (110) comprising a micro channel (120) with a cantilever micro channel outlet f(121) or growing a mercury droplet (51), and guiding mercury through the micro channel to provide the mercury droplet at the cantilever micro channel outlet, wherein the cantilever micro channel outlet has an channel outlet hydraulic diameter selected from the range of 1 nm - 10 μm, and wherein the micro channel of the AFM cantilever has a hydraulic diameter in the range of 1 nm - 100 μm.

    Abstract translation: 该应用描述了使用具有悬臂微通道出口(110)的AFM悬臂(110)的AFM(原子力显微镜)设置(300)来执行微观尺度上的基于汞的工艺的装置和方法, f(121)或生长汞滴(51),并且引导汞通过微通道以在悬臂微通道出口处提供汞滴,其中悬臂微通道出口具有从1的范围选择的通道出口水力直径 nm-10μm,并且其中AFM悬臂的微通道的水力直径在1nm-100μm的范围内。

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