公开(公告)号：US10386300B2

公开(公告)日：2019-08-20

申请号：US15384918

申请日：2016-12-20

Applicant: Verily Life Sciences LLC

Inventor： Cheng-Hsun Wu ,  Victor Marcel Acosta ,  Ian Peikon ,  Paul Lebel ,  Jerrod Joseph Schwartz

IPC: G01N21/64 ,  G06T7/90 ,  G02B21/16 ,  G02B21/36 ,  G02B26/08 ,  G02F1/29 ,  G01J3/02 ,  G01J3/08 ,  G01J3/14 ,  G01J3/18 ,  G01J3/28 ,  G01J3/32 ,  G01J3/44 ,  G02B5/18 ,  G01J3/12

Abstract: Methods are provided to identify spatially and spectrally multiplexed probes in a biological environment. Such probes are identified by the ordering and color of fluorophores of the probes. The devices and methods provided facilitate determination of the locations and colors of such fluorophores, such that a probe can be identified. In some embodiments, probes are identified by applying light from a target environment to a spatial light modulator that can be used to control the direction and magnitude of chromatic dispersion of the detected light; multiple images of the target, corresponding to multiple different spatial light modulator settings, can be deconvolved and used to determine the colors and locations of fluorophores. In some embodiments, light from a region of the target can be simultaneously imaged spatially and spectrally. Correlations between the spatial and spectral images over time can be used to determine the color of fluorophores in the target.

公开(公告)号：US10295470B2

公开(公告)日：2019-05-21

申请号：US15560256

申请日：2016-03-22

Applicant: JASCO Corporation

Inventor： Kento Aizawa ,  Tsutomu Inoue ,  Masateru Usuki

IPC: G01N21/65 ,  G01J3/08 ,  G01J3/44 ,  G02B21/00 ,  G01J3/06 ,  G01J3/28 ,  G01J3/02 ,  G01J3/10 ,  G01N21/64 ,  G01N21/59

Abstract: To provide a microspectroscope that can perform a wide range mapping measurement with high sensitivity, at high speed, and with high wavelength resolution.The Raman spectroscope comprises: a unit for linearly irradiating excitation light; a movable stage for a sample; an objective lens for focusing Raman light from the linear irradiation region; an incident slit provided at the imaging position of Raman light; a spectrometer for diffusing the passing light; a CCD detector for detecting Raman spectral image; and a control device for controlling the mapping measurement by synchronizing the movable stage and the CCD detector. The control device controls the movable stage to move in the direction orthogonal to the longitudinal direction of the linear irradiation light and obtain one average spectrum. At the same time, the control device is configured to perform the cycle of the CCD detector while the stage is moving to obtain one average spectrum of the moving region of the linear irradiation region in one light detection cycle.

公开(公告)号：US20110194117A1

公开(公告)日：2011-08-11

申请号：US13123683

申请日：2010-01-11

Applicant: Huikai Xie ,  Andrea Pais ,  Lei Wu ,  Sean Robert Samuelson ,  Shuguang Guo

Inventor： Huikai Xie ,  Andrea Pais ,  Lei Wu ,  Sean Robert Samuelson ,  Shuguang Guo

IPC: G01J3/45 ,  G01J3/08

CPC classification number: G01J3/4532 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/45

Abstract: Methods and designs for providing reduced sensitivity to mirror tilt in Fourier transform spectrometers are disclosed. According to an embodiment for two-directional tilt compensation, the FT spectrometer can include a beam splitter positioned to receive an incoming beam from a light source and split the incoming beam into a first sub-beam and a second sub-beam, a corner-cube retroreflector positioned to receive the first sub-beam from the beam splitter, a dual reflective mirror positioned to receive the first sub-beam from the corner-cube retroreflector at one surface and the second sub-beam at the other surface. An optical path delay can be created using a set of mirrors, tilting the beam splitter and/or a glass cube.

Abstract translation: 公开了在傅里叶变换光谱仪中提供对镜面倾斜的灵敏度降低的方法和设计。 根据用于双向倾斜补偿的实施例，FT光谱仪可以包括分束器，其被定位成接收来自光源的入射光束，并将入射光束分成第一子光束和第二子光束， 立方体后向反射器被定位成从分束器接收第一子光束;双反射镜，定位成在一个表面处接收来自角立方后视反射器的第一子光束，而在另一个表面处接收第二子光束。 可以使用一组反射镜，倾斜分束器和/或玻璃立方体来产生光路延迟。

公开(公告)号：US07508506B2

公开(公告)日：2009-03-24

申请号：US11865587

申请日：2007-10-01

Applicant: Sean M. Christian ,  Jess V. Ford ,  Mike Ponstingl ,  Anthony Johnson ,  Sven Kruger ,  Margaret C. Waid ,  Bryan Kasperski ,  Enrique Prati

Inventor： Sean M. Christian ,  Jess V. Ford ,  Mike Ponstingl ,  Anthony Johnson ,  Sven Kruger ,  Margaret C. Waid ,  Bryan Kasperski ,  Enrique Prati

IPC: G01J3/08 ,  G01J3/42

CPC classification number: G01J3/02 ,  E21B49/081 ,  E21B49/10 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0297 ,  G01J3/08 ,  G01J3/28 ,  G01J3/42 ,  G01J2003/1282 ,  G01J2003/1286 ,  G01N21/274

Abstract: An analysis system, tool, and method for performing downhole fluid analysis, such as within a wellbore. The analysis system, tool, and method provide for a tool including a spectroscope for use in downhole fluid analysis which utilizes an adaptive optical element such as a Micro Mirror Array (MMA) and two distinct light channels and detectors to provide real-time scaling or normalization.

Abstract translation: 用于进行井下流体分析的分析系统，工具和方法，例如在井筒内。 分析系统，工具和方法提供了一种包括用于井下流体分析的分光镜的工具，其利用诸如微镜阵列（MMA）的自适应光学元件和两个不同的光通道和检测器来提供实时缩放或 正常化。

公开(公告)号：US07440098B2

公开(公告)日：2008-10-21

申请号：US11696005

申请日：2007-04-03

Applicant: Sean M. Christian ,  Jess V. Ford ,  Mike Ponstingl ,  Sven Kruger ,  Margaret C. Waid ,  Bryan W. Kasperski ,  Enrique Prati

Inventor： Sean M. Christian ,  Jess V. Ford ,  Mike Ponstingl ,  Sven Kruger ,  Margaret C. Waid ,  Bryan W. Kasperski ,  Enrique Prati

IPC: G01J3/08 ,  G01J3/18 ,  G01J3/42

CPC classification number: G01J3/08 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0297 ,  G01J3/28 ,  G01J3/42 ,  G01J2003/1282 ,  G01J2003/1286 ,  G01N21/274

Abstract: A spectroscope designed to utilize an adaptive optical element such as a micro mirror array (MMA) and two distinct light channels and detectors. The devices can provide for real-time and near real-time scaling and normalization of signals.

Abstract translation: 设计用于利用诸如微镜阵列（MMA）和两个不同的光通道和检测器的自适应光学元件的分光镜。 这些设备可以提供信号的实时和近乎实时的缩放和归一化。

公开(公告)号：US07368292B2

公开(公告)日：2008-05-06

申请号：US11401791

申请日：2006-04-11

Applicant: Rolf E. Hummel ,  Ann Marie Fuller ,  Claus Schollhorn ,  Paul H. Holloway

Inventor： Rolf E. Hummel ,  Ann Marie Fuller ,  Claus Schollhorn ,  Paul H. Holloway

IPC: G01N33/22 ,  G01N21/55 ,  G01N21/33 ,  G01J1/32 ,  G01J1/42 ,  G01J3/08 ,  G01J3/42 ,  G01J3/433

CPC classification number: G01N21/31 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/55 ,  G01N33/227 ,  G01N2001/022 ,  G01N2021/1793 ,  G01N2021/3133 ,  Y10T436/170769 ,  Y10T436/173076

Abstract: A system and method for identifying explosive or other target materials includes the steps of irradiating a first location and a second location spaced apart from the first location from a sample suspected of including explosives with ultraviolet, visible or infrared light, measuring reflected light emanated from the first sample location (R1) and reflected light emanated from the second sample location (R2), and calculating a normalized difference in reflectivity (ΔR/ R), wherein R=(R1+R2)/2 is an average reflectivity. A differential reflection spectrum (DRS) is then generated for the sample where ΔR=R2−R1 is the difference of the reflectivities of the first and the second sample location. One or more explosives if present are identified in the sample based on comparing the DRS for said sample to at least one reference DRS.

Abstract translation: 用于识别爆炸物或其他目标材料的系统和方法包括以下步骤：将与第一位置隔开的第一位置和与怀疑包括具有紫外线，可见光或红外光的爆炸物的样品的第二位置照射，测量从 第一采样位置（R 1> 1）和从第二采样位置（R 2> 2发出）的反射光，并计算归一化反射率差（ΔR/ O OYYLE =“ 其中 R =（R 1 + R 2/2）/ 2是平均反射率。 然后为样品产生差分反射光谱（DRS），其中ΔR= R 2 -R 1 1是第一和第二样品位置的反射率的差。 基于将所述样品的DRS与至少一个参考DRS进行比较，在样品中鉴定存在的一种或多种爆炸物。

公开(公告)号：US06956648B2

公开(公告)日：2005-10-18

申请号：US10169032

申请日：2000-12-21

Applicant: Martin Loicht ,  Andreas Weingartner ,  Wendelin Weingartner ,  Nikolaus Fleischmann ,  Thomas Zipper ,  Bernhard Weingartner

Inventor： Martin Loicht ,  Andreas Weingartner ,  Wendelin Weingartner ,  Nikolaus Fleischmann ,  Thomas Zipper ,  Bernhard Weingartner

IPC: G01J3/08 ,  G01J3/02 ,  G01J3/42 ,  G01N21/27 ,  G01N21/3504 ,  G01N21/85

CPC classification number: G01J3/42 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0227 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/0256 ,  G01N21/8507 ,  G01N2021/3509

Abstract: Miniaturized spectrometer in the form of a probe for determining ingredients of a gaseous or liquid fluid with a light source and a spectrometer, at least one measurement beam, and at least one reference beam. Light from the light source is optionally fanned out and focused, by at least one optical lens, in an essentially parallel beam. At least one measurement beam is passed through a light transparent window from the probe into the fluid being investigated and through an additional light transparent window back in to the probe, and at least one reference beam is guided in the probe interior. A collecting optics device, comprising at least one lens, diverts the beams to the impingement point of the light guide or the inlet of the spectrometer, and a beam selector in the area of the collecting optics device passes through one of the partial beams and interrupts all the others.

Abstract translation: 用于利用光源和光谱仪，至少一个测量光束和至少一个参考光束来测定气体或液体流体的成分的探针形式的小型化光谱仪。 来自光源的光可选择地通过至少一个光学透镜扇出并聚焦在基本上平行的光束中。 至少一个测量光束从探针通过透光窗口进入正在研究的流体，并通过另外的透光窗口返回到探头中，并且至少一个参考光束在探头内部中被引导。 包括至少一个透镜的收集光学装置将光束转移到光导的入射点或光谱仪的入口，并且收集光学装置的区域中的光束选择器通过部分光束和中断之一 所有其他人

公开(公告)号：US06839134B2

公开(公告)日：2005-01-04

申请号：US10255623

申请日：2002-09-27

Applicant: Michihiro Saito ,  Satoshi Takahashi ,  Koichi Matsumoto

Inventor： Michihiro Saito ,  Satoshi Takahashi ,  Koichi Matsumoto

IPC: G01J3/08 ,  G01J3/44 ,  G01N21/25 ,  G01N21/64

CPC classification number: G01N21/6452 ,  G01J3/08 ,  G01J3/4406

Abstract: At the time of analytical measurement of a sample by the fluorescence measuring device or the phosphorescence measuring device, both the optical path of exciting light emitted from the light source to the sample and the optical path of fluorescence or phosphorescence emitted from the sample to the detection unit are shut off. Both are shut off by one chopper.

公开(公告)号：US5815263A

公开(公告)日：1998-09-29

申请号：US865868

申请日：1997-05-30

Applicant: Masumi Sakai

Inventor： Masumi Sakai

IPC: G01J3/08 ,  G01J3/42

CPC classification number: G01J3/08 ,  G01J3/42

Abstract: A double-beam spectrophotometer of the invention is provided with a sector mirror used at a luminous flux separating portion or at a luminous flux combining portion, and a DC brushless motor is used for actuating the sector mirror to rotate. Since the DC brushless motor is used, the sector mirror can be rotated at high speed with few noise. Also, the double-beam spectrophotometer can measure the change in the short period of time.

Abstract translation: 本发明的双光束分光光度计具有在光束分离部分或光束组合部分处使用的扇形镜，并且DC无刷电动机用于致动扇形镜转动。 由于使用了直流无刷电动机，扇形镜可以高速旋转，噪音小。 此外，双光束分光光度计可以测量短时间内的变化。

公开(公告)号：US5652654A

公开(公告)日：1997-07-29

申请号：US689391

申请日：1996-08-12

Applicant: George Asimopoulos

Inventor： George Asimopoulos

IPC: G01J3/08 ,  G01J3/28 ,  G01J3/42 ,  G01J3/18

CPC classification number: G01J3/2889 ,  G01J3/08 ,  G01J3/42 ,  G01J2003/2866

Abstract: A dual beam spectophotometer is described in which a beamsplitter is at least partially surrounded by a chopper, the combination of which provide sample and reference beams. An oscillating grating produces a monochromatic light beam scans a selected spectral range of wavelengths. The movement of a second chopper and of the oscillating grating is controlled to alternately pass sample and reference spectrums for detection by a detector and to block all radiation. Detected signals are processed for storage by suitable electronics and a computer. The electronics also control the motion of the oscillating grating and chopper. A set of beamsplitters with distinctly different sample-to-reference beam ratios are provided to add versatility to the spectrophotometer.

Abstract translation: 描述了一种双光束光谱仪，其中分束器至少部分地由斩波器包围，其组合提供了采样和参考光束。 振荡光栅产生单色光束扫描所选择的波长范围。 控制第二斩波器和振荡光栅的移动以交替地通过采样和参考光谱，以便由检测器检测并阻止所有辐射。 检测到的信号由适当的电子设备和计算机进行处理。 电子设备还可以控制振荡光栅和斩波器的运动。 提供了一组具有明显不同的样品与参比光束比的分光镜，以增加分光光度计的多功能性。