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    Real-time PCR point mutation assays for detecting HIV-1 resistance to antiviral drugs
    93.
    发明专利
    Real-time PCR point mutation assays for detecting HIV-1 resistance to antiviral drugs 未知

    公开(公告)号：AU2014273917A1

    公开(公告)日：2015-12-17

    申请号：AU2014273917

    申请日：2014-06-02

    Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

    Inventor： JOHNSON JEFFREY A ,  HENEINE WALID M ,  LIPSCOMB JONATHAN T ,  WEI XIERONG

    IPC: C12Q1/70

    Abstract: Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase, protease, or integrase of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID NOS: 1-89, 96-122, and 124-151. Also provided are the oligonucleotides consisting of the nucleotides as set forth in SEQ ID NOS: 1-89, 96-122, and 124-151. Each of the disclosed oligonucleotides is a probe or a primer. Also provided are mixtures of primers and probes and for use in RT-PCR and primary PCR reactions disclosed herein. Provided are methods for the specific detection of several mutations in HIV simultaneously or sequentially. Mutations in the reverse transcriptase, protease, or integrase of HIV can be detected using the methods described herein.

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