公开(公告)号：US11642374B2

公开(公告)日：2023-05-09

申请号：US16182146

申请日：2018-11-06

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  INTIMA BIOSCIENCE, INC. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

Inventor： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC: A61P35/00 ,  A61K35/17 ,  A61K48/00 ,  C07K14/715 ,  C12N15/113 ,  C07K14/47 ,  C07K14/725 ,  C12N5/0783 ,  C07K14/705 ,  C12N15/90 ,  C12N9/22 ,  C12N9/96 ,  C12N15/87

CPC classification number: A61K35/17 ,  C07K14/4718 ,  C07K14/7051 ,  C07K14/70503 ,  C07K14/7158 ,  C12N5/0636 ,  C12N9/22 ,  C12N9/96 ,  C12N15/113 ,  C12N15/907 ,  C12N15/87 ,  C12N2310/20 ,  C12N2510/00

Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

公开(公告)号：US20220105133A1

公开(公告)日：2022-04-07

申请号：US17481404

申请日：2021-09-22

Applicant: Regents of the University of Minnesota ,  Intima Bioscience, Inc. ,  The U.S.A., as Represented by the Secretary, Department of Health and Human Service

Inventor： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC: A61K35/17 ,  C12N15/113 ,  C07K14/705 ,  C07K14/47 ,  A61P31/00 ,  A61P35/00 ,  A61K9/00 ,  C07K14/725 ,  C07K14/715 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/79 ,  C12N15/90

Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.

公开(公告)号：US20210024924A1

公开(公告)日：2021-01-28

申请号：US16809343

申请日：2020-03-04

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  Intima Bioscience, Inc.

Inventor： Lei S. Qi ,  Modassir S. Choudhry ,  Xueqiu Lin ,  Xiaoshu Xu

IPC: C12N15/113

Abstract: Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.

公开(公告)号：WO2018081470A1

公开(公告)日：2018-05-03

申请号：PCT/US2017/058605

申请日：2017-10-26

Applicant: INTIMA BIOSCIENCE, INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： HENLEY, Thomas ,  RHODES, Eric ,  CHOUDHRY, Modassir ,  MORIARITY, Branden ,  WEBBER, Beau

IPC: A61K35/12 ,  A61K48/00 ,  C12N15/64 ,  C12N15/86 ,  C12N15/90

Abstract: The present disclosure provides methods of producing a population of genetically modified cells using viral or non-viral vectors. Also disclosed are modified viruses for producing a population of genetically modified cells and/or for the treatment of cancer.

Abstract translation: 本公开提供了使用病毒或非病毒载体产生遗传修饰细胞群体的方法。 还公开了用于产生遗传修饰细胞群和/或用于治疗癌症的修饰病毒。

公开(公告)号：WO2019006418A3

公开(公告)日：2019-01-03

申请号：PCT/US2018/040480

申请日：2018-06-29

Applicant: INTIMA BIOSCIENCE, INC.

Inventor： HENLEY, Thomas ,  AGBANDJE-MCKENNA, Mavis ,  BUERCKSTUEMMER, Tilmann ,  VINEY, Lydia ,  CHOUDHRY, Modassir

IPC: A61K35/17 ,  C12N5/0783 ,  C12N15/63 ,  C12N15/74 ,  C12N15/113 ,  C12N15/861 ,  C12N15/864 ,  C07H21/04

Abstract: Genetically modified compositions, such as adeno-associated viral vectors and primary cells, for treating various conditions and diseases. Disclosed are also modified adeno-associated viruses for the treatment of cancer. Also disclosed are the methods of making and using the genetically modified compositions in treating various diseases, conditions, and cancer.

公开(公告)号：WO2017023801A1

公开(公告)日：2017-02-09

申请号：PCT/US2016/044856

申请日：2016-07-29

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  INTIMA BIOSCIENCE, INC.

Inventor： MORIARITY, Branden ,  WEBBER, Beau ,  MCIVOR, R., Scott ,  CHOUDHRY, Modassir

IPC: A61K35/17 ,  C12N1/15 ,  C12N15/09 ,  C12N15/85 ,  C12Q1/68

CPC classification number: A61K35/17 ,  C07K14/4718 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/7158 ,  C12N5/0636 ,  C12N9/22 ,  C12N9/96 ,  C12N15/113 ,  C12N15/87 ,  C12N15/907 ,  C12N2310/20 ,  C12N2510/00 ,  C12N2800/80 ,  Y02A50/463

Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

Abstract translation: 公开了用于治疗癌症的转基因组合物，例如非病毒载体和T细胞。 还公开了制备和使用转基因组合物治疗癌症的方法。

公开(公告)号：GB2573406B

公开(公告)日：2021-11-10

申请号：GB201906855

申请日：2017-10-18

Applicant: UNIV MINNESOTA ,  INTIMA BIOSCIENCE INC ,  US HEALTH

Inventor： BRANDEN MORIARITY ,  BEAU WEBBER ,  MODASSIR CHOUDHRY ,  STEVEN A ROSENBERG ,  DOUGLAS C PALMER ,  NICHOLAS P RESTIFO

IPC: C12N15/11 ,  A61K35/17 ,  C12N5/0783 ,  C12N9/10

Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.

公开(公告)号：GB2573406A

公开(公告)日：2019-11-06

申请号：GB201906855

申请日：2017-10-18

Applicant: UNIV MINNESOTA ,  INTIMA BIOSCIENCE INC ,  THE US SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER

Inventor： BRANDEN MORIARITY ,  BEAU WEBBER ,  MODASSIR CHOUDHRY ,  STEVEN A ROSENBERG ,  DOUGLAS C PALMER ,  NICHOLAS P RESTIFO

IPC: C12N15/11 ,  A61K35/17 ,  C12N5/0783 ,  C12N9/10

Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.

公开(公告)号：AU2017347848A1

公开(公告)日：2019-05-23

申请号：AU2017347848

申请日：2017-10-26

Applicant: INTIMA BIOSCIENCE INC ,  UNIV MINNESOTA

Inventor： HENLEY THOMAS ,  RHODES ERIC ,  CHOUDHRY MODASSIR ,  MORIARITY BRANDEN ,  WEBBER BEAU

IPC: A61K35/12 ,  A61K48/00 ,  C12N15/64 ,  C12N15/86 ,  C12N15/90

Abstract: The present disclosure provides methods of producing a population of genetically modified cells using viral or non-viral vectors. Also disclosed are modified viruses for producing a population of genetically modified cells and/or for the treatment of cancer.

公开(公告)号：US11925664B2

公开(公告)日：2024-03-12

申请号：US16900368

申请日：2020-06-12

Applicant: Regents of the University of Minnesota ,  Intima Bioscience, Inc. ,  The U.S.A., as Represented by the Secretary, Department of Health and Human Services

Inventor： Branden Moriarity ,  Beau Webber ,  David Largaespada ,  Modassir Choudhry ,  Steven A. Rosenberg

IPC: A61K48/00 ,  A61K35/17 ,  C07K14/47 ,  C07K14/705 ,  C07K14/715 ,  C07K14/725 ,  C12N5/0783 ,  C12N9/22 ,  C12N9/96 ,  C12N15/07 ,  C12N15/113 ,  C12N15/90 ,  C12N15/87

CPC classification number: A61K35/17 ,  C07K14/4718 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/7158 ,  C12N5/0636 ,  C12N9/22 ,  C12N9/96 ,  C12N15/113 ,  C12N15/907 ,  C12N15/87 ,  C12N2310/20 ,  C12N2510/00

Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.