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    BENZODIAZEPINE FORMULATION IN A POLYORTHOESTER CARRIER
    92.
    发明申请
    BENZODIAZEPINE FORMULATION IN A POLYORTHOESTER CARRIER 审中-公开
    多氯联苯载体中的苯二酚配方

    公开(公告)号：WO2009129519A2

    公开(公告)日：2009-10-22

    申请号：PCT/US2009041068

    申请日：2009-04-20

    Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

    Inventor： HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

    IPC: A61K47/34 ,  A61K31/197

    CPC classification number: A61K31/197 ,  A61K9/0024 ,  A61K47/34

    Abstract: Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    Abstract translation: 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

    SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL
    93.
    发明申请
    SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL 审中-公开
    生物可降解材料中的SULINDAC配方

    公开(公告)号：WO2009129510A2

    公开(公告)日：2009-10-22

    申请号：PCT/US2009041042

    申请日：2009-04-17

    Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  COX S MARK ,  SHAW KATARA

    Inventor： ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  COX S MARK ,  SHAW KATARA

    IPC: A61K9/00 ,  A61K31/255 ,  A61P29/00

    CPC classification number: A61K31/255 ,  A61K9/0024 ,  A61K9/204

    Abstract: Effective treatments of pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulindac or a pharmaceutically acceptable salt thereof at or near a target site, one can relieve pain and/or inflammation caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days, at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    Abstract translation: 提供了长时间疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的舒林酸或其药学上可接受的盐，可以减轻由不同来源引起的疼痛和/或炎症，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位， 狭窄，恶性背痛和关节疼痛以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天，至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    ELONGATED BIODEGRADABLE DEPOT FOR SUSTAINED DRUG RELEASE TO TREAT CHRONIC PELVIC PAIN
    95.
    发明申请
    ELONGATED BIODEGRADABLE DEPOT FOR SUSTAINED DRUG RELEASE TO TREAT CHRONIC PELVIC PAIN 审中-公开
    用于持续释放药物治疗慢性盆腔疼痛的可延长的生物可降解储室

    公开(公告)号：WO2011139595A3

    公开(公告)日：2012-05-31

    申请号：PCT/US2011033545

    申请日：2011-04-22

    Applicant: MEDTRONIC INC ,  BISCHOFF THOMAS C ,  HILDEBRAND KEITH R ,  HOBOT CHRISTOPHER M

    Inventor： BISCHOFF THOMAS C ,  HILDEBRAND KEITH R ,  HOBOT CHRISTOPHER M

    IPC: A61K9/70 ,  A61K9/00

    CPC classification number: A61K9/0085 ,  A61B17/3401 ,  A61K9/0024

    Abstract: The invention describes a device for administering a therapeutic agent to a subject at a sustained rate over a period of time, the device being shaped, sized and adapted for administering the therapeutic agent into the region of the spinal column of the subject, the device comprising: an elongated first polymeric substrate having a proximal end, a distal end and diameter or width of about 1 mm to about 10 mm and a length of about 4 cm to about 35 cm; optionally, an elongated second polymeric substrate positioned within the first polymeric substrate; and at least one therapeutic agent, loaded into or onto the first polymeric substrate or second polymeric substrate or both, wherein the therapeutic agent is available for diffusion into the region of the spinal column of the subject.

    Abstract translation: 本发明描述了一种用于在一段时间内以持续的速率向对象施用治疗剂的装置，所述装置的形状，大小和适合于将治疗剂施用到对象脊柱的区域中，所述装置包括 ：细长的第一聚合物基底，其具有近端，远端以及约1mm至约10mm的直径或宽度和约4cm至约35cm的长度; 任选地，位于第一聚合物基材内的细长的第二聚合物基材; 和至少一种治疗剂，其被装载到第一聚合物基底或第二聚合物基底中或两者之中或之上，其中治疗剂可用于扩散到受试者的脊柱区域中。

    CLONIDINE FORMULATION IN A POLYORTHOESTER CARRIER
    96.
    发明申请
    CLONIDINE FORMULATION IN A POLYORTHOESTER CARRIER 审中-公开
    多聚体载体中的克隆配位体

    公开(公告)号：WO2009129453A4

    公开(公告)日：2010-04-08

    申请号：PCT/US2009040940

    申请日：2009-04-17

    Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  HILDEBRAND KEITH R

    Inventor： HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  HILDEBRAND KEITH R

    IPC: A61K47/34 ,  A61K9/20 ,  A61K31/415 ,  A61P29/00

    CPC classification number: A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/415 ,  A61K47/34

    Abstract: Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    Abstract translation: 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

    CLONIDINE FORMULATION IN A POLYORTHOESTER CARRIER
    97.
    发明申请
    CLONIDINE FORMULATION IN A POLYORTHOESTER CARRIER 审中-公开
    多烯酯载体中的克罗尼定制剂

    公开(公告)号：WO2009129453A3

    公开(公告)日：2010-02-18

    申请号：PCT/US2009040940

    申请日：2009-04-17

    Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  HILDEBRAND KEITH R

    Inventor： HOBOT CHRISTOPHER M ,  MCDONALD PHILLIP EDWARD ,  HILDEBRAND KEITH R

    IPC: A61K47/34 ,  A61K9/20 ,  A61K31/415 ,  A61P29/00

    CPC classification number: A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/415 ,  A61K47/34

    Abstract: Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    Abstract translation: 提供长时间有效的急性疼痛治疗。 治疗包括在目标部位或其附近给药一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过在目标部位或其附近施用一个或多个药物贮库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎间盘突出症（即坐骨神经痛），导丝术，狭窄，椎间盘源性背痛和关节疼痛 作为伴随手术的疼痛。 在一些实施方案中，缓解剂可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

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