公开(公告)号：WO2005119325A2

公开(公告)日：2005-12-15

申请号：PCT/US2005/018677

申请日：2005-05-26

Applicant: APERIO TECHNOLOGIES, INC. ,  OLSON, Allen ,  SALIGRAMAL, Kiran ,  SOENKSEN, Dirk, G.

Inventor： OLSON, Allen ,  SALIGRAMAL, Kiran ,  SOENKSEN, Dirk, G.

IPC: G02B7/04

CPC classification number: G06T7/0012 ,  G02B21/365 ,  G06K9/00127 ,  G06K9/036 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/30024

Abstract: Systems and methods for assessing virtual microscope slide image quality are provided. In order to determine whether a virtual slide image has any out of focus areas and is therefore a candidate for manual inspection, the various focus points used to scan the virtual slide image are used to calculate a best fit surface for the virtual slide image. The distance of each focus point from the best fit surface is then calculated and the largest distance is compared to a predetermined value. If the largest distance from a focus point to the best fit surface is larger than the predetermined value, then the virtual slide image is designated as needing a manual inspection and possible re-scan.

Abstract translation: 提供了评估虚拟显微镜幻灯片图像质量的系统和方法。 为了确定虚拟幻灯片图像是否具有任何偏离焦点区域，因此是用于手动检查的候选者，用于扫描虚拟幻灯片图像的各种对焦点用于计算虚拟幻灯片图像的最佳拟合曲面。 然后计算每个对焦点与最佳拟合表面的距离，并将最大距离与预定值进行比较。 如果从焦点到最佳配合曲面的最大距离大于预定值，则虚拟幻灯片图像被指定为需要手动检查和可能的重新扫描。

公开(公告)号：WO2004079523A2

公开(公告)日：2004-09-16

申请号：PCT/US2004/006013

申请日：2004-02-27

Applicant: APERIO TECHNOLOGIES, INC. ,  EICHHORN, Ole ,  OLSON, Allen

Inventor： EICHHORN, Ole ,  OLSON, Allen

IPC: G06F

CPC classification number: G06T7/0012 ,  G06F19/00 ,  G06F19/321 ,  G06T1/00 ,  G06T2207/10056 ,  G06T2207/20016

Abstract: A system and method for processing and analyzing virtual microscopy digital images ("virtual slides") is provided. The system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of virtual slides. The algorithm server executes a selected routine on an identified virtual slide and provides the resulting data. The virtual slide can be accessed locally or remotely across a network. Similarly, the image processing routines can be obtained from local storage or across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely obtained routines. Access to image processing and analysis may be restricted through a monitor process that authenticates requests to process or view virtual slides. Variations in restrictions to images provide a rich diversity in access levels that allow sharing of virtual slides and demonstrations of image processing algorithms.

Abstract translation: 提供了一种用于处理和分析虚拟显微镜数字图像（“虚拟幻灯片”）的系统和方法。 该系统包括维护或访问多个图像处理和分析例程的算法服务器。 算法服务器还可以访问多个虚拟幻灯片。 算法服务器在识别的虚拟幻灯片上执行所选择的例程，并提供所得到的数据。 虚拟幻灯片可以通过网络在本地或远程访问。 类似地，图像处理例程可以从本地存储器或网络或两者获得。 有利地，某些公共子例程可以被本地存储以包含在其他本地或远程获得的例程中。 图像处理和分析的访问可能会通过对进程或查看虚拟幻灯片的请求进行身份验证的监视进程来限制。 对图像限制的变化提供了访问级别丰富的多样性，允许共享虚拟幻灯片和图像处理算法的演示。

公开(公告)号：WO2014051696A1

公开(公告)日：2014-04-03

申请号：PCT/US2013/032583

申请日：2013-03-15

Applicant: APERIO TECHNOLOGIES, INC.

Inventor： SOENKSEN, Dirk ,  WRENN, Mark ,  VOLYNSKAYA, Zoya

IPC: G06Q50/22 ,  G06T7/00

CPC classification number: G06F19/321 ,  G06F19/00 ,  G06Q10/101 ,  G06Q50/22 ,  G16H80/00

Abstract: Medical image based collaboration system and methods are provided. A collaboration server 40 creates a medical image based case in response to a request from a requesting system 10 and populates the case with the minimum required information comprising at least a digital medical image and a case number. The collaboration server 40 provides the medical image based case to a consulting system 30 and receives analysis information in response. The collaboration server 40 stores the analysis information in association with the medical image based case and provides the analysis information to the consulting system 30 to complete the medical image based collaboration.

Abstract translation: 提供了基于医学图像的协作系统和方法。 协作服务器40响应于来自请求系统10的请求创建基于医学图像的情况，并且使用包括至少数字医学图像和病例号的最小必需信息来填充病例。 协作服务器40将医学图像的情况提供给咨询系统30，并且响应地接收分析信息。 协作服务器40与基于医学图像的情况相关联地存储分析信息，并将分析信息提供给咨询系统30，以完成基于医学图像的协作。

公开(公告)号：WO2013010023A3

公开(公告)日：2013-03-07

申请号：PCT/US2012046535

申请日：2012-07-12

Applicant: APERIO TECHNOLOGIES INC ,  CRANDALL GREGORY ,  OLSON ALLEN

Inventor： CRANDALL GREGORY ,  OLSON ALLEN

IPC: G06T7/00 ,  G01N21/64

CPC classification number: G01N21/64 ,  G01J3/0235 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/4406 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6471 ,  G02B21/365 ,  G06T5/009 ,  G06T5/40 ,  G06T7/74 ,  G06T7/80 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/10064

Abstract: Systems and methods for standardizing one or more fluorescence scanning instruments to a reference system by separating the effects of drift and normalization. In an embodiment, a drift image comprising an image of a drift reference slide is captured by a system to be standardized. A drift measurement is calculated using the drift image. A first normalization image comprising an image of a normalization slide is also captured by the system to be standardized. A reference normalization image, also comprising an image of the normalization slide, is captured by a reference system. The first normalization image is compared to the reference normalization image to determine a gamma value and offset value for the system to be standardized.

Abstract translation: 通过分离漂移和归一化的影响，将一个或多个荧光扫描仪器标准化为参考系统的系统和方法。 在一个实施例中，包括漂移参考载玻片的图像的漂移图像被系统捕获以被标准化。 使用漂移图像计算漂移测量值。 包括归一化幻灯片的图像的第一归一化图像也被系统捕获以被标准化。 参考标准化图像，也包括标准化幻灯片的图像，由参考系统捕获。 将第一归一化图像与参考归一化图像进行比较以确定要标准化的系统的伽玛值和偏移值。

公开(公告)号：WO2013010023A2

公开(公告)日：2013-01-17

申请号：PCT/US2012/046535

申请日：2012-07-12

Applicant: APERIO TECHNOLOGIES, INC. ,  CRANDALL, Gregory ,  OLSON, Allen

Inventor： CRANDALL, Gregory ,  OLSON, Allen

IPC: G06T7/00 ,  G01N21/64

CPC classification number: G01N21/64 ,  G01J3/0235 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/4406 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6471 ,  G02B21/365 ,  G06T5/009 ,  G06T5/40 ,  G06T7/74 ,  G06T7/80 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/10064

Abstract: Systems and methods for standardizing one or more fluorescence scanning instruments to a reference system by separating the effects of drift and normalization. In an embodiment, a drift image comprising an image of a drift reference slide is captured by a system to be standardized. A drift measurement is calculated using the drift image. A first normalization image comprising an image of a normalization slide is also captured by the system to be standardized. A reference normalization image, also comprising an image of the normalization slide, is captured by a reference system. The first normalization image is compared to the reference normalization image to determine a gamma value and offset value for the system to be standardized.

Abstract translation: 通过分离漂移和归一化的影响将一个或多个荧光扫描仪器标准化到参考系统的系统和方法。 在一个实施例中，包括漂移参考幻灯片的图像的漂移图像由待标准化的系统捕获。 使用漂移图像计算漂移测量。 包括标准化幻灯片的图像的第一归一化图像也被要标准化的系统捕获。 还包括归一化幻灯片的图像的参考归一化图像由参考系统捕获。 将第一归一化图像与参考归一化图像进行比较，以确定要标准化的系统的伽马值和偏移值。

公开(公告)号：WO2010048584A3

公开(公告)日：2010-04-29

申请号：PCT/US2009/061957

申请日：2009-10-23

Applicant: APERIO TECHNOLOGIES, INC. ,  NAJMABADI, Peyman ,  CRANDALL, Gregory J. ,  STEARRETT, Aaron Alan ,  SOENKSEN, Dirk G. ,  LEE, Christopher Adam ,  PERZ, Cynthia

Inventor： NAJMABADI, Peyman ,  CRANDALL, Gregory J. ,  STEARRETT, Aaron Alan ,  SOENKSEN, Dirk G. ,  LEE, Christopher Adam ,  PERZ, Cynthia

IPC: G01N21/64 ,  G01N21/85 ,  G01B11/00 ,  G01N35/00

Abstract: A whole slide fluorescence digital pathology system is provided that uses a monochrome TDI line scan camera, which is particularly useful in fluorescence scanning where the signal is typically much weaker than in brightfield microscopy. The system uses oblique brightfield illumination for fast and accurate tissue finding and employs a unique double sweep focus scoring and objective lens height averaging technique to identify focus points and create a focus map that can be followed during subsequent scanning to provide autofocusing capability. The system also scans and analyzes image data to determine the optimal line rate for the TDI line scan camera to use during subsequent scanning of the digital slide image and it also creates a light profile to compensate for loss of illumination light due to roll off.

公开(公告)号：WO2008005861A2

公开(公告)日：2008-01-10

申请号：PCT/US2007072527

申请日：2007-06-29

Applicant: APERIO TECHNOLOGIES INC ,  EICHHORN OLE

Inventor： EICHHORN OLE

IPC: G03B17/50

CPC classification number: G06F17/30277 ,  G06F17/30106 ,  G06F17/3028 ,  Y10S707/915 ,  Y10S707/966

Abstract: Images created by one or more image acquisition devices are initially stored in remote data bases at one or more remote or satellite locations and copies of the images are subsequently transferred to a central server at a central storage location over a network and stored in a central data base. A common catalog listing local image files stored at the central data base and remote image files stored at one or more remote data bases is stored at the central location and is accessed by users to search for images. User requests for images associated with local image files result in transfer of the requested images by the central server to the user. User requests for images associated with remote image files are relayed by the central server to the associated remote location, and the requested images are then relayed to the user from the remote location via the central server.

Abstract translation: 由一个或多个图像采集设备创建的图像最初存储在远程数据库中的一个或多个远程或卫星位置，并且图像的副本随后通过网络传输到中央存储位置处的中央服务器并存储在中央数据 基础。 存储在中央数据库中的本地图像文件和存储在一个或多个远程数据库中的远程图像文件的通用目录存储在中央位置，并且由用户访问以搜索图像。 用户对与本地图像文件相关联的图像的请求导致中央服务器向用户传送所请求的图像。 与远程图像文件相关联的图像的用户请求被中央服务器中继到关联的远程位置，然后所请求的图像经由中央服务器从远程位置中继到用户。

公开(公告)号：WO2005119575A2

公开(公告)日：2005-12-15

申请号：PCT/US2005/018553

申请日：2005-05-27

Applicant: APERIO TECHNOLOGIES, INC ,  EICHHORN, Ole ,  CRANDALL, Greg J. ,  HASHAGEN, Steven ,  SOENKSEN, Dirk G. ,  WRENN, Mark

Inventor： EICHHORN, Ole ,  CRANDALL, Greg J. ,  HASHAGEN, Steven ,  SOENKSEN, Dirk G. ,  WRENN, Mark

IPC: G06K9/00

CPC classification number: G02B27/2278 ,  G02B21/367 ,  G06K9/00201 ,  H04N13/395

Abstract: Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.

Abstract translation: 提供了用于创建和查看三维虚拟幻灯片的系统和方法。 将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。 该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。 图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。 然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

公开(公告)号：WO2004077338A3

公开(公告)日：2005-06-09

申请号：PCT/US2004006012

申请日：2004-02-27

Applicant: APERIO TECHNOLOGIES INC ,  EICHHORN OLE ,  BRUMME ANNE

Inventor： EICHHORN OLE ,  BRUMME ANNE

IPC: G02B21/26 ,  G02B21/32 ,  G06F17/30 ,  G06K20060101 ,  G06K9/00

CPC classification number: H04L65/403 ,  G02B21/26 ,  G02B21/32 ,  G06F3/1454 ,  G06F17/241 ,  G06F17/30905 ,  G06F19/321 ,  G06Q50/24

Abstract: Virtual slide image data and corresponding information are stored in a data storage area on a virtual slide image server. A client viewer requests image data at a particular resolution. The image server obtains corresponding image data from the data storage area at a resolution nearest to the requested resolution. The image data is then sent to the client viewer. The client viewer receives the image data and scales the image data to the requested resolution prior to displaying the image data.

Abstract translation: 虚拟幻灯片图像数据和相应的信息存储在虚拟幻灯片服务器上的数据存储区域中。 客户端查看器以特定分辨率请求图像数据。 图像服务器以最接近请求的分辨率的分辨率从数据存储区域获取相应的图像数据。 然后将图像数据发送到客户端查看器。 在显示图像数据之前，客户端查看器接收图像数据并将图像数据缩放到所请求的分辨率。

公开(公告)号：WO2004077338A2

公开(公告)日：2004-09-10

申请号：PCT/US2004/006012

申请日：2004-02-27

Applicant: APERIO TECHNOLOGIES, INC. ,  EICHHORN, Ole ,  BRUMME, Anne

Inventor： EICHHORN, Ole ,  BRUMME, Anne

IPC: G06K

CPC classification number: H04L65/403 ,  G02B21/26 ,  G02B21/32 ,  G06F3/1454 ,  G06F17/241 ,  G06F17/30905 ,  G06F19/00 ,  G06F19/321 ,  G06Q50/24

Abstract: Virtual slide image data and corresponding information are stored in a data storage area on a virtual slide image server. A client viewer requests image data at a particular resolution. The image server obtains corresponding image data from the data storage area at a resolution nearest to the requested resolution. The image data is then sent to the client viewer. The client viewer receives the image data and scales the image data to the requested resolution prior to displaying the image data.

Abstract translation: 虚拟幻灯片图像数据和相应的信息存储在虚拟幻灯片服务器上的数据存储区域中。 客户端查看器以特定分辨率请求图像数据。 图像服务器以最接近请求的分辨率的分辨率从数据存储区域获取相应的图像数据。 然后将图像数据发送到客户端查看器。 在显示图像数据之前，客户端查看器接收图像数据并将图像数据缩放到所请求的分辨率。