公开(公告)号：RS52644B

公开(公告)日：2013-06-28

申请号：RSP20130056

申请日：2009-08-04

Applicant: SERVIER LAB

Inventor： BONTEMPELLI PASCAL ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: C07C231/02 ,  C07C209/48 ,  C07C231/10 ,  C07C233/18

Abstract: Process for industrial synthesis of N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide (agomelatine) (I) comprises reacting (7-methoxy-1-naphtyl)acetonitrile, which is subjected to a reduction by hydrogen in the presence of Raney nickel in medium containing acetic anhydride in a polar protic medium to give (I) that is isolated as a solid. ACTIVITY : Antidepressant; Hypnotic; Cardiovascular-Gen.; Gastrointestinal-Gen.; CNS-Gen.; Muscular-Gen.; Eating-Disorders-Gen.; Anorectic. MECHANISM OF ACTION : 5-Hydroxytryptamine 2C receptor antagonist.

公开(公告)号：ECSP099550A

公开(公告)日：2010-03-31

申请号：ECSP099550

申请日：2009-07-31

Applicant: SERVIER LAB

Inventor： BONTEMPELLI PASCAL ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: A61K31/44 ,  C07D213/74

Abstract: Procedimiento de síntesis industrial del compuesto de fórmula (I):

公开(公告)号：PH12014000194B1

公开(公告)日：2015-06-29

申请号：PH12014000194

申请日：2014-07-08

Applicant: SERVIER LAB

Inventor： LE TIRAN ARNAUD ,  LE DIGUARHER THIERRY ,  STARCK JEROME-BENOIT ,  HENLIN JEAN-MICHEL ,  GUILLOUZIC ANNE-FRANCOISE ,  DE NANTEUIL GUILLAME ,  GENESTE OLIVIER ,  DAVIDSON JAMES EDWARD PAUL ,  MURRAY JAMES BROOKE ,  CHEN I-JEN

IPC: A61K31/407 ,  A61K31/4353 ,  A61K31/437 ,  C07D471/00 ,  C07D471/04

Abstract: The present invention relates to new phosphate compounds, to a process for their preparation and to pharmaceutical compositions containing them. The compounds of the present invention are new and have very valuable pharmacological and pharmacokinetic characteristics for use in the field of apoptosis and cancerology. Apoptosis, or programmed cell death, is a physiological process that is crucial for embryonic development and maintenance of tissue homeostasis. In addition to being new, the compounds of the present invention have pharmacological and pharmacokinetic properties making it possible to use them in pathologies involving a defect in apoptosis, such as, for example, in the treatment of cancer, auto-immune diseases and diseases of the immune system.

公开(公告)号：AP2014007882A0

公开(公告)日：2014-08-31

申请号：AP2014007882

申请日：2013-01-23

Applicant: SERVIER LAB

Inventor： HENLIN JEAN-MICHEL ,  STARCK JEROME-BENOIT ,  DIGUARHER THIERRY LE

IPC: C07D471/00 ,  A61K31/407 ,  A61K31/4353 ,  A61K31/436 ,  A61P35/00 ,  A61P37/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

Abstract: wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

公开(公告)号：ES2401534T3

公开(公告)日：2013-04-22

申请号：ES09290605

申请日：2009-08-04

Applicant: SERVIER LAB

Inventor： BONTEMPELLI PASCAL ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: C07C231/02 ,  C07C209/48 ,  C07C231/10 ,  C07C233/18

Abstract: Procedimiento de síntesis industrial del compuesto de la fórmula (I) caracterizado porque se hace reaccionar un (7-metoxi-1-naftil)acetonitrilo de la fórmula (II): que se somete a una reducción por hidrógeno en presencia de níquel Raney, en un medio que contieneanhídrido acético, en un medio de reacción que contiene etanol y agua, para obtener el compuesto de lafórmula (I), que se aísla en forma de un sólido.

公开(公告)号：CU23861B1

公开(公告)日：2013-03-27

申请号：CU20090139

申请日：2009-08-04

Applicant: SERVIER LAB

Inventor： SERY JEAN-PIERRE ,  STARCK JEROME-BENOIT ,  JALENQUES XAVIER ,  BONTEMPELLI PASCAL

公开(公告)号：CU20090139A7

公开(公告)日：2012-06-21

申请号：CU20090139

申请日：2009-08-04

Applicant: SERVIER LAB

Inventor： SERY JEAN-PIERRE ,  STARCK JEROME-BENOIT ,  JALENQUES XAVIER ,  BONTEMPELLI PASCAL

IPC: C07B61/00 ,  C07C231/02 ,  C07C233/18 ,  C07C235/30

Abstract: Procedimiento de síntesis industrial del compuesto de fórmula: ESPACIO PARA LA FÓRMULA

公开(公告)号：MX2009008047A

公开(公告)日：2010-03-23

申请号：MX2009008047

申请日：2009-07-29

Applicant: SERVIER LAB

Inventor： BONTEMPELLI PASCAL ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: C07C231/02 ,  C07C209/48 ,  C07C231/10 ,  C07C233/18

Abstract: Procedimiento de síntesis industrial del compuesto de fórmula (I): (ver fórmula I).

公开(公告)号：AU2009203052A1

公开(公告)日：2010-02-25

申请号：AU2009203052

申请日：2009-07-27

Applicant: SERVIER LAB

Inventor： SERY JEAN-PIERRE ,  BONTEMPELLI PASCAL ,  STARCK JEROME-BENOIT ,  JALENQUES XAVIER

IPC: C07C233/18 ,  C07C231/06 ,  C07C255/37

Abstract: Process for industrial synthesis of N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide (agomelatine) (I) comprises reacting (7-methoxy-1-naphtyl)acetonitrile, which is subjected to a reduction by hydrogen in the presence of Raney nickel in medium containing acetic anhydride in a polar protic medium to give (I) that is isolated as a solid. ACTIVITY : Antidepressant; Hypnotic; Cardiovascular-Gen.; Gastrointestinal-Gen.; CNS-Gen.; Muscular-Gen.; Eating-Disorders-Gen.; Anorectic. MECHANISM OF ACTION : 5-Hydroxytryptamine 2C receptor antagonist.

公开(公告)号：SV2009003342A

公开(公告)日：2010-02-01

申请号：SV2009003342

申请日：2009-07-29

Applicant: SERVIER LAB

Inventor： BONTEMPELLI PASCAL ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: A61K31/00 ,  C07C253/00

Abstract: PROCEDIMIENTO DE SÍNTESIS INDUSTRIAL DEL COMPUESTO DE FÓRMULA (I): (VER FORMULA)