公开(公告)号：WO1998038091A1

公开(公告)日：1998-09-03

申请号：PCT/US1997003078

申请日：1997-02-26

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  GLINIECKI, Robert, L. ,  KIVLEHAN, John

IPC: B65B31/02

CPC classification number: B65B51/225 ,  B29C65/08 ,  B29C65/7885 ,  B29C66/001 ,  B29C66/1122 ,  B29C66/12821 ,  B29C66/1286 ,  B29C66/24221 ,  B29C66/53262 ,  B29C66/71 ,  B29L2031/7148 ,  B65B55/027 ,  B29K2023/22 ,  B29K2023/083 ,  B29K2023/06 ,  B29K2023/00 ,  B29K2021/003

Abstract: An improved apparatus (10) for filling and sealing sterile bags (12) in a sterile enclosure (14) is disclosed. A turntable (16) rotatably mounted within the enclosure suspends two or more bags. Port tubes (22) extend from the bags, and the bags are suspended from the port tubes. One of the bags is filled with sterile solution within the enclosure and the port tube is sealed by vibration welding (26). The turntable then rotates and the sequence is repeated on a new bag.

Abstract translation: 公开了一种用于在无菌外壳（14）中填充和密封无菌袋（12）的改进装置（10）。 可旋转地安装在外壳内的转盘（16）悬挂两个或更多个袋子。 端口管（22）从袋中延伸出来，并且袋从端口管悬挂。 其中一个袋子在外壳内装满无菌溶液，并通过振动焊接密封端口管（26）。 然后转盘旋转，并在新的袋子上重复序列。

公开(公告)号：WO1998020886A1

公开(公告)日：1998-05-22

申请号：PCT/US1997020074

申请日：1997-11-05

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BURHOP, Kenneth, E.

IPC: A61K38/00

CPC classification number: A61K38/42 ,  Y10S530/829

Abstract: A method for improving recovery after surgery or an invasive procedure is provided, including administering a hemoglobin preparation to a patient before surgery or an invasive procedure.

Abstract translation: 提供了一种用于改善手术后的恢复或侵入性手术的方法，包括在手术前或患有侵入性手术的情况下向患者施用血红蛋白制剂。

公开(公告)号：WO1998010713A3

公开(公告)日：1998-03-19

申请号：PCT/US1997015172

申请日：1997-08-27

Applicant: BAXTER INTERNATIONAL INC. ,  WHITE, Geoffrey, H. ,  YU, Weiyun

Inventor： BAXTER INTERNATIONAL INC. ,  DEHDASHTIAN, Mark ,  SARAVIA, Maria, Lilian

IPC: A61F02/06

公开(公告)号：WO1998006823A2

公开(公告)日：1998-02-19

申请号：PCT/US1997013759

申请日：1997-08-13

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  VACHULA, Mona ,  VAN EPPS, Dennis, E. ,  ALZONA, Mortimer, T. ,  AONO, Frederick, M.

IPC: C12N05/06

CPC classification number: C12N5/0636 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  C12N5/0639 ,  C12N2500/05 ,  C12N2500/14 ,  C12N2500/36 ,  C12N2500/38 ,  C12N2501/01 ,  C12N2501/02 ,  C12N2501/125 ,  C12N2501/22 ,  C12N2501/25 ,  C12N2501/515

Abstract: A method for producing human dendritic cells for therapeutic purposes which allows culture-deriving dendritic cells using no cytokines, or reduced cytokines. The method involves culturing mononuclear cells from blood or bone marrow in a medium containing at least one agent such as a calcium ionophore, e.g. A23187, theophylline, protaglandin E1, dibutyryl cyclic AMP, Vitamin D3, Vitamin E, retinoic acid, or a fatty acid. The culture is maintained for a sufficient time, typically 4 - 14 days, to produce a culture enriched for dendritic cells, as evidenced by at least about 2.5 % of total cells exhibiting dendritic cell processes, or a dendritic cell antigen such as CD80, CD86, or CD1a. Also provided is a method to produce antigen-specific human T-cells by pulsing the dendritic cells obtained by the method of the invention with an antigen such as a viral, tumor, bacterial, or cell surface antigen, and then co-culturing T-cells with the antigen-pulsed dendritic cells. Useful for treatment of viral or bacterial infections, useful as a cancer vaccine, useful to induce tolerance of allo- or xeno-graft.

Abstract translation: 本发明涉及一种生产用于治疗目的从培养物，而不细胞因子或具有很少的细胞因子的人树突状细胞的方法。 所述方法包括在含有至少一种剂的培养基中培养的血液或骨髓单核细胞，例如：钙离子载体（例如，A23187），茶碱，前列腺素E1，二丁酰基环AMP ，维生素D3，维生素E，视黄酸或脂肪酸。 将培养物维持足够长的时间，例如，4至14天，为生产具有的树突状细胞过程中总细胞的树突状细胞中富集至少2.5％，或细胞抗原 树突如CD80，CD86或CD1a。 本发明还涉及一种方法，用于生产抗原，其包括使用病毒抗原，细菌或肿瘤或细胞表面脉动通过上述方法获得的树突状细胞的特异性的人T细胞 然后共同培养T细胞和抗原性冲动树突状细胞。 由此获得的树突状细胞是病毒或细菌感染的治疗中是有用的，作为针对癌症的疫苗或用于感应耐受性异体或异种移植。

公开(公告)号：WO1998002113A1

公开(公告)日：1998-01-22

申请号：PCT/US1997009640

申请日：1997-05-29

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  NEUENFELDT, Steven ,  DAUGIRD, Joanne ,  BRAUKER, James ,  GELLER, Robin, L. ,  FREDERICKSEN, Scott ,  JONES, Mark ,  LOUDOVARIS, Thomas ,  MARYANOV, David ,  SHORS, Stephanie

IPC: A61F02/02

CPC classification number: A61K9/0024 ,  A61F2/0095 ,  A61F2/022 ,  A61L27/36 ,  A61L27/38

Abstract: An implant assembly and methods for loading implant devices which avoids the accidental deposition of transplanted material or other contaminates on the exterior of the device during transportation, storage, and handling are disclosed. The implant assembly of the invention may be used with a large variety of implant devices for implanting a variety of materials such as cells, tissue or other materials into a host. The implant assembly includes an implant device having an elongated port and a first chamber for holding material for implantation and a container with a second chamber for holding the implant device. The container functions to maintain the sterility and protect the physical integrity of the implant device during loading, storage, cryopreservation and transportation and is removed immediately prior to implantation of the device. The container may optionally include liquid media for cellular growth, maintenance, cryostorage, or transportation purposes.

Abstract translation: 公开了一种用于装载植入装置的植入物组件和方法，其避免了在运输，储存和处理期间移植材料或其它污染物意外沉积在装置的外部。 本发明的植入物组件可以与各种各样的植入装置一起使用，用于将诸如细胞，组织或其他材料的各种材料植入宿主体内。 植入物组件包括具有细长端口的植入装置和用于保持用于植入的材料的第一腔室和具有用于保持植入装置的第二腔室的容器。 容器用于维持无菌性并且在加载，储存，冷冻保存和运输期间保护植入物装置的物理完整性，并且在植入植入装置之前立即移除。 容器可以任选地包括用于细胞生长，维持，低温保存或运输目的的液体介质。

公开(公告)号：WO1997048483A1

公开(公告)日：1997-12-24

申请号：PCT/US1997010467

申请日：1997-06-16

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  OFSTHUN, Norma, J. ,  SOLTYS, Paul, J. ,  GRETCHEN, A., Kunas

IPC: B01D61/00

CPC classification number: B01D67/0093 ,  A61M1/3679 ,  B01D61/00 ,  B01D63/02 ,  B01D69/141 ,  B01J20/28004 ,  B01J20/28014 ,  B01J20/28021 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/28085 ,  B01J20/3242

Abstract: The present invention provides an improved affinity membrane device and method for the effective removal of target molecules in plasma. The affinity membrane device is designed for use in an extracorporeal blood circuit and can be employed concurrently with other therapeutic processes for the purification of blood. The device of the present invention consists of hollow fiber membranes having specified dimensions and transfer properties, ligand immobilized to the pore surface of the hollow fibers, and a housing to encase the hollow fibers and allow appropriate entry and exit of the blood. In a preferred embodiment, specific immobilization chemistries are utilized to attach the ligands to the hollow fibers for optimal function.

Abstract translation: 本发明提供了一种用于有效去除血浆中靶分子的改进的亲和膜装置和方法。 亲和膜装置被设计用于体外血液回路，并且可以与其他用于净化血液的治疗方法同时使用。 本发明的装置由具有特定尺寸和转移特性的中空纤维膜，固定在中空纤维的孔表面上的配体，以及包住中空纤维并允许适当进入和离开血液的壳体组成。 在优选的实施方案中，使用特定的固定化学物质将配体连接到中空纤维上以获得最佳的功能。

公开(公告)号：WO1997048366A1

公开(公告)日：1997-12-24

申请号：PCT/US1997006654

申请日：1997-04-17

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BUTTITTA, Anthony, D. ,  MUNSCH, John, M. ,  LO, Ying-Cheng ,  BELLOTTI, Marc

IPC: A61J01/00

CPC classification number: A61J1/10

Abstract: A parenteral fluid delivery bag (1) having a line set (40) formed integral with the bag, the line set being peelably releasable from the remainder of the bag so as to assume a deployed position adapted to enter into fluid communication with a patient. In an alternate embodiment, a plurality of bags (200, 222) connected by an integrally formed wye-junction (216) are adapted for delivery to a patient and retrieval of fluid from a patient.

Abstract translation: 一种肠胃外流体输送袋（1），其具有与所述袋一体形成的线组（40），所述线组可剥离地离开所述袋的其余部分，以便呈现适于与患者进行流体连通的展开位置。 在替代实施例中，通过整体形成的Y形结（216）连接的多个袋（200,222）适于递送到患者并从患者回收流体。

公开(公告)号：WO1997039027A1

公开(公告)日：1997-10-23

申请号：PCT/US1997005621

申请日：1997-04-03

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  HAI, Ton, T. ,  NELSON, Deanna, J.

IPC: C07K14/00

CPC classification number: A61K38/42

Abstract: Hemoglobin solutions intended for parenteral administration are stabilized against oxidation of the heme iron to the ferric oxidation state by adding stabilizer compounds to the solutions. The stabilizer compounds are generally alpha-hydroxycarboxylic acids and their salts. The particular compounds are selected for their efficacy in defined temperature ranges, and for their ability to retard methemoglobin formation both in solution and in the frozen state.

Abstract translation: 用于肠胃外给药的血红蛋白溶液通过向溶液中加入稳定剂化合物而使血红素铁氧化成三价铁氧化态稳定。 稳定剂化合物通常是α-羟基羧酸及其盐。 选择特定的化合物用于在确定的温度范围内的功效，以及它们在溶液和冷冻状态下延缓高铁血红蛋白形成的能力。

公开(公告)号：WO1997015230A1

公开(公告)日：1997-05-01

申请号：PCT/US1996017154

申请日：1996-10-25

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MCKOWN, Russell

IPC: A61B05/028

CPC classification number: A61B5/028 ,  A61B5/029 ,  A61B5/7257

Abstract: Cardiac output CO is separately estimated in a local estimator (118) and a trend estimator (120) to provide CO values. A preferably thermal indicator is injected preferably according to a pseudo-random binary sequence signal (x(t)) profile at an upstream position in a blood flow region of a patient's body and is sensed as an indicator (108) output signal (y(t)) at a downstream position. Low-frequency noise is preferably removed from the sensed indicator output signal. The local and trend estimations are based on measured frequency-domain transfer function values between the sensed and input indicator signal in relation to a pre-determined transfer function model, which is preferably a lagged normal model. The trend estimator is preferably a Kalman filter. The local estimator preferably forms its estimate based on non-recursive optimization of a cost function. The local estimator preferably provides initial values to start the trend estimator.

Abstract translation: 在局部估计器（118）和趋势估计器（120）中分别估计心输出量CO以提供CO值。 优选地，根据患者身体的血流区域中的上游位置处的伪随机二进制序列信号（x（t））轮廓注入优选的热指示器，并将其作为指示符（108）输出信号（y（ t））。 优选地，从感测到的指示符输出信号中去除低频噪声。 局部和趋势估计基于感测和输入指示符信号之间相对于预定传递函数模型的测量的频域传递函数值，其优选地是滞后的正常模型。 趋势估计器优选地是卡尔曼滤波器。 本地估计器优选地基于成本函数的非递归优化来形成其估计。 本地估计器优选地提供初始值以启动趋势估计器。

公开(公告)号：WO1997005834A1

公开(公告)日：1997-02-20

申请号：PCT/US1996012929

申请日：1996-08-06

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  RHEE, Richard ,  GUO, George ,  OH, Seik

IPC: A61F02/24

CPC classification number: A61F2/2403

Abstract: A bileaflet mechanical cardiovascular valve having a generally annular valve body (12) and two occluder leaflets (14) mounted within the valve body (12) such that the occluder leaflets (14) will move back and forth between an open configuration wherein blood is permitted to flow through the annular valve body (12) and a closed configuration wherein blood is prevented from flowing in at least one direction through the annular valve body (12). Slots (20) formed in opposite ends of the occluder leaflets (14) are mounted upon raised mounting members (18) formed on the inner surface of the annular valve body (12) to facilitate the opening and closing movement of the occluder leaflets (14).

Abstract translation: 一种双回路机械心血管瓣膜，其具有安装在所述阀体（12）内的大致环形的阀体（12）和两个闭塞器小叶（14），使得所述封堵器传单（14）将在允许血液的打开构型之间来回移动 流过环形阀体（12）和闭合构造，其中防止血液在至少一个方向上流过环形阀体（12）。 形成在封堵器小叶（14）的相对端的狭槽（20）安装在形成在环形阀体（12）的内表面上的凸起的安装构件（18）上，以便于封闭器传单（14）的打开和关闭 ）。