公开(公告)号：AU2019300987A1

公开(公告)日：2021-03-11

申请号：AU2019300987

申请日：2019-07-11

Applicant: STICHTING VUMC

Inventor： NIEUWENHUIJZEN JACOBUS ADRIANUS ,  STEENBERGEN RENSKE DANIËLA MARIA ,  BOSSCHIETER JUDITH

IPC: C12Q1/6886

Abstract: The invention relates to methods for detecting the presence of, or risk at, bladder cancer using novel DNA methylation markers for bladder cancer and to kits of parts useful in such methods.

公开(公告)号：AU2019270623A1

公开(公告)日：2020-12-03

申请号：AU2019270623

申请日：2019-05-15

Applicant: JANSSEN BIOTECH INC ,  STICHTING VUMC

Inventor： ADAMS HOMER ,  GAUDET FRANCOIS ,  FRERICHS KRIS ,  VAN DE DONK NIELS ,  VERKLEIJ CHRISTIE

IPC: A61K39/395 ,  A61K39/00 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30

Abstract: The present application relates to bispecific antibodies, either BCMA*CD3 or GRRC5D*CD3. The bispecific antibodies are to be used in the treatment of refractory cancers, especially after a previous treatment with an anti CD38-antibody.

公开(公告)号：UY38236A

公开(公告)日：2019-11-29

申请号：UY38236

申请日：2019-05-16

Applicant: JANSSEN BIOTECH INC ,  STICHTING VUMC

Inventor： GAUDET FRANCOIS ,  ADAMS HOMER ,  FRERICHS KRIS ,  NIELS VAN DE DONK ,  CHRISTIE C P M VERKLEIJ

IPC: A61P35/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/46

Abstract: Se describen combinaciones farmacéuticas que contienen el anticuerpo anti CD-38 asociado con el anticuerpo bioespecífico BCMAxCD3 o con el anticuerpo bioespecífico GPRC5DxCD3 o con el anticuerpo biespecífico CD19xCD3 o con el anticuerpo bioespecífico CD19xCD3, y métodos para tratar cánceres y potenciar la eficacia de terapéuticas de redireccionamiento de células T.

公开(公告)号：CA3100157A1

公开(公告)日：2019-11-21

申请号：CA3100157

申请日：2019-05-15

Applicant: JANSSEN BIOTECH INC ,  STICHTING VUMC

Inventor： ADAMS HOMER ,  GAUDET FRANCOIS ,  FRERICHS KRIS ,  VAN DE DONK NIELS ,  VERLEIJ CHRISTIE C P M

IPC: A61K39/395 ,  A61K35/17 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  C12Q1/68

Abstract: The disclosure provides methods of treating a cancer and/or killing tumor cells in a subject, comprising administering a therapeutically effective amount of an anti-CD38 antibody and a T cell redirecting therapeutic to the subject to treat the cancer. The disclosure provides a method of enhancing efficacy of a T cell redirecting therapeutic in a subject having a cancer, comprising administering to the subject an anti-CD38 antibody. The disclosure also provides a method of treating a multiple myeloma in a subject, comprising administering a therapeutically effective amount of a BCMAxCDS bispecific antibody and an anti-CD38 antibody to the subject to treat the multiple myeloma. The disclosure also provides a pharmaceutical combination comprising a GPRC5DxCD3 bispecific antibody. The disclosure also provides a kit comprising a pharmaceutical composition comprising a BCMAxCD3 bispecific antibody and an anti-CD38 antibody.

公开(公告)号：CA3062255A1

公开(公告)日：2018-11-08

申请号：CA3062255

申请日：2018-05-04

Applicant: STICHTING VUMC

Inventor： VAN DER KNAAP MARGO SIENTJE ,  HEINE VIVI MAJELLA ,  ABBINK GERTRUDE ELISE MARIA

IPC: A61K31/00 ,  A61K31/4168 ,  A61P25/28

Abstract: The invention relates to Guanabenz or an analogue thereof for use in the treatment and to methods of treatment of a subject that has vanishing white matter (VWM), comprising administering the compound Guanabenz or an analogue thereof to the subject in need thereof. Also provided are methods with which the success of a medical intervention in a subject with VWM can be determined. Such methods comprise quantifying the translocation of Bergmann glia into the molecular layer in the cerebellum in a suitable sample of the sub ject. The sample is typically a post mortem sample.

公开(公告)号：NL2017203B1

公开(公告)日：2018-01-30

申请号：NL2017203

申请日：2016-07-21

Applicant: STICHTING VUMC ,  OLIVIER PAUL PIETER TEMMERMAN

Inventor： OLIVIER PAUL PIETER TEMMERMAN ,  MICHA ILAN PAALMAN

IPC: A61B17/16 ,  A61B17/88

Abstract: Surgical instrument for removal of cured bone cement, such as used in orthopedic hip surgery, comprising a support rod or bar, and a breaking tool for the bone cement provided at an extremity of the support rod or bar, wherein the break- ing tool comprises an elongated nose and a relative to the nose shorter knife or chisel, wherein between the nose and the knife or chisel a room is provided which is arranged to receive part of the cured bone cement that is to be removed.

公开(公告)号：PL2717883T3

公开(公告)日：2017-07-31

申请号：PL11731142

申请日：2011-05-02

Applicant: STICHTING VUMC

Inventor： VAN NIEUW AMERONGEN GEERTEN P ,  VONK NOORDEGRAAF ANTON ,  AMAN JURJAN ,  VAN HINSBERGH VICTOR W M

IPC: C12N15/113 ,  A61K31/506 ,  A61K31/713 ,  C07K16/18

公开(公告)号：MX2016013332A

公开(公告)日：2017-05-01

申请号：MX2016013332

申请日：2015-04-10

Applicant: STICHTING VUMC

Inventor： JOHANNES JELLE VAN DER VLIET ,  RENÉE CORNELIA GERARDA DE BRUIN ,  TANJA DENISE DE GRUIJL ,  HENDRIK MARINUS WILLEM VERHEUL

IPC: C07K16/28

Abstract: La invención está en el campo de la medicina y se refiere a la inmunología, y se refiere en particular a moléculas de inmunoglobulina que se unen al receptor de célula T V?9Vd2 humanas; las moléculas de inmunoglobulina que se unen al receptor de célula T V?9Vd2 humanas son en particular para su uso en el tratamiento médico y/o útiles en pruebas con células T V?9Vd2 humanas, en donde la células T V?9Vd2 humanas pueden ser moduladas.

公开(公告)号：PT2717883T

公开(公告)日：2017-04-19

申请号：PT11731142

申请日：2011-05-02

Applicant: STICHTING VUMC

Inventor： GEERTEN P VAN NIEUW AMERONGEN ,  ANTON VONK NOORDEGRAAF ,  JURJAN AMAN ,  VICTOR W M VAN HINSBERGH

IPC: C12N15/113 ,  A61K31/506 ,  A61K31/713 ,  C07K16/18

公开(公告)号：AU2015252223A1

公开(公告)日：2016-11-24

申请号：AU2015252223

申请日：2015-04-21

Applicant: STICHTING VUMC ,  UNIV GRANADA

Inventor： PEGTEL DIRK MICHIEL ,  KOPPERS-LALIC DANIJELA ,  WURDINGER TOM ,  BIJNSDORP IRENE ,  HACKENBERG MICHAEL

IPC: C12Q1/68

Abstract: The present disclosure provides small ncRNAs as biomarkers for classifying the health status of an individual. The disclosure also provides screening methods for identifying ncRNA biomarkers.