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公开(公告)号：GB201617564D0
公开(公告)日：2016-11-30
申请号：GB201617564
申请日：2016-10-17
Applicant: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH AND NATIONAL UNIVERSITY OF SINGAPORE AND SINGAPORE HEALTH
Abstract: The invention relates to methods for producing an antibody which is specific for a mutant p53 polypeptide over wildtype p53 polypeptide, comprising using said mutant p53 polypeptide as an immunogen wherein said polypeptide comprises: (i) an antigen sequence, comprising an amino acid sequence of the mutant p53 polypeptide including the mutation and at least one amino acid immediately adjacent to the mutation, and (ii) a scaffold sequence for providing the antigen sequence in a solvent-accessible configuration, in particular wherein the scaffold sequence is thioredoxin. In the specific embodiments, antibodies against mutant p53 comprising R175H, R248Q or R273H are generated. Also disclosed are the uses of said antibodies for diagnosis, prognosis and stratification of patient groups and further encompasses the use of antibodies for imaging and treatment of cancer.
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公开(公告)号：AU2008355778B2
公开(公告)日：2015-02-12
申请号：AU2008355778
申请日：2008-04-28
Inventor： GUAN CUNTAI , PHUA KOK SOON , WANG CHUANCHU , HAMADI CHAREF BRAHIM AHMED SALAH , ZHANG HAIHONG
Abstract: A method and system for concentration detection. The method for concentration detection comprises the steps of extracting temporal features from brain signals; classifying the extracted temporal features using a classifier to give a score x
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公开(公告)号：AU2009215934C1
公开(公告)日：2014-05-08
申请号：AU2009215934
申请日：2009-02-21
Inventor： LIM SAI KIANG
IPC: A61K35/12 , A61K35/28 , C12N5/0775
Abstract: We describe a particle secreted by a mesenchymal stem cell and comprising at least one biological property of a mesenchymal stem cell. The biological property may comprise a biological activity of a mesenchymal stem cell conditioned medium (MSC- CM) such as cardioprotection or reduction of infarct size. The particle may comprise a vesicle or an exosome.
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公开(公告)号：AU2018200152B2
公开(公告)日：2019-05-02
申请号：AU2018200152
申请日：2018-01-08
Applicant: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH
Inventor： PEH RUEY FENG , CHEW JING MING , LOKE WEI LING FIONA , TAY HSIEN TS'UNG
IPC: A61M5/158
Abstract: According to various embodiments, a method and system to obtain access to a blood vessel underneath a skin layer that may preserve lifespan of the blood vessel and reduce executional skill variability may be provided. The method includes placing a guiding portion between the blood vessel and the skin layer; and configuring the guiding portion to receive and guide a needle to reach the same location of the blood vessel repeatedly and consistently; and forming a resultant scarred track between the blood vessel and the skin layer as the guiding portion is resorbed over time. The system includes a vascular access device configurable to first possess strength to penetrate through a tissue layer, subsequently possess flexibility to conform to the surrounding tissue beneath the tissue layer; and a guiding portion which may be resorbable, wherein the inlet includes a larger diameter compared to the outlet.
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公开(公告)号：AU2012329403B2
公开(公告)日：2015-08-20
申请号：AU2012329403
申请日：2012-10-24
Inventor： RAMADAS SENTHIL KUMAR , SHANMUGAVEL SARAVAN
Abstract: Disclosed is an encapsulation barrier stack, capable of encapsulating a moisture and/or oxygen sensitive article and comprising a multilayer film, wherein the multilayer film comprises: one or more barrier layer(s) having low moisture and/or oxygen permeability, and one or more sealing layer(s) arranged to be in contact with a surface of the at least one barrier layer, thereby covering defects present in the barrier layer, wherein the one or more sealing layer(s) comprise(s) a plurality of encapsulated nanoparticles, the nanoparticles being reactive in that they are capable of interacting with moisture and/or oxygen to retard the permeation of moisture and/or oxygen through the defects present in the barrier layer. The encapsulation of the particles can be obtained by polymerising a polymerisable compound (a monomeric or a polymeric compound with polymerisible groups or) cross-linking a cross-linkable compound on the surface of the reactive nanoparticles.
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Patent Agency Ranking
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公开(公告)号：AU2002309461B2
公开(公告)日：2008-07-17
申请号：AU2002309461
申请日：2002-06-14
Inventor： LEONG KAM WENG , HAI-QUAN MAO , KUAN CHEE MUN
IPC: C12M1/00 , A61K47/48 , A61L27/00 , A61L27/28 , A61L27/38 , A61L27/50 , A61L27/54 , C12N5/00 , C12N5/071
Abstract: The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization is achieved by covalent conjugation of biofunctional igands and/or cell growth factors that are crucial for cell attachment, proliferation and functions. Biofunctional fibers could be fabricated into three-dimensional scaffolds. Polymer fibers described here comprise of biocompatible polymers that are either biodegradable ornon-biodegradable. This patent also describes a series of new biodegradable polyphosphoramidates for the processing of biodegradable fibers. Scaffolds made of non-biodegradable functional fibers could be used for in vitro cell culture (for example, ex vivo cell expansion), while biodegradable functional fibers could be fabricated into tissue engineering scaffolds.
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公开(公告)号：SG10201805438TA
公开(公告)日：2020-01-30
申请号：SG10201805438T
申请日：2018-06-25
Inventor： KAMBIZ ANSARI MAHABADI , DONG ZHAOGANG
Abstract: A diamond comprising of: at least one surface; and a plurality of nanostructures formed on the at least one surface of the diamond, wherein the plurality of nanostructures generates one or more structural colours on the surface of the diamond.
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公开(公告)号：SG11201901135PA
公开(公告)日：2019-03-28
申请号：SG11201901135P
申请日：2017-08-10
Applicant: 1 AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH
Inventor： BIGLIARDI PAUL , WANG ZHIPING , WU RUIGE , ALBERTI MASSIMO , WU BO , BIGLIARDI-QI MEI , GOPU SRIRAM , RAMASAMY SRINIVAS , DANCIK YURI HEBERT
Abstract: The present disclosure describes a microfluidic chip for culturing and in vitro testing of 3D organotypic cultures. The tests may be performed directly on the organotypic culture in the microfluidic chip. The microfluidic chip includes at least one microfluidic unit which includes two fluidic compartments, such as upper and lower, separated by a permeable supporting structure, one or more access opening for the fluidic compartments, and a set of lids interchangeable with a set of insets. The permeable support structure serves as a support for the organotypic culture. The upper and lower compartments may include inlets and outlets which allow fluids to be perfused into the lower compartment and fluids to be perfused into the upper compartment. The access opening may be closed with a lid or accommodate an inset.
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公开(公告)号：AU2012337406A1
公开(公告)日：2014-06-19
申请号：AU2012337406
申请日：2012-11-19
Inventor： BATAGOV ARSEN , IVSHINA ANNA , KUZNETSOV VLADIMIR
IPC: C12Q1/68
Abstract: The present invention relates to an in vitro method for diagnosing epithelial ovarian cancer, cervical cancer, endometriosis, clear cell renal carcinoma and/or predisposition to epithelial ovarian cancer in a subject, the method comprising determining in a sample of the subject gene expression level of at least one gene in the MDS 1 and EVI1 complex (MECOM) locus; and/or copy number of at least one gene in the MECOM locus; wherein the level against at least one expression cutoff value and/or copy number against at least one copy number cutoff value are indicative of the subject having epithelial ovarian cancer, cervical cancer, endometriosis, clear cell renal carcinoma and/or a predisposition to epithelial ovarian cancer cervical cancer, endometriosis, clear cell renal carcinoma and/or determining whether the ovarian cancer in the subject is primary or secondary ovarian cancer and/or a risk of the disease progression after surgery treatment, and/or an effectiveness of post-surgery chemotherapy.
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