公开(公告)号：US11965035B2

公开(公告)日：2024-04-23

申请号：US17255692

申请日：2019-06-26

Applicant: Kyowa Kirin Co., Ltd. ,  KAGOSHIMA UNIVERSITY

Inventor： Nobuaki Takahashi ,  Ryosuke Nakano ,  Sayaka Maeda ,  Yuji Ito

IPC: C07K16/30 ,  C12N5/16 ,  G01N33/50

CPC classification number: C07K16/3053 ,  C12N5/16 ,  G01N33/5058 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2319/33

Abstract: The invention relates to an antibody which binds to chondroitin sulfate proteoglycan 5 (CSPG5) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

公开(公告)号：US20230414718A1

公开(公告)日：2023-12-28

申请号：US18253651

申请日：2021-11-18

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Ken-ichiro KOSAI ,  Eriko MATSUDA

IPC: A61K38/18 ,  C12N15/86 ,  C07K14/475 ,  A61P3/10 ,  A61P1/18

CPC classification number: A61K38/1833 ,  C12N15/86 ,  C07K14/4753 ,  A61P3/10 ,  A61P1/18

Abstract: An agent for protecting and/or regenerating pancreatic β cells in a mammal with diabetes, containing a recombinant viral vector expressing a hepatocyte growth factor (HGF), wherein the agent is administered at a dose of 1010-1012 virus particles (vp)/kg body weight, and the viral vector contains a nucleic acid encoding HGF downstream of a promoter with transcriptional activity capable of affording a therapeutically effective blood HGF level at said dose is provided by the present invention.

公开(公告)号：US11643474B2

公开(公告)日：2023-05-09

申请号：US17264577

申请日：2019-08-01

Applicant: KAGOSHIMA UNIVERSITY ,  DAICEL CORPORATION

Inventor： Yuji Ito ,  Seiichi Uchimura ,  Hiromichi Okura

IPC: C07K1/22 ,  C07K14/435 ,  C07K17/00 ,  C07K19/00 ,  C07K7/08

CPC classification number: C07K19/00 ,  C07K1/22 ,  C07K7/08 ,  C07K14/43595 ,  C07K17/00

Abstract: An object of the present invention is to provide a method by which a peptide having a specific binding capability that can be used for purification of a target molecule can be produced at a low cost, and specifically relates to a peptide fusion protein including one or more peptides having specific binding capability and a scaffold protein, the peptide being inserted into the amino acid sequence of the scaffold protein directly or via a peptide linker, and/or being linked to the N-terminal and/or C-terminal of the scaffold protein.

公开(公告)号：US11571416B2

公开(公告)日：2023-02-07

申请号：US16603907

申请日：2018-04-13

Applicant: KAGOSHIMA UNIVERSITY

Inventor： Robert A. Davey ,  Yasuteru Sakurai ,  Masanori Baba ,  Norikazu Sakakibara

IPC: A61K31/4706 ,  A61P31/14 ,  A61K31/4709 ,  A61K31/473 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541

Abstract: Described herein are pharmaceutical compositions capable of blocking entry of a virus into a host cell and containing one or more compounds of the general formula I or a pharmaceutically acceptable derivative thereof and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat viral infections.

公开(公告)号：US11491219B2

公开(公告)日：2022-11-08

申请号：US16652935

申请日：2018-10-04

Applicant: TOKO YAKUHIN KOGYO CO., LTD. ,  TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE ,  JAPAN as represented by DIRECTOR GENERAL of National Institute of Infectious Diseases ,  KAGOSHIMA UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY

Inventor： Taizou Kamishita ,  Takashi Miyazaki ,  Michinori Kohara ,  Takahiro Sanada ,  Yoichi Hiasa ,  Osamu Yoshida ,  Kyoko Kohara ,  Hideki Hasegawa

IPC: A61P31/20 ,  A61K47/32 ,  A61K39/29 ,  A61K9/00

Abstract: The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.

公开(公告)号：US20220347600A1

公开(公告)日：2022-11-03

申请号：US17619919

申请日：2020-05-20

Applicant: ASADA MESH CO.,LTD. ,  KAGOSHIMA UNIVERSITY

Inventor： Yoshifumi MIZUGUCHI ,  Shinichi SHIMOKOMAKI ,  Susumu NII ,  Kei MIZUTA

IPC: B01D17/04 ,  C02F1/40

Abstract: A coalescer is installable on a flow path for a target liquid to be treated containing oil droplets. The coalescer includes sheets of metal mesh with, for example, a plain weave, twill weave, or thick weave stacked on one another to form mesh layers and interlayer portions between the layers. The metal mesh has a surface extending along a flow of the target liquid. Oil droplets come into contact with either or both of warp wires and weft wires to form an oil film that moves downstream with the target liquid flow. The oil film grows into larger droplet particles at downstream ends of the mesh layers. The larger droplet particles leave the coalescer with the flow of the target liquid.

公开(公告)号：US20220152187A1

公开(公告)日：2022-05-19

申请号：US17438178

申请日：2020-03-13

Applicant: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE ,  KAGOSHIMA UNIVERSITY ,  NAGASAKI UNIVERSITY

Inventor： Michinori KOHARA ,  Fumihiko YASUI ,  Daisuke YAMANE ,  Kyoko KOHARA ,  Kouichi MORITA ,  Yasuhiro YASUTOMI ,  Koji ISHII

IPC: A61K39/12 ,  A61P31/14 ,  C12N15/113

Abstract: The present invention provides a recombinant Vaccinia virus as a dengue virus vaccine that can be used as a therapeutic or prophylactic agent in the clinic. This recombinant Vaccinia virus is characterized by including: all or part of a cDNA that encodes a non-structural protein from a dengue virus; and an expression promoter.

公开(公告)号：US20220025044A1

公开(公告)日：2022-01-27

申请号：US17399354

申请日：2021-08-11

Applicant: Kyowa Kirin Co., Ltd. ,  KAGOSHIMA UNIVERSITY

Inventor： Nobuaki TAKAHASHI ,  Ryosuke NAKANO ,  Sayaka MAEDA ,  Yuji ITO

IPC: C07K16/28 ,  A61K47/10 ,  A61K47/36 ,  C12N5/12 ,  G01N33/563

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

公开(公告)号：US20210332152A1

公开(公告)日：2021-10-28

申请号：US17264577

申请日：2019-08-01

Applicant: KAGOSHIMA UNIVERSITY ,  DAICEL CORPORATION

Inventor： Yuji ITO ,  Seiichi UCHIMURA ,  Hiromichi OKURA

IPC: C07K19/00 ,  C07K14/435 ,  C07K7/08 ,  C07K1/22 ,  C07K17/00

Abstract: An object of the present invention is to provide a method by which a peptide having a specific binding capability that can be used for purification of a target molecule can be produced at a low cost, and specifically relates to a peptide fusion protein including one or more peptides having specific binding capability and a scaffold protein, the peptide being inserted into the amino acid sequence of the scaffold protein directly or via a peptide linker, and/or being linked to the N-terminal and/or C-terminal of the scaffold protein.

公开(公告)号：US20210228712A1

公开(公告)日：2021-07-29

申请号：US16630811

申请日：2018-07-13

Applicant: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE ,  NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY ,  KAGOSHIMA UNIVERSITY ,  BEACLE INC

Inventor： Michinori Kohara ,  Takahiro Sanada ,  Yoichi Hiasa ,  Kyoko Kohara ,  Yasumasa Goh ,  Yasunori Oda

IPC: A61K39/29 ,  A61P31/20

Abstract: A hepatitis B vaccine comprising a surface antigen particle that has only hepatitis B virus L protein or a variant thereof assembling on a lipid membrane to form the particle.