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    Cuvette Having High Optical Transmissivity and Method of Forming
    91.
    发明申请
    Cuvette Having High Optical Transmissivity and Method of Forming 审中-公开

    公开(公告)号：US20190170633A1

    公开(公告)日：2019-06-06

    申请号：US16212347

    申请日：2018-12-06

    Applicant: California Institute of Technology

    Inventor： Axel Scherer ,  Amirhossein Nateghi ,  Taeyoon Jeon ,  Frank T. Hartley

    IPC: G01N21/03

    CPC classification number: G01N21/0303 ,  G01N1/42 ,  G01N1/44 ,  G01N21/171 ,  G01N21/255 ,  G01N21/35 ,  G01N21/3504 ,  G01N21/3577

    Abstract: The present disclosure is directed toward a cuvette for holding a test sample during optical interrogation with a light signal. The transmissivity of the cuvette is increased by a geometric anti-reflection layer disposed on at least one surface of the cuvette, where the geometric anti-reflection layer includes a plurality of geometric features that collectively reduce the reflectivity of the interface between the surface and another medium. As a result, more of the interrogation signal passes through the interface. In some embodiments, every surface through which the interrogation signal passes includes a geometric anti-reflection layer. Due to the increased transmissivity of the cuvette, light detected after passing through it can have an improved signal-to-noise ratio and/or the light signal used to interrogate the sample can have lower intensity. In addition, the reduction of the reflectivity of each surface enables the use of low-cost, high-refractive-index materials, such as conventional silicon.

    Methods and apparatuses for nucleic acid purification
    98.
    发明授权
    Methods and apparatuses for nucleic acid purification 有权

    公开(公告)号：US09624487B2

    公开(公告)日：2017-04-18

    申请号：US14069697

    申请日：2013-11-01

    Applicant: California Institute of Technology

    Inventor： Samuel Njoroge ,  George Maltezos ,  Axel Scherer ,  John B. Gorman

    IPC: C12N15/10 ,  B01D15/22

    CPC classification number: C12N15/101 ,  B01D15/22

    Abstract: An apparatus for purifying nucleic acid can include a disposable cartridge having a layered configuration, and a disposable syringe for coupling to the disposable cartridge such that a fluid can be delivered to or withdrawn fluid from the disposable cartridge using the syringe. At least one layer of the disposable cartridge can include a cut-out for forming a functional unit of the disposable cartridge, and at least one layer of the disposable cartridge can be joined to an adjacent layer of the disposable cartridge by an adhesive material layer. The functional unit can include a fluid channel between an access port on the first surface of the disposable cartridge and the fluid pouch. The apparatus can include a disposable silica-containing material for binding with the nucleic acid. The apparatus can include a heating element and a temperature sensor for heating the disposable silica-containing material.

    Mid-infrared hyperspectral spectroscopy systems and methods therefor
    100.
    发明授权
    Mid-infrared hyperspectral spectroscopy systems and methods therefor 有权
    中红外光谱系统及其方法

    公开(公告)号：US09518917B2

    公开(公告)日：2016-12-13

    申请号：US15065792

    申请日：2016-03-09

    Applicant: California Institute of Technology

    Inventor： Axel Scherer ,  Frank T. Hartley

    IPC: G01N21/35 ,  G01J3/42 ,  G01N21/3577 ,  G01J3/28

    CPC classification number: G01N21/35 ,  G01J3/0208 ,  G01J3/0256 ,  G01J3/18 ,  G01J3/36 ,  G01J3/42 ,  G01J2003/1213 ,  G01N21/3577

    Abstract: MIR spectroscopy systems comprising hierarchical spectral dispersion that enables fine spectral resolution and high sensitivity spectroscopy are disclosed. Hierarchical spectral dispersion is derived by employing at least two diffractive lens arrays, located on either side of a test sample, each receiving input radiation having an input spectral range and distributing the input radiation into a plurality of output signals, each having a fraction of the spectral range of the input radiation. As a result, the signal multiplication factor of the two arrays is multiplied in a manner that mitigates the propagation of wavelength harmonics through the system. In some embodiments, an emitter array comprising a plurality of spectrally selective emitters provides the input MIR radiation to a spectroscopy system. In some embodiments, spectrally selective detectors are used to detect narrow spectral components in the radiation after they have passed through the test sample.

    Abstract translation: 公开了包括能够进行精细光谱分辨率和高灵敏度光谱的分级光谱色散的MIR光谱系统。 通过采用位于测试样本两侧的至少两个衍射透镜阵列来导出分层光谱色散，每个衍射透镜阵列接收具有输入光谱范围的输入辐射并将输入辐射分配成多个输出信号，每个输出信号具有 输入辐射的光谱范围。 结果，两个阵列的信号乘法因子以减轻波长谐波通过系统的传播的方式相乘。 在一些实施例中，包括多个光谱选择性发射器的发射器阵列将输入MIR辐射提供给光谱系统。 在一些实施例中，光谱选择性检测器用于在它们通过测试样品之后检测辐射中的窄光谱分量。

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