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    4.
    发明专利
    未知

    公开(公告)号：DK133243B

    公开(公告)日：1976-04-12

    申请号：DK6174

    申请日：1974-01-04

    Applicant: WELLCOME FOUND

    Inventor： ROTH B

    IPC: C07D239/48

    8.
    发明专利
    未知

    公开(公告)号：DK132221B

    公开(公告)日：1975-11-10

    申请号：DK184272

    申请日：1972-04-14

    Applicant: WELLCOME FOUND

    Inventor： ROTH B

    IPC: C07D239/48 ,  C07D239/49

    Abstract: Improvements made to the subject of main patent No. 336,945 granted on October 17, 1967 for "A method of preparing 5-benzyl-pyrimidines" according to which the preparation of a 2,4-diamino-5-benzylpyrimidine of general formula **(See formula)** in which R1, R2, R4 and R5 are the same or different and each of them is a hydrogen atom, a halogen atom, an alcohol group or an alkoxy group, each containing the alkoxy and alcohol groups from 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms, and in which R3 is a saturated or unsaturated hydrocarbon radical containing up to 12 carbon atoms, which, optionally, is substituted by a halogen atom, for example chlorine, the method comprises reducing, by hydrogenolysis of the SR6 group, a compound of the formula: **(See formula)** in which R3'is R3 or a hydrogen atom and in which R6 is an alcohol group having 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms carbon, or an aralkoxy group such as benzyl and, in the event that R3'is hydrogen, react the hydroxyl group of the pyrimidine from which the thio group has been removed with a compound of formula R3Q where Q is an atom or reactive group. (Machine-translation by Google Translate, not legally binding)

    ORGANIC SYNTHETIC METHOD
    9.
    发明专利
    ORGANIC SYNTHETIC METHOD 未知

    公开(公告)号：ZA722533B

    公开(公告)日：1973-11-28

    申请号：ZA722533

    申请日：1972-04-14

    Applicant: WELLCOME FOUND

    Inventor： ROTH B

    IPC: C07D239/48 ,  C07D239/49 ,  C07D

    Abstract: Improvements made to the subject of main patent No. 336,945 granted on October 17, 1967 for "A method of preparing 5-benzyl-pyrimidines" according to which the preparation of a 2,4-diamino-5-benzylpyrimidine of general formula **(See formula)** in which R1, R2, R4 and R5 are the same or different and each of them is a hydrogen atom, a halogen atom, an alcohol group or an alkoxy group, each containing the alkoxy and alcohol groups from 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms, and in which R3 is a saturated or unsaturated hydrocarbon radical containing up to 12 carbon atoms, which, optionally, is substituted by a halogen atom, for example chlorine, the method comprises reducing, by hydrogenolysis of the SR6 group, a compound of the formula: **(See formula)** in which R3'is R3 or a hydrogen atom and in which R6 is an alcohol group having 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms carbon, or an aralkoxy group such as benzyl and, in the event that R3'is hydrogen, react the hydroxyl group of the pyrimidine from which the thio group has been removed with a compound of formula R3Q where Q is an atom or reactive group. (Machine-translation by Google Translate, not legally binding)

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