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    COMPOSITIONS AND METHODS FOR PROTEIN STRUCTURAL DETERMINATIONS
    91.
    发明申请
    COMPOSITIONS AND METHODS FOR PROTEIN STRUCTURAL DETERMINATIONS 审中-公开
    蛋白质结构测定的组合物和方法

    公开(公告)号：WO1994018339A1

    公开(公告)日：1994-08-18

    申请号：PCT/US1994001329

    申请日：1994-02-07

    Applicant: MARTEK BIOSCIENCES CORPORATION ,  BROWN, Jonathan, Miles

    Inventor： MARTEK BIOSCIENCES CORPORATION

    IPC: C12P13/04

    CPC classification number: G01N33/68 ,  C07B59/001 ,  C07K2299/00 ,  C12N1/12 ,  C12P13/04 ,  C12Q1/04 ,  G01N33/534 ,  G01N33/58 ,  G01N33/6803 ,  Y02P20/55 ,  Y10T436/105831

    Abstract: A method for determining three-dimensional structural information of a protein involves producing the protein in a form substantially labeled with C or N or both or substantially labeled with N and C and partially labeled with H and subjecting the protein to nuclear magnetic resonance spectroscopic analysis. The isotopically labeled protein is produced by a method which involves producing a substantially labeled microbial protein hydrolysate, subjecting the protein hydrolysate to cation exchange chromatography to produce a partially purified labeled amino acid mixture, subjecting the partially purified labeled amino acid mixture to anion exchange chromatography to produce a purified labeled amino acid mixture and supplementing the purified labeled amino acid mixture with isotopically labeled cysteine and optionally with isotopically labeled glutamine and asparagine.

    Abstract translation: 用于测定蛋白质的三维结构信息的方法包括以13 C或15 N或两者基本上标记的形式产生蛋白质，或者基本上用15 N和13 C标记，并部分地用 并使蛋白质进行核磁共振光谱分析。 同位素标记的蛋白质通过包括产生基本上标记的微生物蛋白质水解产物的方法产生，使蛋白质水解产物进行阳离子交换层析以产生部分纯化的标记氨基酸混合物，将部分纯化的标记氨基酸混合物进行阴离子交换色谱 产生纯化的标记的氨基酸混合物，并用同位素标记的半胱氨酸和任选与同位素标记的谷氨酰胺和天冬酰胺补充纯化的标记的氨基酸混合物。

    METHODS FOR IMPROVING COGNITIVE FUNCTION AND DECREASING HEART RATE
    94.
    发明申请
    METHODS FOR IMPROVING COGNITIVE FUNCTION AND DECREASING HEART RATE 审中-公开
    改善认知功能和降低心率的方法

    公开(公告)号：WO2010088700A1

    公开(公告)日：2010-08-05

    申请号：PCT/US2010/022952

    申请日：2010-02-02

    Applicant: MARTEK BIOSCIENCES CORPORATION ,  YURKO-MAURO, Karin

    Inventor： YURKO-MAURO, Karin

    IPC: A61K31/202 ,  A61P25/28

    CPC classification number: A61K31/232 ,  A61K31/202

    Abstract: The present invention is directed to methods of improving cognitive function in subjects having age related cognitive decline or mild cognitive impairment and to methods of decreasing heart rate in a subject by administering dosage forms comprising docosahexaenoic acid (DHA) substantially free of eicosapentaenoic acid (EPA).

    Abstract translation: 本发明涉及通过施用包含基本上不含二十碳五烯酸（EPA）的二十二碳六烯酸（DHA）的剂型来改善患有年龄相关认知衰退或轻度认知障碍的受试者的认知功能的方法和降低受试者心率的方法， 。

    COMPOSITIONS AND METHODS FOR REDUCING TRIGLYCERIDE LEVELS
    95.
    发明申请
    COMPOSITIONS AND METHODS FOR REDUCING TRIGLYCERIDE LEVELS 审中-公开
    用于降低TRIGLYCERIDE水平的组合物和方法

    公开(公告)号：WO2010040012A1

    公开(公告)日：2010-04-08

    申请号：PCT/US2009/059302

    申请日：2009-10-01

    Applicant: MARTEK BIOSCIENCES CORPORATION ,  RYAN, Alan, Stuart ,  NELSON, Edward, B. ,  LEE, Jung ,  RAMAN, Krishna

    Inventor： RYAN, Alan, Stuart ,  NELSON, Edward, B. ,  LEE, Jung ,  RAMAN, Krishna

    IPC: A61K31/232 ,  A61P3/06

    CPC classification number: A61K31/232 ,  A61K31/20 ,  A61K31/201 ,  A61K2300/00

    Abstract: The present invention is directed to methods of reducing plasma triglyceride level in subjects by administering docosahexaenoic acid (DHA). The method can comprise administering daily to the subject a dosage form comprising docosahexaenoic acid ester substantially free of eicosapentaenoic acid (EPA), wherein the DHA is derived from an algal source. In some embodiments, the method comprises administering daily to the subject a dosage form comprising DHA ester substantially free of EPA, wherein the DHA ester is about 60 % to about 99.5 % (w/w) of the total fatty acid content of the dosage form. In some embodiments, the method comprises administering daily to the subject a dosage form comprising about 200 mg to about 4 g of DHA ester substantially free of EPA. In some embodiments, the foregoing methods also result in a lowering of the amount of total cholesterol in the subject.

    Abstract translation: 本发明涉及通过施用二十二碳六烯酸（DHA）来减少受试者血浆甘油三酯水平的方法。 该方法可以包括向受试者施用基本上不含二十碳五烯酸（EPA）的二十二碳六烯酸酯的剂型，其中DHA来源于藻源。 在一些实施方案中，该方法包括向受试者施用包含基本上不含EPA的DHA酯的剂型，其中DHA酯为剂型总脂肪酸含量的约60％至约99.5％（w / w） 。 在一些实施方案中，该方法包括向受试者施用包含约200mg至约4g基本上不含EPA的DHA酯的剂型。 在一些实施方案中，前述方法还导致受试者中总胆固醇的量的降低。

    CAROTENE SYNTHASE GENE AND USES THEREFOR
    99.
    发明申请
    CAROTENE SYNTHASE GENE AND USES THEREFOR 审中-公开
    CAROTENE SYNTHASE基因及其用途

    公开(公告)号：WO2003097798A2

    公开(公告)日：2003-11-27

    申请号：PCT/US2003/015229

    申请日：2003-05-14

    Applicant: MARTEK BIOSCIENCES CORPORATION

    Inventor： WEAVER, Craig, A. ,  METZ, James, G. ,  KUNER, Jerry, M. ,  OVERTON, Frank, H., Jr.

    IPC: C12N

    CPC classification number: C12N9/001 ,  C12N9/00 ,  C12N9/0004

    Abstract: Described herein is a novel three domain gene from Schizochytrium , denoted carotene synthase, that encodes a protein with three different enzymatic activities; phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene, biologically active portions and homologues thereof, recombinant nucleic acid molecules, microorganisms and plants that have been genetically modified to increase or decrease the action of such gene, and methods of producing carotenoids and derivatives thereof or methods of producing microorganisms and lipid products lacking pigmentation using the knowledge of the carotene synthase described herein.

    Abstract translation: 本文描述的是来自裂殖酵母（Schizochytrium）的新型三结构域基因，表示胡萝卜素合成酶，其编码具有三种不同酶活性的蛋白质; 八氢番茄红素脱氢酶（PD），八氢番茄红素合成酶（PS）和番茄红素环化酶（LC）。 还描述了编码胡萝卜素合成酶，其同系物，由该基因编码的酶，生物活性部分及其同源物，已被遗传修饰以增加或减少该基因的作用的重组核酸分子，微生物和植物的分离基因 以及生产类胡萝卜素及其衍生物的方法或使用本文所述的胡萝卜素合酶的知识来生产缺乏色素沉淀的微生物和脂质产物的方法。

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