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    METHOD AND SYSTEM FOR JOINT DEMOSAICKING AND SPECTRAL SIGNATURE ESTIMATION
    1.
    发明申请
    METHOD AND SYSTEM FOR JOINT DEMOSAICKING AND SPECTRAL SIGNATURE ESTIMATION 审中-公开

    公开(公告)号：WO2021245374A1

    公开(公告)日：2021-12-09

    申请号：PCT/GB2021/051280

    申请日：2021-05-26

    Applicant: KING'S COLLEGE LONDON

    Inventor： VERCAUTEREN, Tom ,  EBNER, Michael ,  XIE, Yijing ,  NABAVI, Eli

    IPC: G01J3/28 ,  G01J3/02 ,  A61B1/00 ,  A61B5/00 ,  G06T5/00 ,  G01J3/12 ,  H04N9/04 ,  A61B1/00009 ,  A61B5/0075 ,  G01J2003/1217 ,  G01J2003/283 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/2823 ,  H04N5/332 ,  H04N9/04515 ,  H04N9/04559

    Abstract: Embodiments of the invention provide a method and system that allows parameters of a desired target image to be determined from hyperspectral imagery of scene. The parameters may be representative of various aspects of the scene being imaged, particularly representative of physical properties of the scene. For example, in some medical imaging contexts, the property being imaged may be blood perfusion or oxygenation saturation level information per pixel. In one embodiment the parameters are obtained by collecting lower temporal and spatial resolution hyperspectral imagery, and then building a virtual hypercube of the information having a higher spatial resolution using a spatiospectral aware demosaicking process, the virtual hypercube then being used for estimation of the desired parameters at the higher spatial resolution. Alternatively, in another embodiment, instead of building the virtual hypercube and then performing the estimation, a joint demosaicking and parameter estimation operation is performed to obtain the parameters. Various white level and spectral calibration operations may also be performed to improve the results obtained. While establishing functional and technical requirements of an intraoperative system for surgery, we present iHSI system embodiments that allows for real-time wide-field HSI and responsive surgical guidance in a highly constrained operating theatre. Two exemplar embodiments exploiting state-of-the-art industrial HSI cameras, respectively using linescan and snapshot imaging technology, were investigated by performing assessments against established design criteria and ex vivo tissue experiments. We further report the use of one real-time iHSI embodiment during an ethically-approved in-patient clinical feasibility case study as part of a spinal fusion surgery therefore successfully validating our assumptions that our invention can be seamlessly integrated into the operating theatre without interrupting the surgical workflow.

    METHOD AND APPARATUS FOR THE MOLECULAR ATOMIC ANALYSIS OF A FLUID IN THE GASEOUS STATE
    2.
    发明申请
    METHOD AND APPARATUS FOR THE MOLECULAR ATOMIC ANALYSIS OF A FLUID IN THE GASEOUS STATE 审中-公开

    公开(公告)号：WO2021198979A1

    公开(公告)日：2021-10-07

    申请号：PCT/IB2021/052748

    申请日：2021-04-01

    Applicant: ISTITUTO NAZIONALE DI FISICA NUCLEARE

    Inventor： CARUGNO, Giovanni

    IPC: G01N21/71 ,  G01J3/443 ,  H01J49/00 ,  G01J3/0218 ,  G01J3/18 ,  G01N21/718 ,  H01J49/162 ,  H01J49/40

    Abstract: The present invention relates to a method and an apparatus for the molecular atomic analysis of a fluid in the gaseous state wherein, in particular, the method comprises introducing (901) a fluid in the gaseous state into a collection chamber (12) having a predetermined internal volume V and generating (902) a laser beam through a laser device (11). The method further comprises focusing (903) such beam onto the fluid sited in the collection chamber (12), in order to create an electric field in at least a portion V' of the internal volume V, such as to excite the electrons residing on the atoms and molecules present in said fluid in the gaseous state, whose binding energy is between about 1 eV and about 10 eV, causing an atomic /molecular alteration of the fluid itself in said portion V'. The method provides detecting (904) the elements emitted after focusing the beam on said fluid, through detection means (17, 18) and analysing (905) the elements detected by the detection means (17, 18) using a processing unit (20). According to the method of the invention, the generation of a laser beam comprises varying (906) at least once the frequency of the beam emitted. According to the method, the processing unit (20) is configured to operate said variation (906) of the frequency of the laser beam emitted by the laser device (11), based on the pressure conditions of the fluid sited in the collection chamber (12).

    STIMULATED RAMAN SPECTROSCOPY FOR REAL-TIME, HIGH-RESOLUTION MOLECULAR ANALYSIS OF GASES IN HOLLOW CORE FIBRES
    8.
    发明申请
    STIMULATED RAMAN SPECTROSCOPY FOR REAL-TIME, HIGH-RESOLUTION MOLECULAR ANALYSIS OF GASES IN HOLLOW CORE FIBRES 审中-公开

    公开(公告)号：WO2021117041A1

    公开(公告)日：2021-06-17

    申请号：PCT/IL2020/051273

    申请日：2020-12-09

    Applicant: OPTIQGAIN LTD.

    Inventor： ALON, Ram ,  WOLF, Israel

    IPC: G01N21/65 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/44 ,  G01N2021/651 ,  G01N2021/655 ,  G01N2201/088 ,  G02B6/02328

    Abstract: A stimulated Raman scattering spectrometer for real-time, high- resolution molecular analysis of gases is based on two hollow-core fibres (420, 450) illuminated by a single high-power, short-pulse laser pump. The first fibre (420) is prefilled with high-concentration target gases. Interaction of each target gas inside the first fibre (420), with the laser pump, generates Raman signals corresponding to the target gases. The combined beam of the Raman signals and the pump laser beam is directed into the second fibre (450) containing the measured target gases. Interaction of each target gas with the combined beam generates the Stimulated Raman Growth, i.e., amplification of the Raman signal, which is proportional to the corresponding target gas concentration. A receiver subsystem (30) receives the beam from the second fibre (450), spectrally separates it to wavelengths corresponding to each target gas, extracts the Stimulated Raman Growth value corresponding to each target gas and calculates the concentration of each target gas.

    OPTICAL SYSTEM AND METHODS OF USE
    9.
    发明申请
    OPTICAL SYSTEM AND METHODS OF USE 审中-公开

    公开(公告)号：WO2023274880A1

    公开(公告)日：2023-01-05

    申请号：PCT/EP2022/067374

    申请日：2022-06-24

    Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBH

    Inventor： NIEMEYER, Axel ,  GRIESSNER, Matthias ,  OSÓRIO, Ricardo

    IPC: G01N21/25 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35 ,  G01N21/359 ,  G01J3/0218 ,  G01J3/28 ,  G01J3/44 ,  G01J3/4406 ,  G01N2021/3155 ,  G01N21/255 ,  G01N2201/0624 ,  G01N2201/0627 ,  G01N2201/08 ,  G01N33/487

    Abstract: The present invention relates to an optical system having a chamber (26) for receiving an element (E) of body fluid or tissue or environmental sample to be characterized by the optical system, a light source (5) for illuminating the chamber (26) with light, and a spectrometer (6) for recording a spectrum of light originating from the chamber (26), wherein the light source (5) comprising two separate LEDs (5A, 5B) to emit light having at least two spectral maxima of different wavelength ranges, and the light source (5) is coupled to the chamber (26) such that the light is directed from the light source (5) to the chamber (26) when the light source (5) is activated. Further, the present invention relates to a method for determining a parameter with an optical system, wherein the optical system comprises a chamber (26) for receiving an element of body fluid or tissue or environmental sample to be characterized by the optical system, a light source (5) for illuminating the chamber with light, and a spectrometer (6) for measuring a spectrum of light originating from the chamber (26), wherein, in order to determine a parameter representing a property of the element, light having at least two spectral maxima of different wavelength ranges are generated by separate LEDs (5A, 5B) and is directed onto the element, a spectrum comprising reflected components of the light, scattered components of the light, and/or light caused by raman scattering or fluorescence of the element is measured with the spectrometer (6), and the parameter is determined by evaluating the spectrum.

    MULTIPURPOSE SPECTROSCOPIC, HYPERSPECTRAL AND DIGITAL IMAGING DEVICE
    10.
    发明申请
    MULTIPURPOSE SPECTROSCOPIC, HYPERSPECTRAL AND DIGITAL IMAGING DEVICE 审中-公开

    公开(公告)号：WO2021250537A1

    公开(公告)日：2021-12-16

    申请号：PCT/IB2021/054963

    申请日：2021-06-07

    Applicant: TÜBİTAK

    Inventor： KILIÇ, Cihan ,  GÜLMEZ, Yakup ,  ÖZKAN, Turgay ,  TAKAOĞLU, Faruk ,  ATAY, Merve ,  KAYILLIOĞLU, Oğuz ,  ATAY, Bilal ,  DALKILIÇ, Emre ,  ÇETİN, Yücel ,  ARDIÇ, Emre

    IPC: G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0248

    Abstract: The invention can use different types of illumination sources to obtain radiation in the 250-1100nm wavelength range that includes a part of the visible, ultraviolet and infrared region of the electromagnetic spectrum, without the need for any external intervention, as a result of the moving illumination panels, the open frame stage, and the moving imaging system, It is related to a spectroscopic, hyperspectral and digital imaging device that provides the measurement of the energy of the light reflected from the surface of the object at different wavelengths by being homogeneously and strongly illuminated from all possible aspect and directions of the object subject to examination. The device in question basically includes; a movable floor table on which the object to be examined is placed and can be easily disassembled and installed thanks to the socketed structure of the vacuum module, which functions to fix the object to the floor and smooth its surface depending on the need, movable illumination panels that enable the use of different types of illumination sources for different wavelengths in the desired combination and number, and to adjust the angle of incidence of the light to the object to be examined at the time of examination with its mobility in horizontal and vertical axis; spectroscopic measurement module which contains the spectrometer optical fiber tips arranged in the probe tip are brought closer to the object surface to a distance of 1 mm to the surface of the object to be examined and positioned accurately to the target point to be measured by endoscopic cameras, thus enabling measurement with high accuracy and precision, free from interference effects and noise-free; colorful and monochrome camera modules, a lens system with high optical zooming capacity, a linear optical filter and a moving imaging system with motion mechanisms that ensure their alignment with each other. Spectral information of each pixel in images obtained using many narrow wavelength bands is processed using hyperspectral image analysis methods, pattern recognition algorithms, machine learning, and deep learning algorithms in a computer to which the device is connected, and extracting the desired information from the images, identifying and classifying the object and anomaly (contradiction) can be detected.

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