公开(公告)号：US20180078552A1

公开(公告)日：2018-03-22

申请号：US15566590

申请日：2016-04-14

Applicant: Francesco Turrini ,  Antonella Pantaleo ,  Purdue Research Foundation Office of Technology Commercialization

Inventor： Phillip S. Low ,  Francesco Turrini ,  Antonella Pantaleo

IPC: A61K31/506

CPC classification number: A61K31/506 ,  A61K31/505

Abstract: The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds that inhibit the spleen tyrosine kinase (SYK). In some embodiments a method is presented to prevent thrombosis in blood vessels of patients with a hemolytic disease comprising the step of: administrating to a patient having at least one hemolytic disease a therapeutically effective amount of at least one SYK inhibitor. In some embodiments the method includes repeatedly administering the SYK kinase inhibitor to a patient.

公开(公告)号：US20170326171A1

公开(公告)日：2017-11-16

申请号：US15443062

申请日：2017-02-27

Applicant: GEL-E,Inc. ,  University of Maryland, Office of Technology Commercialization ,  The General Hospital Corporation

Inventor： Kevin Diehn ,  Matthew Dowling ,  Srinivasa R. Raghavan ,  David R. King

IPC: A61K31/734 ,  A61K31/717 ,  A61K31/722 ,  A61K38/39

CPC classification number: A61K31/734 ,  A61K31/717 ,  A61K31/722 ,  A61K38/39

Abstract: A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic nature of the putty is tunable by the composition and enables the putty to conform to a variety of wound topographies. Likewise, a hemostatic polymer, for example chitosan or hydrophobically modified chitosan, is included in this matrix to impart hemostatic properties and tissue adhesive on the putty. The hemostatic polymers disclosed prevent microbial infection and are suitable for oxygen transfer required during normal wound metabolism.

公开(公告)号：US20150147468A1

公开(公告)日：2015-05-28

申请号：US14552535

申请日：2014-11-25

Applicant: University of Maryland, Office of Technology Commercialization

Inventor： Kevin Diehn ,  Chandamany Arya ,  Karl Engel ,  Matthew Furstenburg ,  Srinivasa R. Raghavan

IPC: C09D7/12 ,  A41D19/015 ,  C09D131/04

CPC classification number: A41D19/01558 ,  A41D2400/80 ,  A41D2500/54 ,  C09D105/04 ,  C09D105/08 ,  C09D131/04 ,  C08K5/053 ,  C08K5/09 ,  C08L5/08 ,  C08L31/04

Abstract: A formulation for coating surfaces, for example gloves, with a tacky film comprises a hydrophobically modified biopolymer, where the hydrophobic modifications of the biopolymer correspond to between 1 and 90% of available functional groups, a plasticizer, and a volatile solvent. The formulation quickly dries into a tacky film that provides an enhanced friction of the surface.

Abstract translation: 用于涂覆表面的制剂，例如手套，具有粘性膜包括疏水改性的生物聚合物，其中生物聚合物的疏水性修饰对应于1至90％的可用官能团，增塑剂和挥发性溶剂。 制剂快速干燥成粘性膜，提供表面增强的摩擦力。

公开(公告)号：US10398412B2

公开(公告)日：2019-09-03

申请号：US15562999

申请日：2015-03-31

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： Eliezer Azi Ben-Lavi ,  Aaron Fenster

IPC: A61B8/08 ,  A61B8/00 ,  G06T3/40 ,  G06T7/32 ,  G06T7/12

Abstract: A computer-implemented method for combining two 3-dimensional ultrasound images of a patient's body part containing blood vessels into a single 3-dimensional ultrasound image of that body part with a greater field of view. Blood vessels within the body part are used for registration. The two ultrasound images are preprocessed using a vessel enhancement algorithm to derive two corresponding enhanced images. The enhanced images can undergo a registration process based upon minimizing a mean-square-difference metric to derive an enhanced rigid transform, which represents a transform that maps the first enhanced image onto the second enhanced image. The two enhanced images are seamlessly combined via a blending process (via the use of a distance transform based weighting of the voxel values) to derive an output image.

公开(公告)号：US10392646B2

公开(公告)日：2019-08-27

申请号：US14436844

申请日：2013-10-17

Applicant: UNIVERSITY OF MARYLAND, OFFICE OF TECHNOLOGY COMMERCIALIZATION ,  CHILDREN'S NATIONAL MEDICAL CENTER ,  THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human

Inventor： Omar Bilal Ayyub ,  Adam Michael Behrens ,  Peter Kofinas ,  Marshall Lynn Summar ,  Juan Manuel Cabrera-Luque ,  Gary Cunningham ,  Anton Simeonov ,  Juan Marugan

IPC: G01N33/68 ,  C12N9/02 ,  C12N9/06 ,  C12Q1/00 ,  C12N11/04 ,  C12N11/10 ,  G01N27/327

Abstract: The present invention relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reagentless system comprising an electrode modified by hydrogel that comprises at least one enzyme that oxidizes at least one substrate that is at least one amino acid. In some embodiments, the biosensor comprises a hydrogel comprising alginate. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the hydrogel.

公开(公告)号：US20180291928A1

公开(公告)日：2018-10-11

申请号：US15696230

申请日：2017-09-06

Applicant: Technology Commercialization Corp.

Inventor： Michael W. Kenworthy ,  Boris Ganelin

IPC: F04D29/66 ,  F04D29/44

Abstract: An improved rotary machine of the invention may include a rotor with an impeller mounted thereon. A side cavity may be formed between an impeller and the housing. The rotary machine may be further equipped with an annular subdividing disk for segmenting a fluid flow in the cavity into a first fluid flow between the disc and the impeller, and a second fluid flow on the other side of the disk between the disc and the housing. The rotary machine of the invention also features a peripheral annular space formed in the periphery of the housing in the cavity at a location adjacent to a peripheral region of the annular subdividing disk. Importantly, this peripheral annular space is void of restrictions to circumferential fluid flow therein so as to alter the second fluid flow in the cavity in order to reduce pressure variations and flow disturbances along the circumference of the rotary machine. This in turn improves rotational balance of the rotary machine.

公开(公告)号：US10066782B2

公开(公告)日：2018-09-04

申请号：US15543448

申请日：2015-01-14

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION (CIMTEC) ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： Jeffrey Bax ,  Dandan Shan ,  Christopher Waring ,  Aaron Fenster

IPC: F16M13/02 ,  F16M11/38 ,  F16M11/10 ,  F16M11/20 ,  F16M11/42

Abstract: A counterbalance apparatus for supporting a load includes a base, a load bearing arm, a toggle linkage, and first and second resilient members for applying a force to the load bearing arm. The load bearing arm has pivot points forming a parallelogram linkage, and is adapted to support the load at a distal end. The toggle linkage can include an adjustment member positioned to define a distance relative to the attachment point. The first resilient member is adapted to apply a force to the load bearing arm and may have a first end connected to a first portion of the parallelogram linkage and a second end connected to the adjustment member. Movement of the toggle linkage to the load bearing position engages the forces of the resilient members and movement of the adjustment member varies the distance to adjust a support vector adapted to counterbalance the load vector.

公开(公告)号：US20180023758A1

公开(公告)日：2018-01-25

申请号：US15543448

申请日：2015-01-14

Applicant: Centre for Imaging Technology Commercialization (CIMTEC) ,  THE UNIVERSITY OF WESTERN ONTARIO

Inventor： Jeffrey BAX ,  Dandan SHAN ,  Christopher WARING ,  Aaron FENSTER

IPC: F16M13/02 ,  F16M11/10 ,  F16M11/20 ,  F16M11/38

CPC classification number: F16M13/02 ,  B66C23/76 ,  F16M11/046 ,  F16M11/048 ,  F16M11/10 ,  F16M11/18 ,  F16M11/2092 ,  F16M11/38 ,  F16M11/42 ,  F16M2200/047 ,  F16M2200/048 ,  F16M2200/061

Abstract: A counterbalance apparatus for supporting a load includes a base, a load bearing arm, a toggle linkage, and first and second resilient members for applying a force to the load bearing arm. The load bearing arm has pivot points forming a parallelogram linkage, and is adapted to support the load at a distal end. The toggle linkage can include an adjustment member positioned to define a distance relative to the attachment point. The first resilient member is adapted to apply a force to the load bearing arm and may have a first end connected to a first portion of the parallelogram linkage and a second end connected to the adjustment member. Movement of the toggle linkage to the load bearing position engages the forces of the resilient members and movement of the adjustment member varies the distance to adjust a support vector adapted to counterbalance the load vector.

公开(公告)号：US09726517B2

公开(公告)日：2017-08-08

申请号：US14414541

申请日：2013-07-15

Applicant: University of Western Ontario ,  Centre for Imaging Technology Commercialization

Inventor： Jeffrey Bax ,  Aaron Fenster

IPC: G01B7/30 ,  G01R33/02 ,  G01D5/14 ,  G01B5/004 ,  A61B6/03 ,  A61B8/08 ,  A61B8/00 ,  A61B5/055 ,  G01D5/26 ,  A61B34/20 ,  A61B90/11 ,  A61B34/30 ,  A61B90/00

CPC classification number: G01D5/14 ,  A61B5/055 ,  A61B6/032 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/0858 ,  A61B8/4218 ,  A61B8/4263 ,  A61B8/466 ,  A61B8/483 ,  A61B34/20 ,  A61B34/30 ,  A61B90/11 ,  A61B2034/2059 ,  A61B2090/378 ,  G01B5/004 ,  G01D5/26

Abstract: A mechanical tracking system comprises a first set of linkage arms, a second set of linkage arms, a pair of shafts connected at a first end to one arm of the first set of linkage arms and at a second end to one arm of said second set of the linkage arms, wherein each arm of the second set of linkage arms is oriented out of phase with a respective arm of the first set of linkage arms, an attachment shaft positioned adjacent to the first set of linkage arms to accommodate a tool, and a sensor arrangement configured to sense the orientation and position of the attachment shaft.

公开(公告)号：US09655679B2

公开(公告)日：2017-05-23

申请号：US13875204

申请日：2013-05-01

Applicant: UNIVERSITY OF MARYLAND, OFFICE OF TECHNOLOGY COMMERCIALIZATION

Inventor： Jaydev P. Desai ,  Elif Ayvali

IPC: A61B1/00 ,  A61B19/00 ,  A61B17/34 ,  A61B90/11 ,  A61B1/04 ,  A61B17/00 ,  A61B90/00 ,  A61B34/20

CPC classification number: A61B90/11 ,  A61B17/3417 ,  A61B17/3421 ,  A61B90/39 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2034/2055 ,  A61B2090/3735

Abstract: A steerable probe having high-power-density actuators positioned at joints along the length of the probe. The actuators are moveable about and between a straight position and a curved position in response to selective actuation.