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公开(公告)号：PT1088077E
公开(公告)日：2007-10-29
申请号：PT99926984
申请日：1999-06-17
Applicant: ID LELYSTAD INST DIERHOUDERIJ
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公开(公告)号：CA2364686C
公开(公告)日：2007-04-24
申请号：CA2364686
申请日：2000-02-09
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： LANGEVELD JOHANNES PIETER MARI , SMITS MARINUS ADRIANUS , BOSSERS ALEXANDER , SCHREUDER BRAM EDWARD CORNELIS , VAN KEULEN LUCIEN JOHANNES MAT , JACOBS JORG GUNTHER , GARSSEN GERRIT JAN
Abstract: The invention is related to diagnostic methods for detecting transmissible spongiform encephalopathies (TSEs) such as BSE and scrapie and related disea se in humans. The invention provides use of guanidine thiocyanate (gdnSCN) or a functional equivalent thereof for treating at least one sample derived from a mammal, including humans for reducing the risk of scoring a false-positive test result in testing said sample for the presence or absence of aberrant prion protein.
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93.发明专利
公开(公告)号：CA2552273A1
公开(公告)日：2007-01-13
申请号：CA2552273
申请日：2006-07-12
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： MROZ ZDZISLAW , KOOPMANS SIETSE JAN
IPC: C12Q1/00 , A01K67/027 , A61K31/155
Abstract: The invention provides a method for generating a type II diabetes mellit us and/or Syndrome X model in pigs. A method of the invention comprises partially destructing pancreatic beta-cells in pigs. From said pigs, a pig i s preferably selected that comprises a fasting plasma glucose level higher tha n 6 mmol/L. The invention further provides a pig according to the invention and uses thereof.
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公开(公告)号：ZA200210354B
公开(公告)日：2004-04-20
申请号：ZA200210354
申请日：2002-12-20
Applicant: BAYER AG ID LELYSTAD B V
Inventor： SCHLAPP TOBIAS , MARIA RIJSEWIJK FRANCISCUS ANT
IPC: A61K39/15 , A61P31/12 , C12N15/09 , C07K14/18 , C12N5/02 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/40 , A61K , C12N
Abstract: The present invention relates to bovine viral diarrhea virus (BVDV) virus-like particles, a polycistronic RNA and DNA corresponding thereto encoding a polyprotein of BVDV structural proteins that are sufficient to form BVDV virus-like particles, a viral vector encoding factors and structural proteins for the assembly of BVDV virus-like particles, a vaccine comprising BVDV virus-like particles, a diagnostic kit and methods for preparing BVDV virus-like particles.
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公开(公告)号：AU2003202826A1
公开(公告)日：2003-07-24
申请号：AU2003202826
申请日：2003-01-13
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： THOLE JELLE EGBERTUS RUDOLFUS , WILLEMSEN PETRUS THEODORUS JOH , WESTERVEEN SJOUKJE FETSJE , BAKKER DOUWE , ZIJDERVELD FRED GOVERT VAN
IPC: G01N33/53 , A61K39/00 , A61K39/005 , A61K39/02 , A61K39/04 , A61K39/085 , A61K39/09 , A61K39/108 , A61K39/135 , A61K39/145 , A61K39/155 , A61K39/215 , A61K39/245 , A61P31/04 , A61P31/06 , A61P31/12 , C07K14/35 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12Q1/02 , C12Q1/04 , C12Q1/68 , G01N33/569
Abstract: The present invention relates to nucleic acid sequences encoding Mycobacterium avium subspecies paratuberculosis proteins, to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to Mycobacterium avium subspecies paratuberculosis proteins and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines. Moreover, the inventions relates to the use of said nucleic acid sequences, proteins, or antibodies for diagnostic or vaccination purposes. Also, the invention relates to methods for the preparation of such vaccines. Finally the invention relates to diagnostic kits comprising such nucleic acids, proteins or antibodies against such proteins.
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Patent Agency Ranking
公开(公告)号：BR0112020A
公开(公告)日：2003-05-13
申请号：BR0112020
申请日：2001-06-15
Applicant: BAYER AG , ID LELYSTAD B V
Inventor： SCHLAPP TOBIAS , RIJSEWIJK FRANCISCUS ANTONIUS
IPC: C12N15/09 , A61K39/15 , A61P31/12 , C07K14/18 , C12N5/02 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/40 , C12N15/869 , A61K39/12
Abstract: The present invention relates to bovine viral diarrhea virus (BVDV) virus-like particles, a polycistronic RNA and DNA corresponding thereto encoding a polyprotein of BVDV structural proteins that are sufficient to form BVDV virus-like particles, a viral vector encoding factors and structural proteins for the assembly of BVDV virus-like particles, a vaccine comprising BVDV virus-like particles, a diagnostic kit and methods for preparing BVDV virus-like particles.
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公开(公告)号：AU2002230275A1
公开(公告)日：2002-08-12
申请号：AU2002230275
申请日：2002-01-31
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： SMITH HILDA ELIZABETH
Abstract: The invention relates to the field of the diagnosis of and vaccination against Streptococcal infections, and to the detection of virulence markers of Streptococci. The invention discloses a method for modulating virulence of a Streptococcus comprising modifying a genomic fragment of the Streptococcus, wherein the genomic fragment comprises at least a functional part of a fragment identifiable by hybridization in Streptococcus suis to a nucleic acid or fragment thereof.
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公开(公告)号：CA2421580A1
公开(公告)日：2002-03-21
申请号：CA2421580
申请日：2001-09-11
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： MELOEN ROBERT HANS , TURKSTRA JOUWERT ANNE , OONK HENDRICA BERENDINA
IPC: A61K39/00 , A61K38/00 , A61P15/00 , A61P35/00 , C07K14/00 , C07K14/575 , C07K14/72 , C07K16/00 , C07K16/26 , C07K7/23 , A61K38/09
Abstract: A peptide that comprises a modified GnRH decapeptide sequence which allows f or a testosterone level that is essentially non-detectable after vaccination wi th the peptide in a suitable dosage and/or allows for a immunogenic response th at allows for the effective discrimination between GnRH-I and GnRH-II and a method for the immunocastration of pigs and for the treatment of prostate cancers of humans
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公开(公告)号：AU5893801A
公开(公告)日：2001-12-03
申请号：AU5893801
申请日：2001-05-21
Applicant: ID LELYSTAD INST DIERHOUDERIJ
IPC: C12N15/09 , A61K39/00 , A61K39/12 , A61P11/00 , A61P15/00 , A61P31/14 , C07K14/08 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/40 , C12N15/86
Abstract: The invention relates to the field of Arteriviruses and vaccines directed against infections caused by these viruses. The invention provides an Arterivirus-like particle comprising at least a first structural protein derived from a first Arterivirus and a second structural protein wherein said second structural protein is at least partly not derived from said first Arterivirus.
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公开(公告)号：HU0102429A2
公开(公告)日：2001-10-28
申请号：HU0102429
申请日：1999-06-17
Applicant: ID LELYSTAD INST DIERHOUDERIJ
Inventor： DE LEEUW OLAV SVEN , GIELKENS ARNOUD LEONARD JOSEF , KOCH GUUS , PEETERS BERNARDUS PETRUS HUBER
IPC: C12N15/09 , A61K39/17 , A61K48/00 , A61P31/12 , C07K14/125 , C12N7/00 , C12N7/01 , C12N15/45 , C12N15/86 , C12Q1/70
Abstract: The invention relates to the process for generating infectious Newcastle disease virus (NDV) entirely from cloned full-length cDNA and to the use of vaccines and diagnostic assays generated with and derived from said process. The process offers the possibility to modify the NDV genome by means of genetic modification and allows the introduction of mutations, deletions, and/or insertions. The process can be used to modify the virulence of NDV, thereby generating new attenuated live vaccines with enhanced properties. The process can be used to modify the antigenic make-up of NDV, thus allowing the generation of live NDV marker vaccines which can be serologically distinguished from NDV field strains.
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