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公开(公告)号：US11412953B2
公开(公告)日：2022-08-16
申请号：US17008096
申请日：2020-08-31
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： Darryl Adamko , Anas El-Aneed
Abstract: Described are methods and uses employing metabolomic data to diagnose an asthma disease state or a Chronic Obstructive Pulmonary Disease (COPD) state. Further described are methods of uses of employing metabolomic data to distinguish between asthma and COPD. In particular, urinary metabolomic profiles are employed to enable differential diagnosis of asthma and COPD.
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公开(公告)号：US10791960B2
公开(公告)日：2020-10-06
申请号：US15579524
申请日：2016-06-03
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： Darryl Adamko , Anas El-Aneed
Abstract: Described are methods and uses employing metabolomic data to diagnose an asthma disease state or a Chronic Obstructive Pulmonary Disease (COPD) state. Further described are methods of uses of employing metabolomic data to distinguish between asthma and COPD. In particular, urinary metabolomic profiles are employed to enable differential diagnosis of asthma and COPD.
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3.发明授权Covalently functionalized nanodiamond-based MALDI matrices and methods of use thereof 有权共价功能化的基于纳米金刚石的MALDI基质及其使用方法公开(公告)号：US09012838B2
公开(公告)日：2015-04-21
申请号：US14257412
申请日：2014-04-21
Applicant: University of Saskatchewan
Inventor： Anas El-Aneed , Jackson Chitanda
IPC: B01D39/02 , B32B5/16 , B05D7/00 , C08F2/46 , C07C59/68 , C07C255/41 , C07C59/52 , H01J49/00 , A61K31/196 , A61K31/4172 , A61K47/48 , A61K48/00 , C12N15/113 , C01B31/06 , B82Y5/00
CPC classification number: C07C59/68 , A61K47/6929 , B82Y5/00 , C01B32/28 , C07B2200/11 , C07C255/41 , C07C2604/00 , H01J49/164 , Y10T428/2982 , Y10T436/143333
Abstract: The present disclosure relates to functionalized nanodiamonds comprising at least one MALDI matrix covalently bonded to a nanodiamond and compositions comprising the same. The present disclosure also relates to methods of performing matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS), for example on small molecules, using matrices comprising at least one MALDI matrix covalently bonded to a nanodiamond.
Abstract translation: 本公开内容涉及包含至少一个共价键合到纳米金刚石的MALDI基质的功能化纳米金刚石和包含其的组合物。 本公开还涉及使用包含至少一个共价键合到纳米金刚石的MALDI基质的基质进行基质辅助激光解吸/电离 - 质谱（MALDI-MS）的方法，例如在小分子上。
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4.发明申请COVALENTLY FUNCTIONALIZED NANODIAMOND-BASED MALDI MATRICES AND METHODS OF USE THEREOF 有权基于共价功能的纳米二基的MALDI矩阵及其使用方法公开(公告)号：US20140312218A1
公开(公告)日：2014-10-23
申请号：US14257412
申请日：2014-04-21
Applicant: University of Saskatchewan
Inventor： Anas El-Aneed , Jackson Chitanda
IPC: C07C59/68 , H01J49/00 , C07C229/26 , C07C255/41 , C07C59/52
CPC classification number: C07C59/68 , A61K47/6929 , B82Y5/00 , C01B32/28 , C07B2200/11 , C07C255/41 , C07C2604/00 , H01J49/164 , Y10T428/2982 , Y10T436/143333
Abstract: The present disclosure relates to functionalized nanodiamonds comprising at least one MALDI matrix covalently bonded to a nanodiamond and compositions comprising the same. The present disclosure also relates to methods of performing matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS), for example on small molecules, using matrices comprising at least one MALDI matrix covalently bonded to a nanodiamond.
Abstract translation: 本公开内容涉及包含至少一个共价键合到纳米金刚石的MALDI基质的功能化纳米金刚石和包含其的组合物。 本公开还涉及使用包含至少一个共价键合到纳米金刚石的MALDI基质的基质进行基质辅助激光解吸/电离 - 质谱（MALDI-MS）的方法，例如在小分子上。
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