公开(公告)号：KR780000097B1

公开(公告)日：1978-04-08

申请号：KR720001836

申请日：1972-12-05

Applicant: WELLCOME FOUND

Inventor： PATERSON T ,  ROTH B ,  STUART A

IPC: C07C255/32 ,  C07C255/53 ,  C07D239/48 ,  C07D239/49

公开(公告)号：NO134837C

公开(公告)日：1976-12-21

申请号：NO391071

申请日：1971-10-21

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  STUART A ,  PATERSON T

IPC: A61K31/00 ,  A61K31/505 ,  C07D239/00 ,  C07D239/48

公开(公告)号：ZA727250B

公开(公告)日：1974-05-29

申请号：ZA727250

申请日：1972-10-11

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T

IPC: A61K31/505 ,  C07D20060101 ,  C07D239/48 ,  C07D239/49 ,  C07D

公开(公告)号：SE405119B

公开(公告)日：1978-11-20

申请号：SE1303272

申请日：1972-10-10

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T

IPC: B01J23/00 ,  B01J25/00 ,  B01J31/00 ,  C07B61/00 ,  C07D239/48 ,  C07D239/49

Abstract: 1413471 2,4-Diamino-5-benzyl pyrimidines WELLCOME FOUNDATION Ltd 12 Oct 1972 [12 Oct 1971 10 Dec 1971] 47492/71 and 57512/71 Heading C2C Compounds having the general formula wherein one of Q 1 and Q 2 is a 2,4-diaminopyrimidin.5-yl methyl group, R 1 , R 2 , R 3 and the other Q group are hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, and R 6 is hydrogen or alkyl, provided that when Q 2 is the pyrimidyl group Q 1 is not hydrogen; may be prepared by reacting a compound of formula wherein R 71 is hydroxyl, halogen, or the anionic residue of a carboxylic or sulphonic acid, with a compound of the formula wherein at least one of R 4 and R 5 is hydrogen and the other is hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, in a polar non-phenolic solvent capable of dissolving both reactants, and, when R 6 is alkyl, alkylating the product with an alkylating agent R 6 Z wherein Z is a reactive atom or group. The invention further comprises compounds having the general formula wherein whenever Q 1 is 2,4-diaminopyrimidin- 5-yl-methyl and whenever at least one of R 3 and Q 2 is alkyl or alkoxy, then at least one of R 1 and R 2 is other than hydrogen.

公开(公告)号：SE7506083A

公开(公告)日：1975-05-28

申请号：SE7506083

申请日：1975-05-28

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T

IPC: B01J23/00 ,  B01J25/00 ,  B01J31/00 ,  C07B61/00 ,  C07D239/48 ,  C07D239/49

CPC classification number: C07D239/48 ,  C07D239/49

公开(公告)号：ZA7107047B

公开(公告)日：1973-06-27

申请号：ZA7107047

申请日：1971-10-21

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T ,  ROTH B

IPC: A61K20060101 ,  C07D20060101 ,  C07D239/49 ,  C07D ,  A61K

CPC classification number: Y10S514/895

公开(公告)号：ZA714379B

公开(公告)日：1973-02-28

申请号：ZA714379

申请日：1971-07-05

Applicant: WELLCOME FOUND

Inventor： CURRAN A ,  AL HASSAN S ,  WOOD H ,  STUART A

IPC: C07C29/147 ,  C07C205/15 ,  C07C207/00 ,  C07C207/04 ,  C07D239/46 ,  C07D239/48 ,  C07D475/04 ,  A61K ,  C07D

公开(公告)号：ZA7104379B

公开(公告)日：1973-02-28

申请号：ZA7104379

申请日：1971-07-05

Applicant: WELLCOME FOUND

Inventor： CURRAN A ,  AL HASSAN S ,  WOOD H ,  STUART A

IPC: C07C29/147 ,  C07C205/15 ,  C07C207/00 ,  C07C207/04 ,  C07D239/46 ,  C07D239/48 ,  C07D475/04 ,  A61K ,  C07D

CPC classification number: C07D239/47 ,  C07C29/147 ,  C07C67/00 ,  C07C67/08 ,  C07C201/00 ,  C07C201/12 ,  C07D239/48 ,  C07D475/04 ,  C07C33/18 ,  C07C205/15 ,  C07C207/04 ,  C07C69/145

公开(公告)号：DK132795C

公开(公告)日：1976-07-12

申请号：DK501972

申请日：1972-10-11

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T

IPC: B01J23/00 ,  B01J25/00 ,  B01J31/00 ,  C07B61/00 ,  C07D239/48 ,  C07D239/49

Abstract: 1413471 2,4-Diamino-5-benzyl pyrimidines WELLCOME FOUNDATION Ltd 12 Oct 1972 [12 Oct 1971 10 Dec 1971] 47492/71 and 57512/71 Heading C2C Compounds having the general formula wherein one of Q 1 and Q 2 is a 2,4-diaminopyrimidin.5-yl methyl group, R 1 , R 2 , R 3 and the other Q group are hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, and R 6 is hydrogen or alkyl, provided that when Q 2 is the pyrimidyl group Q 1 is not hydrogen; may be prepared by reacting a compound of formula wherein R 71 is hydroxyl, halogen, or the anionic residue of a carboxylic or sulphonic acid, with a compound of the formula wherein at least one of R 4 and R 5 is hydrogen and the other is hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, in a polar non-phenolic solvent capable of dissolving both reactants, and, when R 6 is alkyl, alkylating the product with an alkylating agent R 6 Z wherein Z is a reactive atom or group. The invention further comprises compounds having the general formula wherein whenever Q 1 is 2,4-diaminopyrimidin- 5-yl-methyl and whenever at least one of R 3 and Q 2 is alkyl or alkoxy, then at least one of R 1 and R 2 is other than hydrogen.

公开(公告)号：DK132795B

公开(公告)日：1976-02-09

申请号：DK501972

申请日：1972-10-11

Applicant: WELLCOME FOUND

Inventor： STUART A ,  PATERSON T

IPC: B01J23/00 ,  B01J25/00 ,  B01J31/00 ,  C07B61/00 ,  C07D239/48 ,  C07D239/49

Abstract: 1413471 2,4-Diamino-5-benzyl pyrimidines WELLCOME FOUNDATION Ltd 12 Oct 1972 [12 Oct 1971 10 Dec 1971] 47492/71 and 57512/71 Heading C2C Compounds having the general formula wherein one of Q 1 and Q 2 is a 2,4-diaminopyrimidin.5-yl methyl group, R 1 , R 2 , R 3 and the other Q group are hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, and R 6 is hydrogen or alkyl, provided that when Q 2 is the pyrimidyl group Q 1 is not hydrogen; may be prepared by reacting a compound of formula wherein R 71 is hydroxyl, halogen, or the anionic residue of a carboxylic or sulphonic acid, with a compound of the formula wherein at least one of R 4 and R 5 is hydrogen and the other is hydrogen, halogen or C 1 to C 4 alkyl or alkoxy, in a polar non-phenolic solvent capable of dissolving both reactants, and, when R 6 is alkyl, alkylating the product with an alkylating agent R 6 Z wherein Z is a reactive atom or group. The invention further comprises compounds having the general formula wherein whenever Q 1 is 2,4-diaminopyrimidin- 5-yl-methyl and whenever at least one of R 3 and Q 2 is alkyl or alkoxy, then at least one of R 1 and R 2 is other than hydrogen.