公开(公告)号：US20120177742A1

公开(公告)日：2012-07-12

申请号：US13340472

申请日：2011-12-29

Applicant: James B. McCLAIN ,  Charles Douglas Taylor ,  Brett G. Zani ,  Timothy Charles Kiorpes

Inventor： James B. McCLAIN ,  Charles Douglas Taylor ,  Brett G. Zani ,  Timothy Charles Kiorpes

IPC: A61K9/00 ,  B05D7/00 ,  A61K31/436 ,  A61P37/06 ,  B82Y5/00

CPC classification number: B82Y5/00 ,  A61K31/436 ,  A61L29/085 ,  A61L29/143 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/624 ,  A61L2300/802 ,  A61L2400/12

Abstract: Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.

Abstract translation: 因此，装置，涂层和方法包括用于将活性剂的纳米颗粒递送到治疗部位的医疗装置。 医疗装置上的涂层包括活性剂纳米颗粒，其将涂层递送至治疗部位，并在至少一天内将活性剂纳米颗粒释放到治疗部位。 涂层可以包括聚合物，表面活性剂和纳米颗粒。 可以通过形成纳米乳液来制备涂层。 涂层可以包含包封在聚合物中的活性剂纳米颗粒的包封的活性剂纳米颗粒。 涂层可能具有正表面电荷。 涂层可在至少约一天内将活性剂纳米颗粒递送至治疗部位。 涂层可以由表面活性剂和纳米颗粒混合物形成。 活性剂纳米颗粒可以使用静电捕获沉积在医疗装置上。

公开(公告)号：US20120064124A1

公开(公告)日：2012-03-15

申请号：US13229473

申请日：2011-09-09

Applicant: James B. McClain ,  Charles Douglas Taylor ,  Wenda C. Carlyle

Inventor： James B. McClain ,  Charles Douglas Taylor ,  Wenda C. Carlyle

IPC: A61K9/00 ,  A61P27/16 ,  A61P19/02 ,  A61P15/00 ,  A61P13/00 ,  A61M5/32 ,  A61P37/08 ,  A61P27/02 ,  A61P31/00 ,  A61P37/06 ,  A61M5/00 ,  A61M5/30 ,  A61K39/00 ,  A61P35/00

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/7007 ,  A61K31/436

Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.

Abstract translation: 提供了包含至少一种聚合物和至少一种活性剂的药物递送组合物; 其中所述活性剂以结晶形式存在于所述组合物的外表面的至少一个区域上，并且其中调节活性剂表面含量以提供选定的活性剂释放曲线。

公开(公告)号：US20110257732A1

公开(公告)日：2011-10-20

申请号：US13086335

申请日：2011-04-13

Applicant: James B. McClain ,  Douglas Taylor

Inventor： James B. McClain ,  Douglas Taylor

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/63

Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

Abstract translation: 本文提供的装置包括：a。 支架; b。 在所述支架框架上的多个层以形成所述装置; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

公开(公告)号：US20110159069A1

公开(公告)日：2011-06-30

申请号：US12648106

申请日：2009-12-28

Applicant: Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

Inventor： Wendy J. Shaw ,  Clement R. Yonker ,  John L. Fulton ,  Barbara J. Tarasevich ,  James B. McClain ,  Doug Taylor

IPC: A61F2/02 ,  A61K31/727 ,  A61K38/16 ,  A61F11/00 ,  A61P43/00

CPC classification number: A61L31/10 ,  A61K31/727 ,  A61L31/16 ,  A61L2300/42 ,  A61L2400/18

Abstract: A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

Abstract translation: 一种具有氧化表面的基底和与氧化表面共价结合的硅烷衍生物涂层的医用植入装置。 生物活性剂与硅烷衍生物涂层共价键合。 一种可植入支架装置，其包括具有氧化表面的支架芯，其具有与其共价键合的硅烷衍生物层。 包含聚乙二醇（PEG）的间隔层与硅烷衍生物层共价键合，蛋白质与PEG共价键合。 一种制造医疗植入装置的方法，包括提供具有表面的基底，氧化表面并与衍生的硅烷反应以形成共价键合到该表面的硅烷涂层。 然后将生物活性剂共价键合到硅烷涂层。 在特定情况下，生物吸收性聚合物和/或药剂的附加涂层沉积在生物活性剂上。

公开(公告)号：US20100256746A1

公开(公告)日：2010-10-07

申请号：US12729603

申请日：2010-03-23

Applicant: Douglas Taylor ,  James B. McClain ,  Edward E. Schmitt

Inventor： Douglas Taylor ,  James B. McClain ,  Edward E. Schmitt

IPC: A61F2/06 ,  C08G63/02 ,  A61K31/436 ,  B05D7/00

CPC classification number: A61L31/10 ,  A61K31/435 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2420/08 ,  B05D3/12 ,  B05D2254/06 ,  C08G63/06 ,  C08G63/08 ,  C08G63/90 ,  C08G2150/20 ,  C08G2230/00 ,  C08J7/047 ,  C08L67/04 ,  C09D5/033 ,  C09D167/04

Abstract: Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities.

Abstract translation: 本文提供的是包含基本上不含酸性杂质的聚（α-羟基羧酸）的组合物，其中聚（α-羟基羧酸）选自聚（D，L-乳酸 - 共 - 乙醇酸），聚（L-乳酸 酸），聚（D-乳酸）和聚（D，L-乳酸）。 还提供了一种装置，其包括：基底和涂层，其中所述涂层包含基本上不含酸性杂质的聚（D，L-乳酸 - 共 - 乙醇酸）。

公开(公告)号：US20100015200A1

公开(公告)日：2010-01-21

申请号：US12504597

申请日：2009-07-16

Applicant: James B. McClain ,  Douglas Taylor ,  John Neet

Inventor： James B. McClain ,  Douglas Taylor ,  John Neet

IPC: A61F2/02 ,  A61K38/17 ,  A61K38/43 ,  A61K38/19 ,  A61K38/18 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/20 ,  A61K31/715 ,  A61K35/12 ,  A61K48/00

CPC classification number: A61L29/16 ,  A61F2002/30535 ,  A61F2250/0058 ,  A61K9/0024 ,  A61K9/0034 ,  A61K31/20 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/715 ,  A61K38/00 ,  A61L17/005 ,  A61L17/145 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/14 ,  A61L29/148 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2300/63 ,  A61L2420/08 ,  A61M2025/105

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

Abstract translation: 提供一种涂覆的可植入医疗装置，包括：基底; 以及设置在所述基底上的涂层，其中所述涂层包含至少一种聚合物和至少一种治疗上需要的形态和/或至少一种活性生物试剂和任选的一种或多种药物载体的药剂; 其中基本上所有的药剂和/或活性生物制剂都保留在所述涂层内和所述衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将所述医疗装置部署在所述受试者的身体中时 所述药剂和/或活性生物剂的一部分与所述聚合物的至少一部分和/或所述药物载体的至少一部分在所述介入部位递送。

公开(公告)号：US06953041B2

公开(公告)日：2005-10-11

申请号：US10267276

申请日：2002-10-09

Applicant: James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Mark I. Wagner

Inventor： James P. DeYoung ,  James B. McClain ,  Stephen M. Gross ,  Mark I. Wagner

IPC: C23F1/10 ,  H01L21/306 ,  H01L21/311 ,  H01L21/3205 ,  H01L21/3213 ,  B08B6/00 ,  C25F1/00

CPC classification number: C23F1/10 ,  H01L21/02052 ,  H01L21/31116 ,  H01L21/32051 ,  H01L21/32134

Abstract: Compositions useful for cleaning metal from a substrate or coating metal onto a substrate are described: Such compositions comprise (a) a densified carbon dioxide continuous phase; (b) a polar discrete phase in said carbon dioxide continuous phase; (c) a metal in said discrete phase (i.e., a metal removed from the substrate, or to be coated onto the substrate); (d) at least one ligand in said continuous phase, said discrete phase, or both said continuous and said discrete phase.

Abstract translation: 描述了用于从基材或涂覆金属清洗金属到基底上的组合物：这样的组合物包含（a）致密化的二氧化碳连续相; （b）所述二氧化碳连续相中的极性离散相; （c）所述离散相中的金属（即，从基底去除或要涂覆在基底上的金属）; （d）所述连续相中的至少一种配体，所述离散相或所述连续和所述离散相两者。

公开(公告)号：US06782900B2

公开(公告)日：2004-08-31

申请号：US09951353

申请日：2001-09-13

Applicant: James DeYoung ,  James B. McClain ,  Michael E. Cole ,  Steven Lee Worm ,  David Brainard

Inventor： James DeYoung ,  James B. McClain ,  Michael E. Cole ,  Steven Lee Worm ,  David Brainard

IPC: B08B300

CPC classification number: C23G5/00 ,  B08B7/0021 ,  B81C1/00841 ,  B81C2201/117 ,  H01L21/02063 ,  H01L21/67051 ,  Y10S134/902

Abstract: An apparatus for cleaning a microelectronic substrate includes a pressure chamber, a supply of a process liquid including dense phase CO2 fluidly connected to the chamber and a distilling system. Distilling system includes a still fluidly connected to the chamber and operative to separate CO2 from the process fluid. The distilling system is operative to re-introduce the separated CO2 into the chamber or a further chamber.

Abstract translation: 用于清洁微电子衬底的装置包括压力室，包括流体连接到室的致密相CO 2的处理液的供应和蒸馏系统。 蒸馏系统包括仍然流体连接到室并且用于将CO 2与工艺流体分离。 蒸馏系统可操作以将分离的CO 2重新引入室或另外的室中。

公开(公告)号：US06669785B2

公开(公告)日：2003-12-30

申请号：US10146617

申请日：2002-05-15

Applicant: James P. DeYoung ,  Stephen M. Gross ,  Mark I. Wagner ,  James B. McClain

Inventor： James P. DeYoung ,  Stephen M. Gross ,  Mark I. Wagner ,  James B. McClain

IPC: C23G102

CPC classification number: C11D7/08 ,  B08B7/0021 ,  C11D7/02 ,  C11D11/0047 ,  H01L21/31116 ,  H01L21/31133

Abstract: A method of cleaning a microelectronic substrate is carried out by providing a cleaning fluid, the cleaning fluid comprising an adduct of hydrogen fluoride with a Lewis base in a carbon dioxide solvent; and then cleaning the substrate by contacting the substrate to the cleaning fluid for a time sufficient to clean the substrate.

Abstract translation: 清洁微电子基板的方法是通过提供一种清洗流体来进行的，该清洗流体包括氟化氢与路易斯碱在二氧化碳溶剂中的加合物; 然后通过使衬底与清洁流体接触足以清洁衬底的时间来清洁衬底。

公开(公告)号：US06562146B1

公开(公告)日：2003-05-13

申请号：US09932063

申请日：2001-08-17

Applicant: James P. DeYoung ,  James B. McClain ,  Stephen M. Gross

Inventor： James P. DeYoung ,  James B. McClain ,  Stephen M. Gross

IPC: B08B300

CPC classification number: C23G5/00 ,  B08B7/0021 ,  H01L21/02063 ,  Y10S134/902 ,  Y10S438/906

Abstract: A method of cleaning and removing water and entrained solutes during a manufacturing process from a microelectronic device such as a resist-coated semiconductor substrate, a MEM's device, or an optoelectronic device comprising the steps of: (a) providing a partially fabricated integrated circuit, MEM's device, or optoelectronic device having water and entrained solutes on the substrate; (b) providing a densified (e.g., liquid or supercritical) carbon dioxide drying composition, the drying composition comprising carbon dioxide and a drying adjunct, the drying adjunct selected from the group consisting of cosolvents, surfactants, and combinations thereof; (c) immersing the surface portion in the densified carbon dioxide drying composition; and then (d) removing the drying composition from the surface portion. Process parameters are controlled so that the drying composition is maintained as a homogeneous composition during the immersing step, the removing step, or both the immersing and removing step, without substantial deposition of the drying/cleaning adjunct or entrained solutes on the substrate.

Abstract translation: 一种在制造过程中从诸如抗蚀剂涂覆半导体衬底，MEM器件或光电器件的微电子器件清洗和除去水和夹带溶质的方法，包括以下步骤：（a）提供部分制造的集成电路， MEM的装置或在基板上具有水和夹带溶质的光电装置; （b）提供致密化（例如液体或超临界）二氧化碳干燥组合物，所述干燥组合物包含二氧化碳和干燥助剂，所述干燥助剂选自助溶剂，表面活性剂及其组合; （c）将表面部分浸入致密二氧化碳干燥组合物中; 然后（d）从表面部分除去干燥组合物。 控制工艺参数，使得干燥组合物在浸渍步骤，去除步骤或浸渍和除去步骤期间保持为均匀的组合物，而基本上不沉积干燥/清洁助剂或夹带的溶质。