Abstract:
Device to detect at least an analyte, comprising a transparent substrate (2), having a first surface (3) with which a light source (7) is associated, and a second surface (4) on which a plurality of biological protein probes (12) are disposed, a layer (6) of polymer being interposed between said second surface (4) and said biological protein probes (12). A marker (fluorophore) is associated with said analyte, having determinate characteristics of fluorescence and/or phosphorescence correlated to the emission wavelength of the light source (7). Said light source (7) is suitable to emit a light radiation in a range of wavelengths equal to 400-550 nm, inside which range the absorption peak of said marker (fluorophore) used is comprised. The value of the distance (“s”) between the wavelength corresponding to the absorption peak of the marker (fluorophore) and the wavelength corresponding to the emission peak of fluorescence (phosphorescence) is comprised between 25 and 150 nm.
Abstract:
An integrated test element (110) is proposed for detecting for detecting at least one analyte in a sample (142), in particular in a liquid sample (142). The integrated test element (110) has a carrier element (112), with an application face (114) on which at least one organic electroluminescent component (126) is applied. Furthermore, at least one indicator substance (136) is applied on the application face (114), which indicator substance (136) alters at least one optical characteristic, in particular an emission characteristic (e.g. a fluorescence characteristic), when it comes into contact with the at least one analyte. Furthermore, the integrated test element (110) has at least one photodetector element (116).
Abstract:
The compact microspectrometer for fluid media has, in a fixed spatial coordination in a housing, a light source, a fluid channel, a reflective diffraction grating, and a detector. The optical measuring path starting from the light source passes through the fluid channel and impinges on the diffraction grating. The spectral light components reflected by the diffraction grating impinge on the detector.
Abstract:
The invention relates to an optical sensor comprising at least one detection module which comprises an organic light emitting diode (1) and an organic detection photodiode (2, 2a) for measuring emitted light which during the use of the sensor reaches the photodiode via the sample holder. Optionally, a sensor according to the invention further comprises a plastic waveguide.
Abstract:
The invention concerns an optical inspection method for the line inspection of transparent or translucent objects (2) travelling at fast rate between a light source (3) and means (4) to take images of the objects and to analyze the images taken, so as to detect defects in the objects.According to the invention, the method consists of: controlling the single light source (3) so that said source successively produces two types of illumination for each object travelling in front of said source, the first type being homogeneous illumination whilst the second type is formed of alternate dark areas (s) and light areas (c) with discontinuous spatial variability, taking images of each travelling object when each thereof is successively illuminated by both types of lighting, and analyzing the images taken with the first and second types of illumination, with a view to detecting high contrast defects and low contrast defects respectively
Abstract:
An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
Abstract:
An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.
Abstract:
A sensor, such as a lateral flow sensor, which includes a chemical layer and a detector on a flexible substrate. An optical signal is produced in response to an analyte placed on the chemical layer. The detector detects the signal, to thereby detect the presence, absence or concentration of the analyte. The detector is on the substrate. The chemical layer and the substrate are laminated together, to thereby form an integrated sensor. The sensor can include a light source. The light source can be on the substrate, or on an opposite side of the chemical layer than the detector.
Abstract:
The invention concerns a measuring device for the optical analysis of a diagnostic test element (10) comprising a light source (16), a photodetector (24) and a device (12) for positioning the test element (10) between the light source (16) and photodetector (24) where the light source (16) has one or several organic light-emitting diodes (OLEDs) and the OLEDs (14) for a composite structure with an imaging optics (20) and/or a photodetector (24) by means of a support substrate.
Abstract:
An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.