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    Extended release preparation
    91.
    发明授权
    Extended release preparation 有权
    延长释放准备

    公开(公告)号：US08912192B2

    公开(公告)日：2014-12-16

    申请号：US13578323

    申请日：2011-02-10

    Applicant: Noriyuki Hirasawa ,  Nobuyoshi Kamikido ,  Akihiko Tasaki ,  Shusei Ito

    Inventor： Noriyuki Hirasawa ,  Nobuyoshi Kamikido ,  Akihiko Tasaki ,  Shusei Ito

    IPC: C07D201/00 ,  A61K31/501 ,  A61K9/20

    CPC classification number: A61K31/501 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095

    Abstract: Disclosed is a sustained release preparation which releases a poorly soluble medicinal agent in a pH-independent manner. Also disclosed is a sustained release preparation which is capable of controlling the Cmax of a medicinal agent to an adequate amount and is thus capable of maintaining the level of the medicinal agent in the blood to a level at which medicinal effects can be expected for a long period of time. Specifically disclosed is a sustained release preparation which is characterized by containing a pharmaceutically acceptable salt of 4-bromo-6-[3-(4-chlorophenyl)propoxy]-5-(3-pyridylmethylamino)-3(2H)-pyridazinone, and hypromellose. An organic acid is blended in the sustained release preparation in an amount of less than 1% by mass.

    Abstract translation: 公开了一种以pH不依赖的方式释放难溶性药物的缓释制剂。 还公开了一种能够将药剂的Cmax控制在足够量的缓释制剂，因此能够将血液中的药剂的水平维持在长期以来可以期待药效的水平 一段的时间。 具体公开的是持续释放制剂，其特征在于含有4-溴-6- [3-（4-氯苯基）丙氧基] -5-（3-吡啶基甲基氨基）-3（2H） - 哒嗪酮的药用盐， 羟丙甲纤维素 持续释放制剂中的有机酸以小于1质量％的量共混。

    2-Hydroxyphenyl-s-triazine crosslinkers for polymer networks
    96.
    发明申请
    2-Hydroxyphenyl-s-triazine crosslinkers for polymer networks 有权
    用于聚合物网络的2-羟基苯基-s-三嗪交联剂

    公开(公告)号：US20050075465A1

    公开(公告)日：2005-04-07

    申请号：US10497297

    申请日：2002-11-21

    Applicant: Thomas Bolle ,  Andreas Valet ,  David Leppard ,  Stephen Andrews ,  Ramanathan Ravichandran ,  Markus Grob ,  Dirk Simon

    Inventor： Thomas Bolle ,  Andreas Valet ,  David Leppard ,  Stephen Andrews ,  Ramanathan Ravichandran ,  Markus Grob ,  Dirk Simon

    IPC: C07D251/24 ,  C08F8/30 ,  C08F291/00 ,  C08K5/3492 ,  C08L101/00 ,  C07D201/00 ,  C08F20/00 ,  C09K3/00

    CPC classification number: C08F8/30 ,  C07D251/24 ,  C08F291/00 ,  C08K5/3492 ,  C08F222/1006

    Abstract: Compounds of the general formula I′ in which R1 is H, C1-C12alkyl; C5-C12cycloalkyl; C2-C18alkyl which is interrupted by one or more O; SR4; OR5; or is a group of formula II or III R2, R21 and R3 independently of one another, are H or —Y-T as defined in claim 1, where T is a reactive group selected from OH, acryl- and methacryloxy and arylcarbonate groups, and further symbols are as defined in claim 1, are effective as crosslinking agents for polymeric networks, especially as in flexographic printing plates, coatings, and plastic containers or films. Further provided is a method of protecting the content of a clear or lightly colored plastic container or film against the deleterious effects of ultraviolet radiation, which method comprises permanently and covalently bonding one or more UV absorbing moieties of a durable s-triazine UV absorber via condensation to a suitable polymer component.

    Abstract translation: 通式I'的化合物，其中R 1是H，C 1 -C 12烷基; C5-C12环烷基; 被一个或多个O中断的C 2 -C 18烷基; SR4; OR5; 或者是式II或III中的R 2，R 21和R 3彼此独立的基团是如权利要求1所定义的H或-YT，其中T是选自OH，丙烯酰基和甲基丙烯酰氧基和芳基碳酸酯基的反应性基团， 符号如权利要求1中所定义，可用作聚合物网络的交联剂，特别是在柔性版印刷版，涂料和塑料容器或薄膜中。 进一步提供了一种保护透明或浅色塑料容器或薄膜的含量以抵抗紫外线辐射的有害影响的方法，该方法包括通过冷凝物永久地和共价键合耐久的三嗪UV吸收剂的一个或多个UV吸收部分 到合适的聚合物组分。

    락탐 제조 방법
    99.
    发明授权
    락탐 제조 방법 失效
    LACTAM生产方法

    公开(公告)号：KR100916735B1

    公开(公告)日：2009-09-14

    申请号：KR1020077019205

    申请日：2006-02-14

    Applicant: 로디아 쉬미

    Inventor： 르꽁뜨필리쁘

    IPC: C07D201/08 ,  C07D201/00

    CPC classification number: C07D201/08 ,  Y02P20/52

    Abstract: 본 발명은 락탐 제조 방법에 관한 것이다. 더욱 구체적으로는, 본 발명은 예를 들면 불포화 모노니트릴 화합물, 더욱 특히는 2-, 3- 또는 4-펜텐니트릴과 같은 펜텐니트릴 (이는 단독 또는 혼합물이고, 이하에서 혼합물에 대해서는 PN 으로, 그리고 2PN, 3PN 및 4PN 으로 각각 지칭함)을 원료로서 사용하여 수득된 알킬 시아노발레레이트로부터 락탐을 제조하는 방법에 관한 것이다. 본 발명의 방법은, 알킬아미노카프로에이트의 중간 분리 없어, 알킬 시아노발레레이트를 e-카프로락탐으로 수소화 및 고리화시키는 것을 포함한다.

    락탐 제조 방법
    100.
    发明公开
    락탐 제조 방법 失效
    LACTAM生产方法

    公开(公告)号：KR1020070096042A

    公开(公告)日：2007-10-01

    申请号：KR1020077019205

    申请日：2006-02-14

    Applicant: 로디아 쉬미

    Inventor： 르꽁뜨필리쁘

    IPC: C07D201/08 ,  C07D201/00

    CPC classification number: C07D201/08 ,  Y02P20/52

    Abstract: The invention relates to a lactam production method. More specifically, the invention relates to a method of producing lactams from alkyl cyanovalerate compounds obtained using, for example, unsaturated mononitrile compounds as raw materials and, more particularly, pentenenitriles such as 2-, 3-, 4-pentenenitriles taken alone or in a mixture and hereafter referred to as PN for the mixture and 2PN, 3PN and 4PN respectively. The inventive method comprises the hydrogenation and the cyclization of the alkyl cyanovalerate into e-caprolactam without the intermediate separation of the akylaminocaproate.

    Abstract translation: 本发明涉及内酰胺生产方法。 更具体地说，本发明涉及从使用例如不饱和单腈化合物作为原料得到的烷基氰基戊酸酯化合物制备内酰胺的方法，更具体地说，涉及单独使用的2-，3-，4-戊烯腈等的戊烯腈， 混合物，以下分别称为PN和2PN，3PN和4PN。 本发明的方法包括将氰基氰酸烷基酯氢化和环化成ε-己内酰胺而不中间分离烷基氨基己酸酯。

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