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公开(公告)号：US20120252704A1
公开(公告)日：2012-10-04
申请号：US13486399
申请日：2012-06-01
Applicant: Claudia B. Jaffe , Steven M. Jaffe , Michieal L. Jones
Inventor： Claudia B. Jaffe , Steven M. Jaffe , Michieal L. Jones
CPC classification number: G01J3/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/51 , G01N21/53 , G01N21/6452 , G01N2021/6419 , G01N2021/6469 , G01N2021/6484 , G01N2201/06193
Abstract: The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.
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公开(公告)号：US08173974B2
公开(公告)日：2012-05-08
申请号：US12869788
申请日：2010-08-27
Applicant: Yan Zheng , Jingyu Bian , Shufan Geng , Ruifu Yang , Lei Zhou , Huijie Huang , Youbao Zhang , Lihua Huang
Inventor： Yan Zheng , Jingyu Bian , Shufan Geng , Ruifu Yang , Lei Zhou , Huijie Huang , Youbao Zhang , Lihua Huang
IPC: G01J1/58
CPC classification number: G01N21/6428 , B82Y15/00 , B82Y20/00 , G01N2021/6441 , G01N2201/06193
Abstract: A method of indirect emission by nano-materials includes providing an infrared up-conversion phosphor 1 (weight ratio) and a long-wave ultraviolet phosphor 0.01-10 (weight ratio); treating both surfaces of the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; mixing the infrared up-conversion phosphor and the long-wave ultraviolet phosphor; exciting the infrared up-conversion phosphor by a near-infrared laser with a wavelength of 980 mn to emit blue light as a secondary excitation lightsource; exciting the long-wave ultraviolet phosphor by the blue light to emit a visible light. Biological reactions can be conveniently detected by detecting the visible light.
Abstract translation: 纳米材料间接发射的方法包括提供红外线上转换荧光体1（重量比）和长波紫外线荧光粉0.01-10（重量比）; 处理红外线上变换荧光体和长波紫外线荧光体的两面; 混合红外线上转换荧光体和长波紫外线荧光体; 通过波长980nm的近红外激光激发红外上转换荧光体，发射蓝光作为次级激发光源; 通过蓝光激发长波紫外线荧光体发出可见光。 通过检测可见光可以方便地检测生物反应。
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公开(公告)号：US20110084208A1
公开(公告)日：2011-04-14
申请号：US12798894
申请日：2010-04-13
Applicant: Frank V. Bright , William G. Holthoff , Elizabeth C. Tehan
Inventor： Frank V. Bright , William G. Holthoff , Elizabeth C. Tehan
CPC classification number: G01N21/6408 , G01N21/6428 , G01N21/6452 , G01N2021/6432 , G01N2021/7786 , G01N2201/061 , G01N2201/06193
Abstract: A photonic sensor system is provided. The system generally includes a beta emission source, optionally, a scintillation layer, and a luminophore-containing sensory layer. The system can be embodied in a particle. Also provided are photonic sensor strategies which are highly accurate and photonic sensors which are highly stable.
Abstract translation: 提供了一种光子传感器系统。 该系统通常包括β发射源，任选的闪烁层和含发荧光的感觉层。 该系统可以体现在一个粒子中。 还提供了高度准确的光子传感器策略和高度稳定的光子传感器。
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公开(公告)号：US07846391B2
公开(公告)日：2010-12-07
申请号：US11805185
申请日：2007-05-21
Applicant: Claudia B. Jaffe , Steven M. Jaffe , Michieal L. Jones
Inventor： Claudia B. Jaffe , Steven M. Jaffe , Michieal L. Jones
CPC classification number: G01J3/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/51 , G01N21/53 , G01N21/6452 , G01N2021/6419 , G01N2021/6469 , G01N2021/6484 , G01N2201/06193
Abstract: The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.
Abstract translation: 本发明涉及用于用存在于检测体积中的分子照射一种或多种所选波长的光并将荧光，吸光度，透射率，散射引导到一个或多个检测器上的光源。 与光的分子相互作用允许使用物理或化学标签（最常见的荧光和发色团标记）在反应中鉴定和定量参与的化学部分。 本发明还可以使用光源单独地并且同时用一个或多个选择的波长的光照射多个毛细管或其它流动约束结构，并且分别并且同时检测在毛细管或其它流动限制结构内产生的荧光。 在各种实施方案中，流动限制结构可以允许分子的分离或运输，并且包括毛细管，微孔和毫里流系统。 毛细血管用于分离用适当荧光或发色团组化学标记的分子。
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公开(公告)号：US20100202726A1
公开(公告)日：2010-08-12
申请号：US12697233
申请日：2010-01-30
Applicant: Claudio Oliveira Egalon
Inventor： Claudio Oliveira Egalon
CPC classification number: G01N21/251 , G01D5/353 , G01D5/35345 , G01D5/35387 , G01F23/2927 , G01N21/17 , G01N21/64 , G01N21/645 , G01N21/648 , G01N21/76 , G01N21/7703 , G01N2021/635 , G01N2021/6484 , G01N2021/7736 , G01N2201/06193 , G01N2201/062 , G01N2201/088 , G02B6/00
Abstract: A side illuminated multi point multi parameter optical fiber sensor that requires no sensitive coating is provided. This sensor comprises an optical fiber having at least one removed cladding section as the sensitive region, at least one probing light source that side illuminates the fiber, a power supply, a detector, a signal processor and a display. The sensitive optical fiber is optically affected by the presence of a measurand medium that can fluoresce, phosphoresce, absorb and/or scatter the probing light. This probing light is guided by the fiber core towards a detector which measures the light intensity and this light intensity is correlated with a measurand.
Abstract translation: 提供不需要敏感涂层的侧面照明多点多参数光纤传感器。 该传感器包括具有至少一个去除的包层部分作为敏感区域的光纤，该侧面照射光纤的至少一个探测光源，电源，检测器，信号处理器和显示器。 敏感光纤受到可以荧光，磷光吸收，吸收和/或散射探测光的被测量介质的存在的光学影响。 该探测光由光纤芯引向测量光强度的检测器，该光强度与被测量相关。
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Patent Agency Ranking
公开(公告)号：US20100001185A1
公开(公告)日：2010-01-07
申请号：US11076729
申请日：2005-03-10
Applicant: Frank V. Bright , William G. Holthoff , Elizabeth C. Tehan
Inventor： Frank V. Bright , William G. Holthoff , Elizabeth C. Tehan
IPC: G01N23/00
CPC classification number: G01N21/6408 , G01N21/6428 , G01N21/6452 , G01N2021/6432 , G01N2021/7786 , G01N2201/061 , G01N2201/06193
Abstract: A photonic sensor system is provided. The system generally includes a beta emission source, optionally, a scintillation layer, and a luminophore-containing sensory layer. The system can be embodied in a particle. Also provided are photonic sensor strategies which are highly accurate and photonic sensors which are highly stable.
Abstract translation: 提供了一种光子传感器系统。 该系统通常包括β发射源，任选的闪烁层和含发荧光的感觉层。 该系统可以体现在一个粒子中。 还提供了高度准确的光子传感器策略和高度稳定的光子传感器。
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公开(公告)号：US07436517B2
公开(公告)日：2008-10-14
申请号：US11392588
申请日：2006-03-30
Applicant: Hiroyuki Hiiro
Inventor： Hiroyuki Hiiro
CPC classification number: G01J3/02 , G01J3/0218 , G01J3/10 , G01N21/4795 , G01N2201/06193
Abstract: Excitation light is inputted to an optical element with uniformly dispersed inorganic fluorescent nanoparticles whose radius is controlled. Fluorescence is emitted from the inorganic fluorescent nanoparticles through photoexcitation and outputted from one end of the optical element. By controlling the radius of the inorganic fluorescent nanoparticles dispersed in the optical element, the wavelength range and spectral width of the light outputted from the optical element are controlled.
Abstract translation: 激发光被输入到具有半径被控制的均匀分散的无机荧光纳米粒子的光学元件。 通过光激发从无机荧光纳米粒子发射荧光，并从光学元件的一端输出荧光。 通过控制分散在光学元件中的无机荧光纳米颗粒的半径，控制从光学元件输出的光的波长范围和光谱宽度。
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公开(公告)号：US20060221345A1
公开(公告)日：2006-10-05
申请号：US11392588
申请日：2006-03-30
Applicant: Hiroyuki Hiiro
Inventor： Hiroyuki Hiiro
CPC classification number: G01J3/02 , G01J3/0218 , G01J3/10 , G01N21/4795 , G01N2201/06193
Abstract: Excitation light is inputted to an optical element with uniformly dispersed inorganic fluorescent nanoparticles whose radius is controlled. Fluorescence is emitted from the inorganic fluorescent nanoparticles through photoexcitation and outputted from one end of the optical element. By controlling the radius of the inorganic fluorescent nanoparticles dispersed in the optical element, the wavelength range and spectral width of the light outputted from the optical element are controlled.
Abstract translation: 激发光被输入到具有半径被控制的均匀分散的无机荧光纳米粒子的光学元件。 通过光激发从无机荧光纳米粒子发射荧光，并从光学元件的一端输出荧光。 通过控制分散在光学元件中的无机荧光纳米颗粒的半径，控制从光学元件输出的光的波长范围和光谱宽度。
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公开(公告)号：US11808703B2
公开(公告)日：2023-11-07
申请号：US17045876
申请日：2020-10-02
Applicant: The Regents of the University of California
Inventor： Farzad Fereidouni , Richard M. Levenson
CPC classification number: G01N21/6458 , G02B21/12 , G02B21/16 , G01N2021/6439 , G01N2201/06193
Abstract: The disclosed embodiments provide a system that images a tissue sample. During operation, the system receives the tissue sample, which has been stained using absorbing and fluorescently emitting stains. Next, the system illuminates the tissue sample with excitation light having a wavelength or wavelengths in a range that covers a portion of an absorption spectrum for both fluorescently emitting and absorbing stains, whereby the excitation light interacts with stained tissue located inside the tissue sample to both limit penetration depth and generate emitted dye fluorescence and tissue autofluorescence that provides a backlight, which is absorbed by features in stained tissue located on or near the surface of the tissue sample. Next, the system uses an imaging device to capture an image of emitted fluorescence that emanates from the surface of the tissue sample.
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公开(公告)号：US20180274384A1
公开(公告)日：2018-09-27
申请号：US15916612
申请日：2018-03-09
Applicant: ExxonMobil Research and Engineering Company
Inventor： Christopher Vander Neut , Steven M. Jetter , Michael L. Alessi
CPC classification number: F01D17/08 , F01D17/26 , G01N21/25 , G01N21/64 , G01N21/645 , G01N21/85 , G01N21/8806 , G01N33/28 , G01N33/2888 , G01N2021/6439 , G01N2201/06193
Abstract: A working fluid monitoring system for monitoring a working fluid of a working fluid system of a piece of equipment. The working fluid monitoring system can include a housing member having a working fluid passage for receiving the working fluid therein and a sensor in operable communication with the working fluid within the working fluid passage of the housing member configured to monitor in situ the working fluid and output a sensor signal. The working fluid monitoring system can be quickly and conveniently retrofitted to existing machinery for in situ monitoring, detecting, testing, and/or validating of a working fluid, such as oil, hydraulic fluid, and the like.
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