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公开(公告)号：KR1020080036411A
公开(公告)日：2008-04-28
申请号：KR1020060102962
申请日：2006-10-23
Applicant: (주)아모레퍼시픽
Abstract: A composition comprising gallocatechin gallate(GCG) is provided to increase expression of cholesterol 7alpha-hydroxylase and expression of a low density lipoprotein receptor(LDLR) and show better binding increase efficacy between a low density lipoprotein(LDL) and the LDLR than that of epigallocatechin gallate(EGCG), thereby showing excellent hyperlipidemia improving effect. A composition for improving hyperlipidemia comprises GCG as an effective ingredient, active ingredient, wherein the GCG is derived from green tea. A food or a pharmaceutical formulation comprises the composition for improving hyperlipidemia. Further, the composition for improving hyperlipidemia reduces a number of tyighlycerides in blood and increases a high density lipoprotein.
Abstract translation: 提供包含没食子儿茶素没食子酸酯（GCG）的组合物以增加胆固醇7α-羟化酶的表达和低密度脂蛋白受体（LDLR）的表达，并且在低密度脂蛋白（LDL）和LDLR之间显示出比表没食子儿茶素更好的结合增加功效 没食子酸酯（EGCG），从而显示优异的高脂血症改善作用。 用于改善高脂血症的组合物包括GCG作为有效成分，活性成分，其中GCG来自绿茶。 食品或药物制剂包含用于改善高脂血症的组合物。 此外，用于改善高脂血症的组合物可减少血液中的多种甘油三酸酯并增加高密度脂蛋白。
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公开(公告)号：KR1020070095709A
公开(公告)日：2007-10-01
申请号：KR1020060026238
申请日：2006-03-22
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/498 , A61K8/97 , A61K2800/782 , A61Q19/00
Abstract: A cosmetic composition is provided to inhibit the amount of sebum produced from sebocytes by inhibiting the formation and activity of SREBP-1(Sterol Regulatory Element Binding Protein-1), thereby capable of effectively improving sebum metabolism and acne. A cosmetic composition comprises 0.001-30 wt.% of at least one selected from the group consisting of catechin such as epigallocatechin gallate(EGCG), gallocatechin gallate(GCG) and a mixture thereof and flavonols such as quercetin, kaempferol and myricetin as effective ingredients and is characterized in that it inhibit the formation and activity of SREBP-1 which is a transcription factor.
Abstract translation: 提供化妆品组合物，通过抑制SREBP-1（甾醇调节元件结合蛋白-1）的形成和活性来抑制由皮脂细胞产生的皮脂的量，从而能够有效地改善皮脂代谢和痤疮。 化妆品组合物包含0.001-30重量％的选自儿茶素如表没食子儿茶素没食子酸酯（EGCG），没食子儿茶素没食子儿茶素（GCG）及其混合物中的至少一种，和黄酮醇如槲皮素，山奈酚和杨梅素作为有效成分 其特征在于它抑制作为转录因子的SREBP-1的形成和活性。
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公开(公告)号：KR1020070091964A
公开(公告)日：2007-09-12
申请号：KR1020060021797
申请日：2006-03-08
Applicant: (주)아모레퍼시픽
Abstract: A skin external composition is provided to inhibit TNF-alpha(Tumor Necrosis Factor-alpha) and the expression of MMP-1 through activation of PPAR-alpha(Peroxisome Proliferator Activated Receptor-alpha), thereby inhibiting skin aging. A skin external composition comprises 0.001-10 wt.% of at least one kind selected from the group consisting of epigallocatechin(EGCG), gallocatechingallate(GCG), epicatechin gallate(ECG), catechin gallate(CG), catechin(C), gallic acid, quercetin, kaempferol, theobromine, theophylline, theanine, quinic acid, an ethanol extract of green tea leaves, an aqueous extract of green tea leaves, an extract of catechin 1 including 70% of catechin and an extract of catechin 2 including 50% of EGCG as an effective ingredient.
Abstract translation: 提供皮肤外用组合物以通过激活PPAR-α（过氧化物酶体增殖剂活化受体-α）抑制TNF-α（肿瘤坏死因子-α）和MMP-1的表达，从而抑制皮肤老化。 皮肤外用组合物包含0.001-10重量％的选自下组的至少一种：表没食子儿茶素（EGCG），gallocatechingallate（GCG），表儿茶素没食子酸酯（ECG），儿茶素没食子酸酯（CG），儿茶素（C） 酸，槲皮素，山奈酚，可可碱，茶碱，茶氨酸，奎尼酸，绿茶叶的乙醇提取物，绿茶叶的水提物，儿茶素1的提取物，其中儿茶素含量为70％，儿茶素2提取物含50％ 的EGCG作为有效成分。
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公开(公告)号：KR1020070028901A
公开(公告)日：2007-03-13
申请号：KR1020050083665
申请日：2005-09-08
Applicant: (주)아모레퍼시픽
Abstract: A skin external composition comprising optimal concentration of catechins and theanine is provided to increase biosynthesis of collagen in the inner skin, restore elasticity of the skin, and improve wrinkles in the skin by containing low concentration of catechins and theanine at a fixed ingredient rate. The skin external composition for promoting biosynthesis of collagen and improving skin aging and elasticity comprises 0.0004-0.025 wt.% of catechins and 0.008-2.5 wt.% of theanine based on the total weight of the composition, wherein the weight ratio of catechins to theanine is 1:20 to 1:100, and the catechin is EGCG(epigallocatechin gallate), GCG(gallocatechin gallate), ECG(epicatechin gallate) or CG(catechin gallate).
Abstract translation: 提供包含最佳浓度的儿茶素和茶氨酸的皮肤外用组合物以增加内皮中胶原的生物合成，恢复皮肤的弹性，并通过以固定的成分速率含有低浓度的儿茶素和茶氨酸来改善皮肤的皱纹。 用于促进胶原蛋白的生物合成和改善皮肤老化和弹性的皮肤外用组合物包含基于组合物总重量的0.0004-0.025重量％的儿茶素和0.008-2.5重量％的茶氨酸，其中儿茶素与茶氨酸的重量比 是1:20至1:100，儿茶素是EGCG（表没食子儿茶素没食子酸酯），GCG（没食子儿茶素没食子酸酯），ECG（表儿茶素没食子酸酯）或CG（儿茶素没食子酸酯）。
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95.发明公开
公开(公告)号：KR1020040058851A
公开(公告)日：2004-07-05
申请号：KR1020020085364
申请日：2002-12-27
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: Provided is a composition for inhibiting phagocytosis containing Saururus Chinesis(Lour) Bail extract that effectively inhibits the phagocytosis of the keratinocyte activated by exposure to ultraviolet rays. Further, provided is a pharmaceutical composition which prevents and treats various kinds of diseases associated with phagocytosis. CONSTITUTION: A phagocytosis inhibiting composition is characterized by containing, as an active ingredient, Saururus Chinesis(Lour) Bail extract in the amount of 0.0001-10 wt.%. It is used for prevention and treatment of phagocytosis related diseases.
Abstract translation: 目的：提供一种用于抑制吞噬作用的组合物，其含有SaururusChinesis（Lour）保释提取物，其有效抑制通过暴露于紫外线而活化的角质形成细胞的吞噬作用。 此外，提供了防止和治疗与吞噬作用相关的各种疾病的药物组合物。 构成：吞噬抑制组合物的特征在于以0.0001-10重量％的量含有SaururusChinesis（Lour）保释提取物作为活性成分。 用于预防和治疗吞噬相关疾病。
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Patent Agency Ranking
公开(公告)号：KR101706153B1
公开(公告)日：2017-02-14
申请号：KR1020150108902
申请日：2015-07-31
Applicant: 한국과학기술원
Abstract: 본발명에따른미세유체칩기반세포배양시스템은내부공간에미세유체칩이장착되는본체; 및상기본체의내부공간에상기미세유체칩이탈부착가능하도록구비되는장착판;을포함하며, 상기본체는상기내부공간의온도및 습도중 적어도하나이상을일정한범위내로유지시키는제어부를포함할수 있다.
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公开(公告)号：KR101370931B1
公开(公告)日：2014-03-19
申请号：KR1020120043946
申请日：2012-04-26
Applicant: 한국과학기술원
Abstract: 본 발명은 세포가 받고 있는 전단응력과 전기장을 독립적으로 제어하면서 다양한 외부 자극에 의한 세포의 반응을 실시간으로 관찰할 수 있는 미세유체 세포배양장치에 관한 것으로, 본 발명에 따르면, 균일한 전단응력을 가하기 위해 채널의 높이가 낮고 폭이 넓은 형태의 직사각형 단면을 가지는 세포 배양부, 상기 세포 배양부의 양단에 삽입되는 한천 염다리부(agar salt bridge), 실리콘 계열의 고분자 화합물로 덮은 후 경화시켜 유동액의 누수가 없도록 구성되어 채널 내부의 바닥에 삽입되는 전압 프로브(voltage probe)를 포함하고, 상기 실리콘 계열의 고분자 화합물이 전압 프로브의 피복의 역할과 동시에 세포가 자라는 기질(substrate)의 역할을 하며, 실리콘을 형성하는 조건을 변경하여 재질의 강성(rigidity)을 조절함으로써 세포가 자라는 생체 내 환경 � ��는 질병 상태를 모사할 수 있도록 구성된 전단응력과 전기장 및 바닥의 강성조절이 가능한 미세유체 세포배양장치가 제공된다.
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公开(公告)号：KR1020130120792A
公开(公告)日：2013-11-05
申请号：KR1020120043946
申请日：2012-04-26
Applicant: 한국과학기술원
Abstract: The present invention relates to a microfluidic cell culture device capable of observing a reaction of cells caused by various external stimulations on a real time basis while independently controlling shearing stress and a magnetic field actuated on the cells. According to the present invention, the microfluidic cell culture device includes a cell culture unit having a rectangular cross section of a shape which the height of a channel is low and the width thereof is wide for applying uniform shearing stress; an agar salt bridge unit which are inserted into both end portions of the cell culture unit; and a voltage probe which is coated with a polymer compound of a silicon group and hardened to prevent a leakage of fluid and which is inserted into the inner bottom surface of the channel. The polymer compound of a silicon group functions as cladding for the voltage probe and a substrate on which the cells are cultured at the same time. The present invention provides the microfluidic cell culture device capable of controlling shearing stress, the magnetic field, and the rigidity of the substrate which enables an environment of a body where the cells are cultured by controlling the rigidity of a material or disease by changing conditions for forming silicon.
Abstract translation: 本发明涉及一种微流体细胞培养装置，能够在独立地控制剪切应力和在细胞上致动的磁场的同时，实时地观察由各种外部刺激引起的细胞的反应。 根据本发明，微流体细胞培养装置包括细胞培养单元，其具有矩形横截面，其通道高度低，宽度宽，用于施加均匀的剪切应力; 插入细胞培养单元的两端部的琼脂盐桥单元; 以及涂覆有硅基团的高分子化合物并被硬化以防止流体泄漏并被插入到通道的内底表面中的电压探针。 硅基团的高分子化合物用作电压探针的包层以及同时培养细胞的底物。 本发明提供了能够控制剪切应力，磁场和基质的刚性的微流体细胞培养装置，其能够通过控制材料或疾病的刚性来控制细胞被培养的身体的环境， 形成硅。
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公开(公告)号：KR1020170014890A
公开(公告)日：2017-02-08
申请号：KR1020150108902
申请日：2015-07-31
Applicant: 한국과학기술원
Abstract: 본발명에따른미세유체칩기반세포배양시스템은내부공간에미세유체칩이장착되는본체; 및상기본체의내부공간에상기미세유체칩이탈부착가능하도록구비되는장착판;을포함하며, 상기본체는상기내부공간의온도및 습도중 적어도하나이상을일정한범위내로유지시키는제어부를포함할수 있다.
Abstract translation: 根据本发明的基于微流体芯片的细胞培养系统包括：其中微流体芯片安装在内部空间中的主体; 和设置，以允许在所述主体的内部空间中的微流体芯片可拆卸的安装板;其中，所述主体可以是控制单元保持在内部空间的温度和湿度中的至少一个的范围内。
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公开(公告)号：KR101433091B1
公开(公告)日：2014-08-25
申请号：KR1020120043952
申请日：2012-04-26
Applicant: 한국과학기술원
Abstract: 박테리아의 주화성 분석용 마이크로 플루이딕 장치, 제조방법 및 이를 이용한 박테리아의 주화성 분석 방법을 개시한다. 상기 박테리아의 주화성 분석용 마이크로 플루이딕 장치는 외부로부터 제공되는 유리 하부기판; 상기 유리 하부기판 상에 접하되도록 형성되는 PDMS 상부 기판;을 포함하며, 상부 기판은, 다종의 세포를 배양시키는 적어도 하나 이상의 세포 배양 챔버; 상기 PDMS 상부 기판 내에 형성되며, 외부로부터 제공되는 박테리아를 상기 상부 기판 내에 주입시키도록 형성된 박테리아 주입구; 외부로부터 제공되는 콜라겐 젤이 주입되는 적어도 한 개 이상의 콜라겐 젤 주입구;를 포함하며, 상기 PDMS 상부 기판은, 상기 세포 배양 챔버, 박테리아 주입 채널 입구, 박테리아 추출 채널 출구 및 콜라겐 젤 주입구가 연결시키는 미세 유로들가 형성되는 것을 특징으로 한다.
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