公开(公告)号：WO1998032860A1

公开(公告)日：1998-07-30

申请号：PCT/US1997023685

申请日：1997-12-19

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  DAI, Yifan

IPC: C12N15/33

CPC classification number: C12N15/86 ,  C12N2710/10343

Abstract: The invention provides reagents and methods for highly efficient generation of adenoviral vectors by homologous recombination. The present invention provides unique shuttle vectors and an improved methodology for co-transfection of a shuttle vector and a helper plasmid into 293 cells to generate E1-deleted, E1 / E3-deleted, E1 / E2a / E3-deleted or E1 / E3 / E4 / protein IX-deleted adenoviral vectors.

Abstract translation: 本发明提供了通过同源重组高效产生腺病毒载体的试剂和方法。 本发明提供独特的穿梭载体和用于将穿梭载体和辅助质粒共转染293细胞以产生E1缺失的E1 / E3缺失的E1 / E2a / E3缺失或E1 / E3 / E4 /蛋白IX缺失的腺病毒载体。

公开(公告)号：WO1998024501A1

公开(公告)日：1998-06-11

申请号：PCT/US1997021253

申请日：1997-11-21

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MOONEY, Charles ,  PECOR, Robert ,  BOBO, Donald, E., Jr. ,  HIGGINGS, Michael, J.

IPC: A61M25/00

CPC classification number: A61B17/3417 ,  A61B17/3498 ,  A61B2017/3445 ,  A61B2017/3466 ,  A61M25/0023 ,  A61M25/0032 ,  A61M25/0075 ,  A61M25/0668 ,  A61M2025/0034 ,  A61M2025/0035 ,  A61M2025/0036

Abstract: A multiple lumen access device for use in providing a single entry port into the human body for selectively introducing medical implements therethrough and for providing simultaneous auxiliary access into the body. The multiple lumen access device (10, 400, 500, 520, 550) includes a multiple lumen sheath (404, 506, 530) which may have an outer tube (12, 422) and structure defining a device lumen (30, 31, 130, 230, 330, 426, 574, 582, 586) located therein. The inner structure may be an inner tube (24, 124, 224, 324, 432). The outer tube and inner structure are located so as to define at least one auxiliary lumen (36, 37, 48, 49, 138, 140, 142, 236, 248, 336, 428, 584, 588) which may be located between the exterior surface of the inner tube and the interior surface of the outer tube. Embodiments include flexible inner tubes which can be flexed between relaxed and expanded/contracted positions wherein the relative cross-sectional areas of the device lumen and auxiliary lumens are varied. The access device further includes a valve (70, 418, 502, 514, 528, 532, 554) which provides sealing of the device lumen. The valve may be provided in a lumen junction housing (56, 402), or separate from the housing either permanently or removably connected with the device lumen. Alternatively, a multiple lumen sheath (560) may be passed through a valve (554) leading to a conventional introducer (564). The valve may also be molded separately as a rigid insert (418) and retained in a cavity (450) formed in a flexible junction housing.

Abstract translation: 一种用于向人体提供单个进入口用于选择性地引入医疗器械的多流体存取装置，用于提供同时进入身体的辅助通道。 多管腔进入装置（10,400,500,500,550,550）包括多腔护套（404,506,530），其可具有外管（12,422）和限定器件内腔（30,31,52）的结构， 130，230，330，426，574，582，586）。 内部结构可以是内管（24,124,224,324,432）。 外管和内部结构被定位成限定至少一个辅助内腔（36,37,48,49,138,140,​​142,236,248,336,428,584,558），其可位于 内管的外表面和外管的内表面。 实施例包括柔性内管，其可以在松弛和膨胀/收缩位置之间弯曲，其中装置内腔和辅助流明的相对横截面面积是变化的。 进入装置还包括提供装置内腔密封的阀（70,418,502,514,528,532,554）。 阀可以设置在管腔接合壳体（56,402）中，或者与壳体永久地或可拆卸地与装置内腔连接。 或者，多腔护套（560）可以通过通向常规导引器（564）的阀（554）。 阀也可以作为刚性插入件（418）分开模制，并且保持在形成在柔性连接壳体中的空腔（450）中。

公开(公告)号：WO1998022150A1

公开(公告)日：1998-05-28

申请号：PCT/US1997018854

申请日：1997-10-23

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  CHAPMAN, John, R. ,  STARK, Peter, R., H. ,  REED, Michael, A. ,  LARSON, Dale, N. ,  CUFFARO, Daniel, F.

IPC: A61L02/08

CPC classification number: A61M1/3681 ,  A61L2/0011 ,  A61M1/3683

Abstract: Apparatus and methods for treating a biological fluid with light and for inactivating contaminants in biological fluid. The biological fluid is contacted with a light source (24) providing a high intensity light to the biological fluid. The biological fluid may include a quantity of a photochemical agent that, when activated by light, is operable to cause inactivation of at least some of the contaminants. The apparatus includes a light box (10), including a retractable shutter assembly (26) that encloses the light source (24). The shutter assembly (26) includes a cylindrical tube (41) that, when raised, shields the light source (24). In addition, cylindrical tube (28), attached to platform (36) of base assembly (22), encloses the light source (24) and the shutter assembly (26).

Abstract translation: 用于用光处理生物流体并灭活生物流体中的污染物的装置和方法。 生物流体与向生物流体提供高强度光的光源（24）接触。 生物流体可以包括一定数量的光化学试剂，当光被活化时，其可操作地使至少一些污染物失活。 该装置包括一个灯箱（10），其包括封闭光源（24）的可缩回的挡板组件（26）。 闸门组件（26）包括一个圆柱形管（41），其在升起时屏蔽光源（24）。 此外，附接到基座组件（22）的平台（36）的圆柱形管（28）封闭光源（24）和快门组件（26）。

公开(公告)号：WO1998018908A1

公开(公告)日：1998-05-07

申请号：PCT/US1997017984

申请日：1997-10-03

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  HERMAN, Robert, E. ,  CHAPMAN, John ,  CHONG-SON, Sun ,  MATHIAS, Jean, M. ,  MAYAUDON, Véronique ,  DE GHELDERE, Serge ,  BISCHOF, Daniel, F.

IPC: C12N07/04

CPC classification number: A61L2/0011 ,  A61K35/16 ,  A61L2/022 ,  A61L2/08 ,  Y10S435/975

Abstract: Systems and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.

Abstract translation: 系统和方法处理能够携带污染物的携带血浆的污染物和细胞物质。 系统和方法通过过滤将细胞物质与血浆分离，从而去除携带在细胞内的污染物。 该系统和方法将等离子体添加到光敏材料中。 系统和方法将所选波长的辐射发射到等离子体中以激活光活性物质，从而根除细胞物质不会夹带的污染物。

公开(公告)号：WO1998018467A1

公开(公告)日：1998-05-07

申请号：PCT/US1997018722

申请日：1997-10-21

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BERGSTRÖM, Jonas

IPC: A61K31/415

CPC classification number: A61K31/4172 ,  A61K33/14 ,  A61K2300/00

Abstract: Methods and compositions for treating renal failure patients are provided. Pursuant to the present invention, a renal failure patient is provided with an intravenous or dialysis solution that includes a therapeutically effective amount of L-carnosine. In part, the L-carnosine will prevent the renal failure patient from developing L-carnosine deficiency.

Abstract translation: 提供了治疗肾衰竭患者的方法和组合物。 根据本发明，向肾衰竭患者提供包含治疗有效量的L-肌肽的静脉内或透析溶液。 部分地，L-肌肽会阻止肾衰竭患者发生L-肌肽缺乏症。

公开(公告)号：WO1997039247A1

公开(公告)日：1997-10-23

申请号：PCT/US1997002738

申请日：1997-02-24

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  DANBY, Hal.

IPC: F16B02/06

CPC classification number: F16B2/065 ,  A61M5/1415 ,  G05G1/10

Abstract: A clamp for a medical device such as an infusion pump has a plurality of orientations adapted to grip either substantially vertical or horizontal gripped members (16) and has an actuation knob (66) with extensible arms (70, 72) wherein the arms are operative to provide greater available torque to remove the clamp than is available to apply the clamp.

Abstract translation: 用于诸如输液泵的医疗装置的夹具具有适于夹紧基本上垂直或水平的夹持构件（16）的多个取向并且具有带有可伸臂（70,72）的致动旋钮（66），其中臂可操作 以提供比可用于施加夹具更大的可用扭矩以移除夹具。

公开(公告)号：WO1997037703A1

公开(公告)日：1997-10-16

申请号：PCT/US1997004708

申请日：1997-03-21

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  ALLEN, Tim ,  BRUNDLE, Alan ,  DANDBY, Hal ,  HARRIS, Mark ,  HUTCHINS, Geoff ,  LaBEDZ, Ralph, H. ,  LYNN, Kenneth, M. ,  McGRAGHAN, Thomas ,  MONAGHAM, Martin ,  MORASKI, Kevin, J. ,  MYREN, Svante, Eric ,  PAGE, Stuart ,  PLUMB, Jon ,  STEWART, Janice ,  TURNER, John, M.

IPC: A61M05/142

CPC classification number: F04B53/16 ,  A61M5/142 ,  A61M5/16854 ,  A61M5/365 ,  A61M39/281 ,  A61M2205/14 ,  F04B43/082 ,  F04B43/1223 ,  Y10S128/12 ,  Y10T29/49236

Abstract: A medical infusion pump is disclosed which provides for greatly improved accuracy in the delivery of medicaments to a patient. Among the various features included in the instant invention is a pumping body which serves to deform and reform a tube so as to maintain the initial cross section thereof and thereby preserve the output accuracy of the pump. Also disclosed with regard to the pumping body is a wholly mechanical synchronization of the pumping body and valves associated therewith and coactive with the aforementioned synchronization a mechanical linearization of output of the pumping body per each pumping cycle. Additionally, several features which serve to enhance the utility of the instant invention are also included therein among which is an associated assembly operative to automatically load or disload a tube or IV set into or out of the pumping body. Associated with the assembly operative to automatically load or disload a tube and disclosed herein is an assembly operative to selectively open or close a slide clamp associated with the tube in such a way as to ensure that the tube is occluded such that in combination with the valves associated with the pumping body, a condition of free-flow of medicament is never realized. Additionally disclosed are sensor housings adapted to measure various quantities associated with fluid flowing through the tube wherein the housings are with associated components adapted to achieve a substantially normal orientation with respect to the sidewall of the tube and in the achieving of such normal orientation, expressing an essentially zero elastic stress gradient across the tube.

Abstract translation: 公开了一种医疗输液泵，其提供了向患者输送药物的大大提高的准确度。 在本发明中包括的各种特征之中的是泵体，其用于使管变形和重新变形以保持其初始横截面，从而保持泵的输出精度。 关于泵体还公开了泵体和与其相关联的阀的完全机械同步，并且与上述同步共同作用，每个泵送循环的泵送体的输出的机械线性化。 此外，还包括用于增强本发明的实用性的几个特征，其中相关联的组件可操作以自动加载或卸载进入或离开泵体的管或IV。 与可操作以自动加载或卸载管并且在此公开的组件相关联的组件是可操作以选择性地打开或关闭与管相关联的滑动夹具的组件，以确保管被封闭，使得与阀组合 与泵送体相关联，从未实现药物自由流动的状态。 另外公开的是适于测量与流过管的流体相关联的各种量的传感器壳体，其中壳体具有适于实现相对于管的侧壁的基本正常取向的相关部件，以及实现这种正常取向， 在管上基本上为零弹性应力梯度。

公开(公告)号：WO1997025003A1

公开(公告)日：1997-07-17

申请号：PCT/US1997000189

申请日：1997-01-02

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  LAM, Hung ,  DESERAN, Lisa ,  RHEE, Richard

IPC: A61F02/24

CPC classification number: A61F2/2496 ,  A61B5/1076 ,  A61B90/06 ,  A61F2/2427

Abstract: An aortic valve sizing obturator apparatus for employment in determining the correct size of an aortic annulus. The apparatus includes a cylindrical obturator body with a flange member formed thereabout. At least the under surface of the flange member is of a non-planar, multi-curvate configuration to thereby be complementary in shape to the annulus of an aortic valve when seated in the annulus during size determination. Within the cylindrical obturator body can be disposed a handle connector to which a handle can be attached during placement of the obturator apparatus within an annulus. The present invention also includes methodology for determining the size of an aortic valve annulus by employing a plurality of differently-sized aortic valve sizing obturators defined above and individually seating them sequentially within the aortic annulus until an obturator that reflects annulus size is located.

Abstract translation: 主动脉瓣尺寸闭塞器用于确定主动脉瓣的正确尺寸。 该装置包括圆柱形封闭体，其上形成有凸缘部件。 凸缘构件的至少下表面具有非平面的多弯曲构造，从而在尺寸确定期间坐在环形空间中时，形状与主动脉瓣的环形互补。 在圆柱形闭塞体内部可以设置手柄连接器，在将闭塞装置放置在环形空间内时可将手柄附接到手柄连接器。 本发明还包括通过采用多个不同尺寸的主动脉瓣尺寸闭塞器来确定主动脉瓣环的尺寸的方法，并且将它们依次单独地安置在主动脉瓣环内，直至反映环空尺寸的闭孔器。

公开(公告)号：WO1997012627A1

公开(公告)日：1997-04-10

申请号：PCT/US1996013512

申请日：1996-08-20

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BURHOP, Kenneth, E. ,  CHOW, Moses, S., S.

IPC: A61K38/16

CPC classification number: A61K38/42 ,  A61K2300/00

Abstract: Administration of stroma-free cross-linked hemoglobin during standard cardiac pulmonary resuscitation procedures enhances return of spontaneous circulation following electrical defibrillation. The difficulty in restoring spontaneous circulation directly correlates with a generally poor prognosis in cases of cardiac arrest. The therapeutic effect of hemoglobin as an adjunct to conventional treatment may thereby improve survival.

Abstract translation: 在标准心脏肺复苏手术期间给予基质无交联血红蛋白增强电除颤后自发循环的回报。 恢复自发循环的难度与心脏骤停病例的预后差异直接相关。 血红蛋白作为常规治疗辅助物的治疗效果可以提高存活率。

公开(公告)号：WO1997010831A1

公开(公告)日：1997-03-27

申请号：PCT/US1996013511

申请日：1996-08-20

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  AZARI, Mahmood, Rezazadeh ,  EBELING, August, A. ,  PICKEN, John, E. ,  ESTEP, Timothy, N.

IPC: A61K35/14

CPC classification number: C07K14/805 ,  A61K38/00

Abstract: During the purification of pharmaceutical grade cross-linked hemoglobin mixtures of cross-linked and uncross-linked hemoglobin are heated in the presence of nonstoichiometric amounts of oxygen, resulting in the selective precipitation of the uncross-linked hemoglobin. After separation of the precipitated uncross-linked tetramers, the cross-linked hemoglobin remaining in the supernatant is so purified that a further chromatography purification step is unnecessary. This hemoglobin is highly cross-linked, absolutely free of chromatography fines, and has a low methemoglobin content.

Abstract translation: 在药物级交联血红蛋白的纯化期间，在非化学计量的氧的存在下加热交联和未交联的血红蛋白的混合物，导致未交联的血红蛋白的选择性沉淀。 在沉淀的未交联的四聚体分离后，将上清液中保留的交联血红蛋白进行纯化，使得不需要进一步的色谱纯化步骤。 这种血红蛋白是高度交联的，绝对没有色谱细粒，并且具有低的高铁血红蛋白含量。