公开(公告)号：WO2015134999A2

公开(公告)日：2015-09-11

申请号：PCT/US2015/019541

申请日：2015-03-09

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  WORCESTER POLYTECHNIC INSTITUTE

Inventor： ALSBERG, Eben ,  DIKINA, Anna D. ,  ROLLE, Marsha W.

IPC: C12N15/85

CPC classification number: C12N5/0654 ,  A61K35/32 ,  C12N5/0655 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2513/00 ,  C12N2531/00 ,  C12N2533/18 ,  C12N2533/54 ,  C12N2533/76

Abstract: A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate.

Abstract translation: 模块化工程组织结构包括多个融合的自组装，无支架的高密度细胞聚集体。 至少一个细胞聚集体包括多个细胞和多个生物相容性和可生物降解的纳米颗粒和/或微粒，其被并入细胞聚集体内。 用作细胞聚集体内的填充剂的纳米颗粒和/或微粒以增加细胞聚集体的尺寸和/或厚度并改善细胞聚集体的机械性能。

公开(公告)号：WO2019204729A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/028324

申请日：2019-04-19

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： LOZEAU, Lindsay D. ,  HANSON, Abigail ,  MACE, Joshua B. ,  METTERS, Frederick T. ,  SHERLOCK, Nicole ,  CAMESANO, Terri A. ,  ROLLE, Marsha W.

IPC: A61K9/00 ,  A61Q17/00 ,  C07K14/47 ,  C07K14/78

Abstract: Aspects of the disclosure relate to a topical composition comprising (1) at least one fusion peptide comprising at least one antimicrobial peptide and at least one peptide capable of improving the stability, the activity or the stability and the activity of the antimicrobial peptide in a hydrophobic environment, (2) at least one essential oil, wherein the composition comprises the at least one fusion peptide and the at least one essential oil at concentrations capable of providing synergistic anti-inflammatory activity and/or antimicrobial activity.

公开(公告)号：EP3114212B1

公开(公告)日：2020-07-08

申请号：EP15758207.3

申请日：2015-03-09

Applicant: Case Western Reserve University ,  Worcester Polytechnic Institute

Inventor： ALSBERG, Eben ,  DIKINA, Anna D. ,  ROLLE, Marsha W.

IPC: A61F2/20 ,  A61K35/32 ,  C12N5/00 ,  C12N5/02 ,  C12N5/077

公开(公告)号：EP3114212A2

公开(公告)日：2017-01-11

申请号：EP15758207.3

申请日：2015-03-09

Applicant: Case Western Reserve University ,  Worcester Polytechnic Institute

Inventor： ALSBERG, Eben ,  DIKINA, Anna D. ,  ROLLE, Marsha W.

IPC: C12N5/00 ,  C12N5/02 ,  A61F2/20

Abstract: A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate.

Abstract translation: 模块化工程组织结构包括多个融合的自组装，无支架的高密度细胞聚集体。 至少一个细胞聚集体包括多个细胞和多个生物相容性和可生物降解的纳米颗粒和/或微粒，其被并入细胞聚集体内。 用作细胞聚集体内的填充剂的纳米颗粒和/或微粒以增加细胞聚集体尺寸和/或厚度并改善细胞聚集体的机械性能。