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1.发明申请Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof 有权二肽基肽酶IV抑制剂的生产方法和化合物及其中间体公开(公告)号：US20050090539A1
公开(公告)日：2005-04-28
申请号：US10716012
申请日：2003-11-18
Applicant: Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
Inventor： Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
IPC: A61K31/403 , A61K31/435 , C07C62/06 , C07C69/00 , C07C69/716 , C07C229/28 , C07C271/22 , C07D20060101 , C07D201/00 , C07D207/22 , C07D207/277 , C07D209/02 , C07D209/52 , C07D221/02
CPC classification number: C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
Abstract: Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
Abstract translation: 提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。
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公开(公告)号：US06828119B2
公开(公告)日：2004-12-07
申请号：US10017711
申请日：2001-12-14
Applicant: Ramesh Patel , David Brzozowski , Venkata Nanduri
Inventor： Ramesh Patel , David Brzozowski , Venkata Nanduri
IPC: C12P100
CPC classification number: C12P41/007 , C12P17/00 , C12P17/10 , C12P41/004
Abstract: Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC*(R)H—(CH2)n—O—C(═O)— where the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.
Abstract translation: 本发明提供了一种使由一组取代基保护的氢氧化物或胺脱保护的方法，所述取代基如下所述，所述方法包括：使被保护的氢氧化物或胺与有效除去保护基团的酶接触; 并回收胺。 还提供了分离产生有效去除保护基团的酶的细菌的方法，包括：在具有生长选择量的如上所述保护的胺化合物的培养基上生长未来的细菌; 并分离在所述培养基上生长的细菌。
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Patent Agency Ranking3.发明授权Method of chiral epoxidation of benzopyran or pyranopyridine derivatives using microorganisms 失效使用微生物手性环氧化苯并吡喃或吡喃并吡啶衍生物的方法
公开(公告)号：US5478734A
公开(公告)日：1995-12-26
申请号：US192918
申请日：1994-02-07
Applicant: Ramesh N. Patel , Amit Banerjee , Clyde McNamee , David Brzozowski , Laszlo J. Szarka
Inventor： Ramesh N. Patel , Amit Banerjee , Clyde McNamee , David Brzozowski , Laszlo J. Szarka
IPC: C07D311/22 , C07D311/70 , C07D493/04 , C12P17/18 , C12P41/00 , C12P17/06
CPC classification number: C07D493/04 , C07D311/22 , C07D311/70 , C12P17/18 , C12P17/181 , C12P41/004
Abstract: An enzymatic process for the preparation of chiral epoxides, monohydroxy or dihydroxy compounds of formula ##STR1## by the stereoselective epoxidation or hydroxylation of benzopyrans of formula ##STR2## or resolution of compounds of formula ##STR3## The compounds of formula I and II are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.
Abstract translation: 通过式III的苯并吡喃的立体选择性环氧化或羟基化或通式IIa的化合物的拆分来制备式I化合物的手性环氧化物，单羟基或二羟基化合物的酶促方法化合物 式I和II是可用于制备吡喃基氰胍衍生物的中间体。
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4.发明申请ENZYMATIC AMMONOLYSIS PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR DPP IV INHIBITORS 有权用于制备DPP IV抑制剂的中间体的酶促溶解方法公开(公告)号：US20070207527A1
公开(公告)日：2007-09-06
申请号：US11736786
申请日：2007-04-18
Applicant: Ramesh Patel , Ronald Hanson , Iqbal Gill , David Brzozowski , Paul Skonezny , Michael Politino , Jason Chen , Francisco Moris-Varas , Brenda White
Inventor： Ramesh Patel , Ronald Hanson , Iqbal Gill , David Brzozowski , Paul Skonezny , Michael Politino , Jason Chen , Francisco Moris-Varas , Brenda White
IPC: C12P13/24
CPC classification number: C07D207/22 , C07D209/52 , C07K5/06078 , C12P13/04 , C12P17/10 , C12P17/12
Abstract: An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process.
Abstract translation: 提供酶促氨解方法用于制备用于制备二肽基肽酶IV抑制剂的中间体，其中使用南极假丝酵母脂肪酶-B来催化氨解过程。
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5.发明授权Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof 失效稠合杂环琥珀酰亚胺化合物及其类似物的制备方法公开(公告)号：US06953679B2
公开(公告)日：2005-10-11
申请号：US10024878
申请日：2001-12-19
Applicant: Mark E. Salvati , Toomas Mitt , Ramesh N. Patel , Ronald L. Hanson , David Brzozowski , Animesh Goswami , Linda Nga Hoong Chu , Wen-sen Li , James H. Simpson , Michael J. Totleben , Weixuan He
Inventor： Mark E. Salvati , Toomas Mitt , Ramesh N. Patel , Ronald L. Hanson , David Brzozowski , Animesh Goswami , Linda Nga Hoong Chu , Wen-sen Li , James H. Simpson , Michael J. Totleben , Weixuan He
IPC: A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C12P17/10 , C12N1/00
CPC classification number: C07D487/18 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , A61K2300/00
Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
Abstract translation: 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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6.发明申请METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF 失效熔融杂环化合物化合物的制备方法及其模拟物公开(公告)号：US20050119228A1
公开(公告)日：2005-06-02
申请号：US10024878
申请日：2001-12-19
Applicant: Mark Salvati , Toomas Mitt , Ramesh Patel , Ronald Hanson , David Brzozowski , Animesh Goswami , Linda Chu , Wen-sen Li , James Simpson , Michael Totleben , Weixuan He
Inventor： Mark Salvati , Toomas Mitt , Ramesh Patel , Ronald Hanson , David Brzozowski , Animesh Goswami , Linda Chu , Wen-sen Li , James Simpson , Michael Totleben , Weixuan He
IPC: A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C07D487/14
CPC classification number: C07D487/18 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , A61K2300/00
Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
Abstract translation: 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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7.发明申请Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors 有权用于制备DPP IV抑制剂中间体的酶促氨解过程公开(公告)号：US20050256019A1
公开(公告)日：2005-11-17
申请号：US11119552
申请日：2005-05-02
Applicant: Ramesh Patel , Ronald Hanson , Iqbal Gill , David Brzozowski , Paul Skonezny , Michael Politino , Jason Chen , Francisco Moris-Varas , Brenda White
Inventor： Ramesh Patel , Ronald Hanson , Iqbal Gill , David Brzozowski , Paul Skonezny , Michael Politino , Jason Chen , Francisco Moris-Varas , Brenda White
IPC: C07D207/22 , C07D209/52 , C07K5/065 , C11D3/00 , C12P17/10
CPC classification number: C07D207/22 , C07D209/52 , C07K5/06078 , C12P13/04 , C12P17/10 , C12P17/12
Abstract: An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process.
Abstract translation: 提供酶促氨解方法用于制备用于制备二肽基肽酶IV抑制剂的中间体，其中使用南极假丝酵母脂肪酶-B来催化氨解过程。
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