公开(公告)号：US20240301083A1

公开(公告)日：2024-09-12

申请号：US18657180

申请日：2024-05-07

Applicant: Janssen Biotech, Inc. ,  Stichting VUmc

Inventor： Homer Adams ,  Francois Gaudet ,  Niels Van de Donk ,  Kris Frerichs ,  Christie Verkleij

IPC: C07K16/28 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K16/30 ,  C07K16/46

CPC classification number: C07K16/2896 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K16/2809 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/71

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics.

公开(公告)号：US12065500B2

公开(公告)日：2024-08-20

申请号：US16412701

申请日：2019-05-15

Applicant: Janssen Biotech, Inc. ,  Stichting VUmc

Inventor： Homer Adams ,  Francois Gaudet ,  Niels Van de Donk ,  Kris Frerichs ,  Christie Verkleij

IPC: C07K16/28 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K16/30 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K16/2809 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/71

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics.

公开(公告)号：US20200017564A1

公开(公告)日：2020-01-16

申请号：US16322786

申请日：2017-08-04

Applicant: STICHTING VUMC

Inventor： Arjan Willem GRIFFIOEN ,  Elisabeth Johanna Maria HUIJBERS ,  Patrycja NOWAK-SLIWINSKA

IPC: C07K14/47 ,  C07K14/245 ,  C12N15/62 ,  A61K39/00 ,  A61P35/00 ,  C07K16/18 ,  C12Q1/6886 ,  C07K14/78

Abstract: The invention is in the field of medicine. More specifically, it is in the field of diagnosing tumor angiogenesis status and in the field of medical treatment of a subject who is suffering, suspected to suffer, or might suffer from a tumor in the future. In particular, the invention relates to a fusion polypeptide comprising a foreign antigen and a self antigen, wherein said foreign antigen consists of a polypeptide comprising an amino acid sequence of at least 12-15 amino acid residues, 12-24% of which residues are hydrophilic, bulky amino acid residues selected from the group consisting of histidine, glutamate, arginine, glutamine, aspartic acid and/or lysine.

公开(公告)号：US20170051359A1

公开(公告)日：2017-02-23

申请号：US15308328

申请日：2015-04-21

Applicant: Stichting VUmc ,  Universidad de Granada

Inventor： Dirk Michiel Pegtel ,  Danijela Koppers-Lalic ,  Tom Wurdinger ,  Irene Bijnsdorp ,  Michael Hackenberg

IPC: C12Q1/68 ,  A61K38/14 ,  A61K31/7048 ,  A61K31/573 ,  A61K31/675 ,  A61K31/475 ,  A61K31/166 ,  A61K35/545 ,  A61K31/704

CPC classification number: C12Q1/6886 ,  A61K31/166 ,  A61K31/475 ,  A61K31/573 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7048 ,  A61K35/545 ,  A61K38/14 ,  C12Q1/6809 ,  C12Q2600/118 ,  C12Q2600/166 ,  C12Q2600/178 ,  C12Q2525/207 ,  C12Q2535/122 ,  C12Q2537/165 ,  C12Q2545/101

Abstract: Disclosed are small ncRNAs that may be used as biomarkers for classifying the health status of an individual. The disclosure also provides screening methods for identifying ncRNA biomarkers.

Abstract translation: 公开了可用作生物标志物的小型ncRNA，用于分类个体的健康状况。 本公开还提供用于鉴定ncRNA生物标志物的筛选方法。

公开(公告)号：US12012461B2

公开(公告)日：2024-06-18

申请号：US16412831

申请日：2019-05-15

Applicant: Janssen Biotech, Inc. ,  Stichting VUmc

Inventor： Homer Adams ,  Francois Gaudet ,  Niels Van de Donk ,  Kris Frerichs ,  Christie Verkleij

IPC: A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C07K16/2809 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/71

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics.

公开(公告)号：US11795202B2

公开(公告)日：2023-10-24

申请号：US16322786

申请日：2017-08-04

Applicant: STICHTING VUMC

Inventor： Arjan Willem Griffioen ,  Elisabeth Johanna Maria Huijbers ,  Patrycja Nowak-Sliwinska

IPC: A61K39/00 ,  C07K14/47 ,  A61P35/00 ,  C07K14/245 ,  C07K14/78 ,  C07K16/18 ,  C12N15/62 ,  C12Q1/6886

CPC classification number: C07K14/4748 ,  A61K39/0011 ,  A61P35/00 ,  C07K14/245 ,  C07K14/78 ,  C07K16/18 ,  C12N15/62 ,  C12Q1/6886 ,  A61K2039/55566 ,  A61K2039/585 ,  A61K2039/6068 ,  C07K2319/21 ,  C07K2319/35 ,  C12Q2600/106 ,  C12Q2600/112

Abstract: The invention is in the field of medicine. More specifically, it is in the field of diagnosing tumor angiogenesis status and in the field of medical treatment of a subject who is suffering, suspected to suffer, or might suffer from a tumor in the future. In particular, the invention relates to a fusion polypeptide comprising a foreign antigen and a self antigen, wherein said foreign antigen consists of a polypeptide comprising an amino acid sequence of at least 12-15 amino acid residues, 12-24% of which residues are hydrophilic, bulky amino acid residues selected from the group consisting of histidine, glutamate, arginine, glutamine, aspartic acid and/or lysine.

公开(公告)号：US10813548B2

公开(公告)日：2020-10-27

申请号：US16070042

申请日：2017-01-11

Applicant: Stichting VUmc

Inventor： Bob Wilhelm van Dijk

IPC: A61B3/08 ,  A61B3/00 ,  A61B3/11 ,  A61B3/113

Abstract: A method, system and computer readable medium for determining a strabismus angle of the eyes of an individual by: positioning the individual with his or her eyes in front of an eye tracker device and in front of a screen at a viewing distance; displaying a small image element on the screen; measuring a position and line of sight of the eyes of the individual with the eye tracker device while the individual is focussing on the small image element; forwarding the measured position and line of sight of the eyes from the eye tracker device to a computer system; and, calculating the strabismus angle between the eyes by calculating the difference in line of sight of the left and right eyes of the individual.

公开(公告)号：US11504415B2

公开(公告)日：2022-11-22

申请号：US16095273

申请日：2017-04-21

Applicant: Stichting VUmc

Inventor： Walter Joseph Paulus

IPC: A61K38/17 ,  A61K31/121

Abstract: The treatment of diastolic dysfunction in a subject and, in particular, compositions for use and methods in treating diastolic dysfunction are disclosed. In one aspect, the disclosure provides a composition for use comprising a therapeutically effective amount of a substance that increases the level and/or activity of a crystalline protein in cardiomyocytes of the subject. In particular, the composition for use according to the disclosure comprises a therapeutically effective amount of the alpha B crystalline protein. It was found that the composition for use is capable of treating diastolic dysfunction and diastolic heart disease in subjects with failing hearts that have a higher cardiomyocyte stiffness than controls. Particularly, addition of alpha B crystalline reduced the higher stiffness of failing cardiomyocytes to the level observed in control cardiomyocytes.

公开(公告)号：US20220196683A1

公开(公告)日：2022-06-23

申请号：US17599316

申请日：2020-03-27

Applicant: Stichting VUmc

Inventor： Betty Marije TIJMS ,  Pieter Jelle VISSER ,  Kaj Ingemar BLENNOW ,  John Henrik ZETTERBERG ,  Per Johan GOBOM

IPC: G01N33/68 ,  C07K16/18

Abstract: The invention relates to method for typing a sample of an individual suffering from, or is suspected to suffer from, a progressive neurodegenerative disease. The invention further relates to methods for assigning a treatment of the individual, based on said typing.

公开(公告)号：US20210172029A1

公开(公告)日：2021-06-10

申请号：US17258302

申请日：2019-07-11

Applicant: Stichting VUmc

Inventor： Jacobus Adrianus Nieuwenhuijzen ,  Renske Daniëla Maria Steenbergen ,  Judith Bosschiether

IPC: C12Q1/6886

Abstract: The invention relates to methods for detecting the presence of, or risk at, bladder cancer using novel DNA methylation markers for bladder cancer and to kits of parts useful in such methods.