公开(公告)号：AU2002309461B2

公开(公告)日：2008-07-17

申请号：AU2002309461

申请日：2002-06-14

Applicant: ASTARSTARSTAR AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH

Inventor： LEONG KAM WENG ,  HAI-QUAN MAO ,  KUAN CHEE MUN

IPC: C12M1/00 ,  A61K47/48 ,  A61L27/00 ,  A61L27/28 ,  A61L27/38 ,  A61L27/50 ,  A61L27/54 ,  C12N5/00 ,  C12N5/071

Abstract: The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization is achieved by covalent conjugation of biofunctional igands and/or cell growth factors that are crucial for cell attachment, proliferation and functions. Biofunctional fibers could be fabricated into three-dimensional scaffolds. Polymer fibers described here comprise of biocompatible polymers that are either biodegradable ornon-biodegradable. This patent also describes a series of new biodegradable polyphosphoramidates for the processing of biodegradable fibers. Scaffolds made of non-biodegradable functional fibers could be used for in vitro cell culture (for example, ex vivo cell expansion), while biodegradable functional fibers could be fabricated into tissue engineering scaffolds.