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公开(公告)号：GB9406800D0
公开(公告)日：1994-05-25
申请号：GB9406800
申请日：1994-04-06
Applicant: STONE DAVID J , STONE LESLEY J
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公开(公告)号：GB9307262D0
公开(公告)日：1993-06-02
申请号：GB9307262
申请日：1993-04-07
Applicant: STONE DAVID J , STONE LESLEY J
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Patent Agency Ranking
公开(公告)号：WO2013066764A3
公开(公告)日：2014-08-21
申请号：PCT/US2012062218
申请日：2012-10-26
Applicant: MERCK SHARP & DOHME , LOBODA ANDREY , NEBOZHYN MICHAEL , PODTELEZHNIKOV ALEXEI , STONE DAVID J , TANIS KEITH , RAY WILLIAM J
Inventor： LOBODA ANDREY , NEBOZHYN MICHAEL , PODTELEZHNIKOV ALEXEI , STONE DAVID J , TANIS KEITH , RAY WILLIAM J
CPC classification number: C12Q1/6883 , A01K67/0275 , C12Q2600/158 , G01N33/6896
Abstract: Methods, biomarkers, and expression signatures are disclosed for assessing the disease progression of Alzheimer's disease (AD). In one embodiment, BioAge (biological age), NdStress (neurodegenerative stress), Alz (Alzheimer), and Inflame (inflammation) are used as biomarkers of AD progression. In another aspect, the invention comprises a gene signature for evaluating disease progression. In still another embodiment, methods for evaluating disease progression are provided. In yet another embodiment, the invention can be used to identify animal models for use in the development and evaluation of therapeutics for the treatment of AD.
Abstract translation: 公开了评估阿尔茨海默氏病（AD）疾病进展的方法，生物标志物和表达特征。 在一个实施方案中，使用BioAge（生物学年龄），NdStress（神经变性应激），Alz（阿尔茨海默）和Inflame（炎症））作为AD进展的生物标志物。 另一方面，本发明包括用于评估疾病进展的基因特征。 在另一个实施方案中，提供了评估疾病进展的方法。 在另一个实施方案中，本发明可用于鉴定用于开发和评估用于治疗AD的治疗剂的动物模型。
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7.发明申请METHOD FOR IDENTIFYING MODULATORS OF RUFY2 USEFUL FOR TREATING ALZHEIMER'S DISEASE 审中-公开鉴定用于治疗阿尔茨海默病的RUFY2调节剂的方法
公开(公告)号：WO2007002482A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024612
申请日：2006-06-23
Applicant: MERCK & CO., INC. , MAJERCAK, John M. , RAY, William, J. , STONE, David, J.
Inventor： MAJERCAK, John M. , RAY, William, J. , STONE, David, J.
IPC: C07H21/04 , C07K1/00 , C07K14/00 , C07K17/00 , A61K47/00 , A61K38/00 , A61K49/00 , A61K39/00 , A61K39/38 , A01N37/18 , G01N33/567
CPC classification number: G01N33/6896 , A61K38/00 , A61K47/646 , C07K14/47 , G01N33/5023 , G01N33/5038 , G01N2333/4709 , G01N2500/10 , G01N2800/2821
Abstract: Compositions and methods for identifying modulators of RUFY2 are described. The methods are particularly useful for identifying analytes that antagonize RUFY2’s effect on processing of amyloid precursor protein to Aβ peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.
Abstract translation: 描述了用于识别RUFY2的调节剂的组合物和方法。 该方法特别适用于鉴定拮抗RUFY2对淀粉样蛋白前体蛋白加工成Aβ肽的影响的分析物，因此可用于鉴定可用于治疗阿尔茨海默病的分析物。
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公开(公告)号：WO03076584A8
公开(公告)日：2004-05-21
申请号：PCT/US0306951
申请日：2003-03-06
Applicant: CURAGEN CORP , ALSOBROOK JOHN P II , BURGESS CATHERINE E , EDINGER SHLOMIT R , GERLACH VALERIE L , JI WEIZHEN , KEKUDA RAMESH , LI LI , MACDOUGALL JOHN R , MILLER CHARLES E , MILLET ISABELLE , PATTURAJAN MEERA , PENA CAROL E A , RIEGER DANIEL K , SCIORE PAUL , SHENOY SURESH G , SMITHSON GLENNDA , SPYTEK KIMBERLY A , STONE DAVID J , VOSS EDWARD Z , ZHONG MEI
Inventor： ALSOBROOK JOHN P II , BURGESS CATHERINE E , EDINGER SHLOMIT R , GERLACH VALERIE L , JI WEIZHEN , KEKUDA RAMESH , LI LI , MACDOUGALL JOHN R , MILLER CHARLES E , MILLET ISABELLE , PATTURAJAN MEERA , PENA CAROL E A , RIEGER DANIEL K , SCIORE PAUL , SHENOY SURESH G , SMITHSON GLENNDA , SPYTEK KIMBERLY A , STONE DAVID J , VOSS EDWARD Z , ZHONG MEI
Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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9.发明申请
公开(公告)号：WO2003066881A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003403
申请日：2003-02-03
Applicant: CURAGEN CORPORATION , ANDERSON, David, W. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , GORMAN, Linda , JI, Weizhen , KEKUDA, Ramesh , LI, Li , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , STONE, David, J. , TAUPIER, Raymond, J., Jr.
Inventor： ANDERSON, David, W. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , GORMAN, Linda , JI, Weizhen , KEKUDA, Ramesh , LI, Li , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , STONE, David, J. , TAUPIER, Raymond, J., Jr.
IPC: C12Q
CPC classification number: C07K14/47
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Abstract translation: 本文公开了编码新多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及对多肽特异的新多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明进一步公开了诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。
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公开(公告)号：WO2003057854A3
公开(公告)日：2003-07-17
申请号：PCT/US2003/000253
申请日：2003-01-06
Applicant: CURAGEN CORPORATION , ANDERSON, David, W. , BALLINGER, Robert, A. , BAUMGARTNER, Jason, C. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CHANT, John, S. , BERGHS, Constance , GANGOLLI, Esha, A. , EDINGER, Shlomit, R. , ELLERMAN, Karen , FURTAK, Katarzyna , GERLACH, Valerie, L. , GILBERT, Jennifer, A. , GUNTHER, Erik , GORMAN, Linda , GUO, Xiaojia , JI, Weizhen , LI, Li , LIU, Xiaohong , MILLER, Charles, E. , MILLET, Isabelle , PADIGARU, Muralidhara , PATTURAJAN, Meera , RASTELLI, Luca , MACDOUGALL, John, R. , MISHRA, Vishnu, S. , PENA, Carol, E, A. , SPADERNA, Steven, K. , SHIMKETS, Richard, A. , SMITHSON, Glennda , SPYTEK, Kimberly, A. , STONE, David, J. , SHENOY, Suresh, G. , ORT, Tatiana. , TAUPIER, Raymond, J, Jr. , TCHERNEV, Velizar, T. , VERNET, Corine, A, M. , WOLENC, Adam, R. , ZERHUSEN, Bryan, D. , ZHONG, Mei
Inventor： ANDERSON, David, W. , BALLINGER, Robert, A. , BAUMGARTNER, Jason, C. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CHANT, John, S. , BERGHS, Constance , GANGOLLI, Esha, A. , EDINGER, Shlomit, R. , ELLERMAN, Karen , FURTAK, Katarzyna , GERLACH, Valerie, L. , GILBERT, Jennifer, A. , GUNTHER, Erik , GORMAN, Linda , GUO, Xiaojia , JI, Weizhen , LI, Li , LIU, Xiaohong , MILLER, Charles, E. , MILLET, Isabelle , PADIGARU, Muralidhara , PATTURAJAN, Meera , RASTELLI, Luca , MACDOUGALL, John, R. , MISHRA, Vishnu, S. , PENA, Carol, E, A. , SPADERNA, Steven, K. , SHIMKETS, Richard, A. , SMITHSON, Glennda , SPYTEK, Kimberly, A. , STONE, David, J. , SHENOY, Suresh, G. , ORT, Tatiana. , TAUPIER, Raymond, J, Jr. , TCHERNEV, Velizar, T. , VERNET, Corine, A, M. , WOLENC, Adam, R. , ZERHUSEN, Bryan, D. , ZHONG, Mei
IPC: C07K1/00
Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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