公开(公告)号：WO2021203041A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/025637

申请日：2021-04-02

Applicant: WAYNE STATE UNIVERSITY

Inventor： AUNER, Gregory William ,  BRUSATORI, Michelle Ann ,  SHANLEY, Charles James ,  KOYA, Satya Kiran

IPC: G01N21/65 ,  C12Q1/18 ,  G01J2003/1861 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/1838 ,  G01J3/44 ,  G01N2021/651 ,  G01N2333/11 ,  G01N2333/165 ,  G01N33/56983

Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a Raman spectroscopic system for determining antimicrobial resistance of a pathogen in a sample is provided. The Raman spectroscopic system may include a cuvette configured to receive the sample, an excitation light source configured to radiate a light beam into the cuvette through a bottom end of the cuvette and onto a portion of the sample contained in the cuvette, and at least one optical element configured to direct a Raman signal from the portion of the sample passing through the bottom end of the cuvette to a Raman spectrometer. The Raman spectroscopic system is configured to detect resistance or susceptibility of the pathogen to at least one antimicrobial agent based on the Raman signal.