公开(公告)号：US20210052781A1

公开(公告)日：2021-02-25

申请号：US16962007

申请日：2019-01-16

Applicant: Micell Technologies, Inc.

Inventor： David W. Gaddy ,  Meagan M. Fagan ,  James B. McClain

IPC: A61L29/08 ,  B05B13/02

Abstract: Transfer rings for use in coating substrates and methods of utilizing same are disclosed. The transfer rings disclosed herein are useful in efficiently moving a plurality of substrates between different process chambers. For instance, the transfer rings are designed to collectively move a plurality of stents between coating and sintering chambers.

公开(公告)号：US10350391B2

公开(公告)日：2019-07-16

申请号：US15366108

申请日：2016-12-01

Applicant: Micell Technologies, Inc.

Inventor： James B. McClain ,  Charles Douglas Taylor ,  John Neet ,  Brett G. Zani

IPC: A61M31/00 ,  A61M37/00 ,  A61B17/20 ,  A61M25/10 ,  A61B17/3207 ,  A61L29/08 ,  A61L29/16 ,  A61B17/00 ,  A61B17/22

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

公开(公告)号：US20190209742A1

公开(公告)日：2019-07-11

申请号：US16218001

申请日：2018-12-12

Applicant: Micell Technologies, Inc.

Inventor： James B. McClain ,  Charles Douglas Taylor

IPC: A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61F2/82

CPC classification number: A61L31/10 ,  A61F2/82 ,  A61F2230/0069 ,  A61F2250/0067 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/04

Abstract: Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

公开(公告)号：US09981071B2

公开(公告)日：2018-05-29

申请号：US15284677

申请日：2016-10-04

Applicant: Micell Technologies, Inc.

Inventor： James B. McClain ,  Charles Douglas Taylor ,  John Neet

IPC: A61L29/16 ,  A61L29/08 ,  A61L31/10 ,  A61L31/08 ,  A61L31/16 ,  A61L29/14 ,  A61M25/10

CPC classification number: A61L29/16 ,  A61F2002/30535 ,  A61F2250/0058 ,  A61K9/0024 ,  A61K9/0034 ,  A61K31/20 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/715 ,  A61K38/00 ,  A61L17/005 ,  A61L17/145 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/14 ,  A61L29/148 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2300/63 ,  A61L2420/08 ,  A61M2025/105

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.

公开(公告)号：US20180000996A1

公开(公告)日：2018-01-04

申请号：US15634246

申请日：2017-06-27

Applicant: Micell Technologies, Inc.

Inventor： James B. McClain ,  Charles Douglas Taylor ,  Robert Rabiner

IPC: A61L31/10 ,  A61L31/14 ,  A61F2/91

CPC classification number: A61L31/10 ,  A61F2/86 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61L31/148

Abstract: A method for preparing a laminate coronary stent comprising: providing a stent framework; and depositing a plurality of layers on said stent framework to form said laminate coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer.

公开(公告)号：US20170196982A1

公开(公告)日：2017-07-13

申请号：US15471139

申请日：2017-03-28

Applicant: Micell Technologies, Inc.

Inventor： James B. McClain ,  Wenda C. Carlyle ,  Charles Douglas Taylor

IPC: A61K47/34 ,  A61K31/436 ,  A61K9/00

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/7007 ,  A61K31/436

Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.

公开(公告)号：US20170080191A1

公开(公告)日：2017-03-23

申请号：US15366108

申请日：2016-12-01

Applicant: Micell Technologies, Inc.

Inventor： James B. McClain ,  Charles Douglas Taylor ,  John Neet ,  Brett G. Zani

IPC: A61M25/10 ,  A61L29/16 ,  A61L29/08 ,  A61B17/3207

CPC classification number: A61M25/10 ,  A61B17/320725 ,  A61B2017/00893 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2017/22065 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61M2025/105

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

公开(公告)号：US20160374837A1

公开(公告)日：2016-12-29

申请号：US15241271

申请日：2016-08-19

Applicant: Micell Technologies, Inc.

Inventor： James B. McClain ,  Charles Douglas Taylor

IPC: A61F2/86 ,  A61L31/06 ,  A61K31/436 ,  A61L31/02 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61F2/86 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61K31/436 ,  A61L31/022 ,  A61L31/06 ,  A61L31/08 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/204 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/608 ,  A61L2300/63 ,  A61L2420/08 ,  C08L67/04

Abstract: Provided herein is a drug delivery system comprising: a. substrate; b. a plurality of components combined with the substrate to form the drug delivery system; wherein at least one components comprises a bioabsorbable polymer and at least one other component comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

Abstract translation: 本文提供的药物递送系统包括：a。 基质; b。 与所述基板组合的多个部件以形成所述药物递送系统; 其中至少一种组分包含生物可吸收聚合物，并且至少一种其它组分包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

公开(公告)号：US20160095726A1

公开(公告)日：2016-04-07

申请号：US14963834

申请日：2015-12-09

Applicant: Micell Technologies, Inc.

Inventor： James B. McClain ,  Charles Douglas Taylor

IPC: A61F2/86 ,  A61L31/02 ,  A61L31/10 ,  A61L31/08 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61F2/86 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61K31/436 ,  A61L31/022 ,  A61L31/06 ,  A61L31/08 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/204 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/608 ,  A61L2300/63 ,  A61L2420/08 ,  C08L67/04

Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

Abstract translation: 本文提供的装置包括：a。 支架; b。 在所述支架框架上的多个层以形成所述装置; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

公开(公告)号：US20150040827A1

公开(公告)日：2015-02-12

申请号：US14310960

申请日：2014-06-20

Applicant: Battelle Memorial Institute ,  Micell Technologies, Inc.

Inventor： John L. Fulton ,  George S. Deverman ,  Dean W. Matson ,  Clement R. Yonker ,  C. Douglas Taylor ,  James B. McClain ,  Joseph M. Crowley

IPC: B05B5/03

CPC classification number: B05B5/032 ,  B05D1/025 ,  B05D1/04 ,  B05D3/0486 ,  Y10T428/24372 ,  Y10T428/25 ,  Y10T428/31504 ,  Y10T428/31507 ,  Y10T428/31511 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31855 ,  Y10T428/31931 ,  Y10T428/31935 ,  Y10T428/31938

Abstract: This disclosure describes the application of a supplemental corona source to provide surface charge on submicrometer particles to enhance collection efficiency and micro-structural density during electrostatic collection.

Abstract translation: 本公开描述了补充电晕源的应用，以在亚微米颗粒上提供表面电荷，以增强静电收集期间的收集效率和微结构密度。