公开(公告)号：WO2005109324A1

公开(公告)日：2005-11-17

申请号：PCT/EP2005/051803

申请日：2005-04-22

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  IBM UNITED KINGDOM LIMITED ,  ASCHENBRENNER, Jean, Margaret ,  HOHENSEE, Reinhard, Heinrich ,  QIAO, Yue ,  RIJAVEC, Nenad ,  STONE, David, Earl

Inventor： ASCHENBRENNER, Jean, Margaret ,  HOHENSEE, Reinhard, Heinrich ,  QIAO, Yue ,  RIJAVEC, Nenad ,  STONE, David, Earl

IPC: G06K15/00

CPC classification number: G06K15/02 ,  G06K2215/0094 ,  H04N1/603

Abstract: The Management of color presented at end point devices such as a display or printer is based on the implementation of a Color Management Resource (CR). A CMR is an architected resource stored accessibly to a print server or other processor that is used to carry all of the color management information required to render a print file, document, page, or data object.

Abstract translation: 终端设备（如显示器或打印机）上显示的颜色管理基于颜色管理资源（CR）的实现。 CMR是存储在打印服务器或其他处理器中的架构资源，其用于承载呈现打印文件，文档，页面或数据对象所需的所有颜色管理信息。

公开(公告)号：WO2005088470A2

公开(公告)日：2005-09-22

申请号：PCT/EP2005/051091

申请日：2005-03-10

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  IBM UNITED KINGDOM LIMITED ,  HOHENSEE, Reinhard Heinrich ,  LUEBBE, Terry Scott ,  MADER, Eric Richard ,  STONE, David ,  UMAMAHESWARAN, Vettakkorumakankavu ,  VARGA, John Thomas

Inventor： HOHENSEE, Reinhard Heinrich ,  LUEBBE, Terry Scott ,  MADER, Eric Richard ,  STONE, David ,  UMAMAHESWARAN, Vettakkorumakankavu ,  VARGA, John Thomas

IPC: G06F17/27

CPC classification number: G06F17/2223 ,  G06F17/214

Abstract: Systems and methods of identifying and processing complex text are provided. If a pre­sentation data stream contains a complex text string, a preselected control in the presentation data stream is inserted before the complex text string. A first parameter has a value indicating a control type for controlling processing of complex text, and a second parameter takes one or more values for enabling and disabling the processing of complex text. In processing complex text, responsive to a first predetermined type of control in a presentation data stream, if the first type of complex text processing is enabled, this processing is applied to a complex text string succeeding the first predetermined type of control in the presentation data stream. The first pre­determined type of control includes a first parameter represented by a corresponding value for controlling the first type of complex text processing.

Abstract translation: 提供了识别和处理复杂文本的系统和方法。 如果呈现数据流包含复杂文本串，则在复合文本字符串之前插入呈现数据流中的预先选择的控件。 第一参数具有指示用于控制复杂文本的处理的控制类型的值，第二参数采用一个或多个值来启用和禁用复杂文本的处理。 在处理复杂文本时，响应于演示数据流中的第一预定类型的控制，如果启用了第一类型的复杂文本处理，则该处理被应用于呈现数据中的第一预定类型的控制之后的复合文本串 流。 第一预定类型的控制包括由用于控制第一类型的复杂文本处理的对应值表示的第一参数。

公开(公告)号：WO2005051995A3

公开(公告)日：2005-06-09

申请号：PCT/US2004/038870

申请日：2004-11-19

Applicant: CURAGEN CORPORATION ,  STONE, David, J. ,  GUNTHER, Erik

Inventor： STONE, David, J. ,  GUNTHER, Erik

IPC: C07K14/705

Abstract: The present invention relates generally to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of a novel isoform of the Advanced Glycosylation End product-specific Receptor (RAGE), and its fragments, derivatives, variants, homologs, analogs, or a combination thereof.

公开(公告)号：WO2005051995A2

公开(公告)日：2005-06-09

申请号：PCT/US2004038870

申请日：2004-11-19

Applicant: CURAGEN CORP ,  STONE DAVID J ,  GUNTHER ERIK

Inventor： STONE DAVID J ,  GUNTHER ERIK

IPC: C07K14/705 ,  G01N33/566 ,  C07K14/70

CPC classification number: C07K14/70503

Abstract: The present invention relates generally to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of a novel isoform of the Advanced Glycosylation End product-specific Receptor (RAGE), and its fragments, derivatives, variants, homologs, analogs, or a combination thereof.

Abstract translation: 本发明一般涉及核酸，蛋白质和抗体。 本发明更具体地涉及高级糖基化终产物特异性受体（RAGE）的新型同种型的核酸分子，蛋白质和抗体及其片段，衍生物，变体，同系物，类似物或其组合。

公开(公告)号：WO2005036857A1

公开(公告)日：2005-04-21

申请号：PCT/US2004/033333

申请日：2004-10-08

Applicant: CITRIX SYSTEMS, INC. ,  PANASYUK, Anatoliy ,  KRAMER, Andre ,  PEDERSEN, Bradley, Jay ,  STONE, David, Sean ,  TREDER, Terry

Inventor： PANASYUK, Anatoliy ,  KRAMER, Andre ,  PEDERSEN, Bradley, Jay ,  STONE, David, Sean ,  TREDER, Terry

IPC: H04L29/06

CPC classification number: H04L63/0209 ,  G06F21/31 ,  H04L12/4633 ,  H04L63/0272 ,  H04L63/0281 ,  H04L63/0428 ,  H04L63/062 ,  H04L63/08 ,  H04L63/0807 ,  H04L63/166 ,  H04L67/14 ,  H04L69/329

Abstract: The invention relates to methods and systems for reconnecting a client and providing user authentication across a reliable and persistent communication session. A first protocol that encapsulates a plurality of secondary protocols is used to communicate over a network. A first protocol service, using the first protocol, provides session persistence and a reliable connection between a client and a host service. When there is a disruption in the network connection between a client and a host service, the connection is reestablished and the user re-authenticated to the host service without the user re-entering his or her authentication credentials or without the user re-establishing the user session with the host service.

Abstract translation: 本发明涉及用于重新连接客户端并在可靠和持续的通信会话中提供用户认证的方法和系统。 封装多个辅助协议的第一协议被用于通过网络进行通信。 使用第一协议的第一协议服务提供会话持久性和客户端与主机服务之间的可靠连接。 当客户机和主机服务之间的网络连接中断时，重新建立连接，并且用户重新认证到主机服务，而不用户重新输入他或她的认证凭证，或者没有用户重新建立 用户会话与主机服务。

公开(公告)号：WO2003102159A3

公开(公告)日：2003-12-11

申请号：PCT/US2003/017573

申请日：2003-06-04

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BAUMGARTNER, Jason, C. ,  BERGHS, Constance ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CATTERTON, Elina ,  DHANABAL, Mohanraj ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  ETTENBERG, Seth ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUNTHER, Erik ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  HERRMANN, John, L. ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LAROCHELLE, William, J. ,  LI, Li ,  LIANG, Hongping ,  LOW, Kenneth ,  MACDOUGALL, John, R. ,  MACLACHLAN, Timothy ,  MALYANKAR, Uriel, M. ,  MCQUEENEY, Kelly ,  MEZICK, Amanda, J. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  QIAN, Xiaozhong ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  SUKUMARAN, Sujatha ,  SZEKERES, Edward, S., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  WOLENC, Adam, R. ,  ZHONG, Mei ,  ZHONG, Haihong

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BAUMGARTNER, Jason, C. ,  BERGHS, Constance ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CATTERTON, Elina ,  DHANABAL, Mohanraj ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  ETTENBERG, Seth ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUNTHER, Erik ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  HERRMANN, John, L. ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LAROCHELLE, William, J. ,  LI, Li ,  LIANG, Hongping ,  LOW, Kenneth ,  MACDOUGALL, John, R. ,  MACLACHLAN, Timothy ,  MALYANKAR, Uriel, M. ,  MCQUEENEY, Kelly ,  MEZICK, Amanda, J. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  QIAN, Xiaozhong ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  SUKUMARAN, Sujatha ,  SZEKERES, Edward, S., Jr. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  WOLENC, Adam, R. ,  ZHONG, Mei ,  ZHONG, Haihong

IPC: C12Q1/68

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2003085124A3

公开(公告)日：2003-10-16

申请号：PCT/US2003/009775

申请日：2003-04-01

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P. II ,  BENTO, Patricia ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CRABTREE-BOKOR, Julie, R. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  FERNANDES, Elma, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUNTHER, Erik ,  GUSEV, Vladimir, Y. ,  HEYES, Melvyn, P. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, D. ,  SMITHSON, Glennda ,  STONE, David, J. ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z.

Inventor： ALSOBROOK, John, P. II ,  BENTO, Patricia ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CRABTREE-BOKOR, Julie, R. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  FERNANDES, Elma, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUNTHER, Erik ,  GUSEV, Vladimir, Y. ,  HEYES, Melvyn, P. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, D. ,  SMITHSON, Glennda ,  STONE, David, J. ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z.

IPC: C07K14/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2003083046A3

公开(公告)日：2003-10-09

申请号：PCT/US2003/010142

申请日：2003-04-01

Applicant: CURAGEN CORPORATION ,  ANDERSON, David, W. ,  BENTO, Patricia ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  FURTAK, Katarzyna ,  GORMAN, Linda ,  GOULD-ROTHBERG, Bonnie, E. ,  GUNTHER, Erik ,  HEYES, Melvyn, P. ,  LI, Li ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  ZHONG, Mei ,  MALYANKAR, Uriel, M. ,  EDINGER, Shlomit, R. ,  PATTURAJAN, Meera ,  ROTHENBERG, Mark, E. ,  SMITHSON, Glennda

Inventor： ANDERSON, David, W. ,  BENTO, Patricia ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  FURTAK, Katarzyna ,  GORMAN, Linda ,  GOULD-ROTHBERG, Bonnie, E. ,  GUNTHER, Erik ,  HEYES, Melvyn, P. ,  LI, Li ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  ZHONG, Mei ,  MALYANKAR, Uriel, M. ,  EDINGER, Shlomit, R. ,  PATTURAJAN, Meera ,  ROTHENBERG, Mark, E. ,  SMITHSON, Glennda

IPC: A61K38/00

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO0224733A3

公开(公告)日：2003-07-03

申请号：PCT/US0129115

申请日：2001-09-17

Applicant: CURAGEN CORP ,  MISHRA VISHNU S ,  SPYTEK KIMBERLY ANN ,  TAUPIER RAYMOND J JR ,  VERNET CORINE A M ,  COLMAN STEVEN D ,  GORMAN LINDA ,  TCHERNEV VELIZAR T ,  MALYANKAR URIEL M ,  SHENOY SURESH ,  PADIGARU MURALIDHARA ,  PATTURAJAN MEERA ,  BURGESS CATHERINE E ,  SMITHSON GLENNDA ,  MILLET ISABELLE ,  PEYMAN JOHN A ,  STONE DAVID ,  GUNTHER ERIK ,  ELLERMAN KAREN

Inventor： MISHRA VISHNU S ,  SPYTEK KIMBERLY ANN ,  TAUPIER RAYMOND J JR ,  VERNET CORINE A M ,  COLMAN STEVEN D ,  GORMAN LINDA ,  TCHERNEV VELIZAR T ,  MALYANKAR URIEL M ,  SHENOY SURESH ,  PADIGARU MURALIDHARA ,  PATTURAJAN MEERA ,  BURGESS CATHERINE E ,  SMITHSON GLENNDA ,  MILLET ISABELLE ,  PEYMAN JOHN A ,  STONE DAVID ,  GUNTHER ERIK ,  ELLERMAN KAREN

IPC: G01N33/50 ,  A61B10/00 ,  A61B10/02 ,  A61B17/00 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/54 ,  C07K14/705 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/24 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  A61K31/7088 ,  A61K38/17 ,  A61K38/19 ,  A61K38/44 ,  A61K39/00 ,  C07K16/24 ,  C07K16/28 ,  C07K16/40 ,  C12N9/02 ,  C12N15/11 ,  C12N15/53 ,  C12N15/62 ,  G01N33/68 ,  A61K67/027 ,  C07K16/72

CPC classification number: A61B10/0275 ,  A61B2010/0208 ,  A61B2017/00398 ,  C07K14/475 ,  C07K14/5425 ,  C07K14/705 ,  C07K14/70571

Abstract: Disclosed herein are nucleic acid sequences that encode Wnt, zinc transporter, mitsugumin29, slit-3, LRR/GPCR, major histocompatibility complex enhancer protein MAD3, interleukin 9, 5-hydroxytryptamine receptor, and thioredoxin related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码Wnt，锌转运蛋白，大霉素29，切口-3，LRR / GPCR，主要组织相容性复合物增强子蛋白MAD3，白细胞介素9,5-羟基色胺受体和硫氧还蛋白相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003040329A2

公开(公告)日：2003-05-15

申请号：PCT/US2002/035535

申请日：2002-11-05

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHANT, John, S. ,  CHAPOVAL, Andrei ,  CHAUDHURI, Amitabha ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GUO, Xiaojia ,  JI, Weizhen ,  KHRAMTSOV, Nikolai, V. ,  LEITE, Mario, W. ,  LI, Li ,  MEZES, Peter, S. ,  MILLET, Isabelle ,  OOI, Chean, Eng ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E.A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  QUINN SENGER, Kerry, E. ,  SMITHSON, Glennda ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TWOMLOW, Nancy ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CHANT, John, S. ,  CHAPOVAL, Andrei ,  CHAUDHURI, Amitabha ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GUO, Xiaojia ,  JI, Weizhen ,  KHRAMTSOV, Nikolai, V. ,  LEITE, Mario, W. ,  LI, Li ,  MEZES, Peter, S. ,  MILLET, Isabelle ,  OOI, Chean, Eng ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E.A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  QUINN SENGER, Kerry, E. ,  SMITHSON, Glennda ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TWOMLOW, Nancy ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

IPC: C12N

CPC classification number: C12N9/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.