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公开(公告)号：KR1020080027526A
公开(公告)日：2008-03-28
申请号：KR1020060092676
申请日：2006-09-25
Applicant: (주)아모레퍼시픽
IPC: A61K31/506 , A61K31/19 , A61P17/14
CPC classification number: A61K8/4953 , A61K8/34 , A61K8/92 , A61Q7/00 , Y10S514/88 , Y10S514/969
Abstract: A composition comprising minoxidil, tretinoin(all-trans retinoic acid), a solvent and glycerine is provided to promote permeation of the minoxidil without stimulus of the tretinoin, thereby inducing hair growth and alleviating alopecia. An external composition for preventing hair loss and promoting hair growth comprises 0.5-7.5 weight/volume% of minoxidil as a hair growth ingredient, 0.007-0.015 weight/volume% of tretinoin, 72-83 weight/volume% of ethanol, and 15-20 weight/volume% of glycerine.
Abstract translation: 提供包含米诺地尔，维A酸（全反式视黄酸），溶剂和甘油的组合物，以促进米诺地尔的渗透，而不刺激维甲酸，从而诱导毛发生长和减轻脱发。 用于防止脱发和促进毛发生长的外用组合物包含0.5-7.5重量/体积％的作为毛发生长成分的米诺地尔，0.007-0.015重量/体积％的维甲酸，72-83重量/体积％的乙醇和15- 20重量/体积％的甘油。
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公开(公告)号：KR100803577B1
公开(公告)日：2008-02-15
申请号：KR1020050115649
申请日：2005-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/498 , A61K8/602 , A61K2800/522 , A61Q19/02 , A61Q19/08
Abstract: 본 발명은 이카린의 가수분해물을 함유하는 화장료용 조성물에 관한 것으로, 보다 구체적으로는 이카린의 가수분해물인 이카리틴, 이카리시드 I 및 이카리시드 II를 함유하는 화장료에 관한 것이고, 상기 이카린(icariin)의 가수분해물은 (a) 식물로부터 물 또는 유기용매를 이용하여 이카린을 함유하는 식물 추출물을 수득하는 단계; 및 (b) 상기 수득된 식물 추출물을 산, 염기, 효소 또는 상기 효소를 생산하는 미생물을 이용하여 가수분해하는 단계를 포함하는 방법에 의해 제조될 수 있다.
본 발명에 따른 화장료용 조성물은 항산화, 항노화, 미백 또는 주름 개선용으로 적용될 수 있다.
에피메디움, 이카리틴, 이카리시드 I, 이카리시드 II, 이카린, 항산화, 미백, 주름 개선, 항노화, 화장료-
103.发明授权엘라스테아제 저해 효과를 갖는 3,5-디히드록시벤조산유도체 화합물과 그 제조방법 및 이를 함유하는 항노화화장료 조성물 有权,5-라스테아제저해효과를갖갖갖는,5- ,5- 3 3 3 3 3 3 3 3 3 3 3 3
公开(公告)号：KR100726280B1
公开(公告)日：2007-06-11
申请号：KR1020060035603
申请日：2006-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C233/65 , C07C235/64
Abstract: Provided is a 3,5-dihydroxybenzoic acid derivative, which shows an elastase inhibitory effect and an excellent effect of scavenging free radicals generated by UV irradiation, has an excellent anti-aging effect, and is useful for an anti-aging cosmetic composition. The 3,5-dihydroxybenzoic acid derivative is a compound represented by a formula 1, substituted with hydroxyl groups at 3,5-position thereof and the amide group being substituted with a bulky substituent. The 3,5-dihydroxybenzoic acid derivative is obtained by the method comprising the steps of: (A) reacting 3,5-dihydroxybenzoic acid with acetic anhydride to form 3,5-diacetyloxybenzoic acid; (B) forming an amide compound from the 3,5-diacetyloxybenzoic acid by using ethyl chloroformate and an oleophilic group; and (C) hydrolyzing the acetyl group of the amide compound to provide a 3,5-dihydroxybenzoic acid derivative.
Abstract translation: 本发明提供一种3,5-二羟基苯甲酸衍生物，其显示出弹性蛋白酶抑制作用，并且通过UV照射产生的清除自由基的优异效果，具有优异的抗老化作用，并且可用于抗老化化妆品组合物。 3,5-二羟基苯甲酸衍生物是由式3表示的化合物，其3,5-位被羟基取代且酰胺基被大体积取代基取代。 3,5-二羟基苯甲酸衍生物通过包括以下步骤的方法获得：（A）使3,5-二羟基苯甲酸与乙酸酐反应形成3,5-二乙酰氧基苯甲酸; （B）通过使用氯甲酸乙酯和亲油基团由3,5-二乙酰氧基苯甲酸形成酰胺化合物; 和（C）水解酰胺化合物的乙酰基得到3,5-二羟基苯甲酸衍生物。
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104.发明公开
公开(公告)号：KR1020070042298A
公开(公告)日：2007-04-23
申请号：KR1020050098057
申请日：2005-10-18
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 유용성 활성물질을 안정화한 수분산 양이온성 고분자 나노캡슐 및 이의 제조방법, 및 상기 수분산 양이온성 고분자 나노캡슐을 함유하는 화장료 조성물에 관한 것이다. 보다 상세하게는, 본 발명의 수분산 양이온성 고분자 나노캡슐은 (1) 활성물질을 흡착할 수 있는 양이온성 관능기를 갖는 소수성 고분자를 중합하는 단계; 및 (2) 상기 (1)단계의 소수성 고분자 및 유용성 활성성분을 유기용매에 용해시킨 후 교반하면서 수상과 유기상을 혼합시켜 에멀젼을 제조하고, 유기상을 증발시켜 수상에 존재하는 유용성 활성성분을 포집한 나노캡슐을 제조하는 단계;로 유용성 활성성분을 담지한 수분산 양이온성 고분자 나노 캡슐을 제조하며, 상기의 단계로 제조된 양이온성 고분자 나노캡슐은 유용성 활성물질이 고분자입자 내 존재하는 양이온성 그룹에 흡착되어 있으며, 이로 인해 활성물질을 입자 내부의 양이온 그룹과 고분자벽제에 의해 외부자극으로부터 차단하는 이중 안정화시스템으로 우수한 안정화효과를 나타낸다.
수분산 * 나노 캡슐 * 활성물질 * 양이온성 * 모이어티Abstract translation: 本文公开了包封油溶性活性成分的阳离子聚合物纳米胶囊和含有它们的化妆品组合物。 阳离子聚合物纳米胶囊的分子量为5,000-100,000，表面电位为5-100mV，粒度为50-500nm。 此外，还公开了含有阳离子聚合物纳米胶囊的化妆品组合物。
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公开(公告)号：KR1020070032520A
公开(公告)日：2007-03-22
申请号：KR1020050086828
申请日：2005-09-16
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61Q19/007 , A61Q19/008
Abstract: A skin external composition containing the extracts of Korean medicinal flowers is provided to express bright skin by covering pigmentation on the skin, maintain moisturizing effects for a long period of time, and improve wrinkle and elasticity of the skin. The skin external composition contains the extracts of at least one Korean medicinal flower selected from Althea rosea, Chrysanthemum morifolium, Prunus persica, Rosa rugosa and Nelumbo nucifera, wherein the amount of Korean medicinal flower extracts is 0.0001-10 wt.% based on the total weight of the composition. The extracts of Korean medicinal flowers are prepared by independently extracting Korean medicinal flowers with 70% ethanol at room temperature for 48 hours, filtering the extract with filter paper, and concentrating the filtered solution at 50 deg.C under reduced pressure.
Abstract translation: 提供含有韩国药用植物提取物的皮肤外用组合物，通过覆盖皮肤上的色素沉着，长时间保持保湿效果，并改善皮肤的皱纹和弹性来表现明亮的皮肤。 皮肤外用组合物含有至少一种韩国药用植物提取物，其选自蔷薇，菊花，桃李，罗莎和Nelumbo nucifera，其中韩国药用花提取物的量为总重量的0.0001-10重量％ 组合物的重量。 韩国药用植物提取物通过在室温下独立地提取70％乙醇的韩国药用植物油48小时，用滤纸过滤提取物，并在50℃减压浓缩滤液。
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Patent Agency Ranking
公开(公告)号：KR1020070028902A
公开(公告)日：2007-03-13
申请号：KR1020050083666
申请日：2005-09-08
Applicant: (주)아모레퍼시픽
Abstract: A cosmetic composition for suppressing sebum comprising catechins and kaempferol is provided to reduce activity of PPAR-gamma(peroxisome proliferator-activated receptor gamma) and suppress production of sebum, so that acnes symptom is alleviated. The cosmetic composition for suppressing sebum comprises catechins and kaempferol derived from green tea leaf, wherein the catechin is selected from (-)EGCG(epigallocatechin gallate), (-)GCG(gallocatechin gallate), (-)ECG(epicatechin gallate), (-)CG(catechin gallate), (-)EGC(epigallocatechin), (-)GC(gallocatechin), (-)EC(epicatechin), (+)EC(epicatechin), (-)CA(catechin) and (+)CA(catechin). The mixing ratio of catechins and kaempferol is 1:0.1-10, and the amounts of catechins and kaempferol are 0.001-30 wt.% respectively based on the total weight of the composition.
Abstract translation: 提供了用于抑制含有儿茶素和山奈酚的皮脂的化妆品组合物，以降低PPAR-γ（过氧化物酶体增殖物激活受体γ）的活性并抑制皮脂的产生，从而减轻痤疮症状。 用于抑制皮脂的化妆品组合物包括来自绿茶叶的儿茶素和山奈酚，其中儿茶素选自（ - ）EGCG（表没食子儿茶素没食子酸酯），（ - ）GCG（没食子儿茶素没食子酸酯），（ - ）ECG（表儿茶素没食子酸酯），（ - ）CG（儿茶素没食子酸酯），（ - ）EGC（儿茶素没食子酸酯），（ - ）GC（gallocatechin），（ - ）EC（表儿茶素），（+）EC ）CA（儿茶素）。 儿茶素和山奈酚的混合比为1：0.1-10，儿茶素和山奈酚的含量分别为组合物总重量的0.001-30重量％。
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公开(公告)号：KR100692099B1
公开(公告)日：2007-03-12
申请号：KR1020060024862
申请日：2006-03-17
Applicant: (주)아모레퍼시픽
Abstract: A skin cosmetic composition is provided to inhibit activity of 3beta-hydroxysteroid dehydrogenase and metabolic pathway thereof, thereby decreasing dihydrotestosterone(DHT), which is a final metabolite and being effective for improving sebum metabolism or acne. The skin cosmetic composition for inhibiting activity of 3beta-hydroxysteroid dehydrogenase comprises 0.001-30 wt.% of at least one selected from the group consisting of epigallocatechingallate(EGCG), gallocatechingallate(GCG), quercetin, kaempferol and myricetin as an effective ingredient.
Abstract translation: 提供皮肤化妆品组合物以抑制3β-羟基类固醇脱氢酶及其代谢途径的活性，从而降低作为最终代谢物的二氢睾酮（DHT），并有效改善皮脂代谢或痤疮。 用于抑制3β-羟基类固醇脱氢酶活性的皮肤化妆品组合物包含0.001-30重量％的选自表没食子儿茶素没食子酸酯（EGCG），没食子儿茶素没食子酸酯（GCG），槲皮素，山奈酚和杨梅黄酮作为有效成分。
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公开(公告)号：KR1020070013482A
公开(公告)日：2007-01-31
申请号：KR1020050067815
申请日：2005-07-26
Applicant: (주)아모레퍼시픽
IPC: C07D317/64
Abstract: Sesamol derivatives and a process for preparing the same compounds are provided to improve anti-oxidizing activity and stability of sesamol, recover the skin damaged by reactive oxygen species, prevent aging of biological membranes, and inhibit production of peroxides of unsaturated fatty acid and its derivatives. The sesamol derivatives represented by the formula(1) are provided, wherein the sesamol derivatives are prepared by reacting sesamol with adamantanol in an equivalence ratio of 1:1.0~1.3 under acid condition, and recrystallizing the resulting product in polar solvent; the acid is hydrochloric acid, nitric acid, sulfuric acid, p-toluenesulfonic acid, benzene sulfonic acid, acetic acid, trichloroacetic acid or trifluoroacetic acid; the solvent used in the reaction is dichloromethane, tetrahydrofuran, ethyl acetate, acetonitrile, chloroform, ethyl ether, trichloro ethylene, benzene or toluene; and the polar solvent is methanol, ethanol, isopropanol, acetone, acetonitrile or water.
Abstract translation: 提供了芝麻酚衍生物和制备相同化合物的方法，以提高芝麻素的抗氧化活性和稳定性，回收活性氧损伤的皮肤，防止生物膜老化，抑制不饱和脂肪酸及其衍生物过氧化物的产生 。 提供由式（1）表示的芝麻酚衍生物，其中芝麻酚衍生物通过在酸性条件下使芝麻酚与当量比为1：1.0〜1.3的金刚烷醇反应制备，并将所得产物在极性溶剂中重结晶; 酸是盐酸，硝酸，硫酸，对甲苯磺酸，苯磺酸，乙酸，三氯乙酸或三氟乙酸; 反应中使用的溶剂是二氯甲烷，四氢呋喃，乙酸乙酯，乙腈，氯仿，乙醚，三氯乙烯，苯或甲苯; 极性溶剂为甲醇，乙醇，异丙醇，丙酮，乙腈或水。
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公开(公告)号：KR100643514B1
公开(公告)日：2006-11-23
申请号：KR1020050041060
申请日：2005-05-17
Applicant: (주)아모레퍼시픽
IPC: C07C233/64 , A61K8/368
Abstract: Provided are a hydroxybenzoic acid amide compound which suppresses the generation of melanin, its preparation method, and a whitening cosmetic composition containing the compound. The hydroxybenzoic acid amide compound is represented by the formula 1, wherein R1 and R2 are H or OH. The method comprises the steps of dissolving hydroxybenzoic acid in a solvent, adding a catalyst and a base drop by drop, and reacting it with acetic anhydride to prepare an acetylated compound represented by the formula II; dissolving the acetylated compound of the formula II in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare an amide compound represented by the formula III; and reacting the amine compound of the formula III with a base to hydrolyze it (See the reaction scheme 1), wherein R3 and R4 is H or an acetoxy group.
Abstract translation: 本发明提供抑制黑色素生成的羟基苯甲酸酰胺化合物及其制备方法和含有该化合物的美白化妆品组合物。 羟基苯甲酸酰胺化合物由式1表示，其中R 1和R 2是H或OH。 该方法包括以下步骤：将羟基苯甲酸溶解在溶剂中，逐滴加入催化剂和碱，并使其与乙酸酐反应以制备式II表示的乙酰化化合物; 将式II的乙酰化的化合物溶解在溶剂中并加入碱，氯甲酸乙酯和金刚烷胺以制备式III表示的酰胺化合物; 和使式III的胺化合物与碱反应以水解（参见反应方案1），其中R 3和R 4是H或乙酰氧基。
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公开(公告)号：KR100636737B1
公开(公告)日：2006-10-20
申请号：KR1020050032607
申请日：2005-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C225/20
Abstract: Provided are a gallic acid adamantamine amide compound which inhibits the generation of melanin, a method for preparing the compound, and a cosmetic composition containing the compound. The gallic acid adamantamine amide compound is represented by the formula 1. The method comprises the steps of dissolving gallic acid in a solvent, adding a catalyst and a base to the solution drop by drop, and reacting it with acetic anhydride to prepare the acetylated compound represented by the formula II (See the reaction scheme 1); dissolving the acetylated compound in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare the amide compound represented by the formula III; and reacting the obtained amide compound with a base to hydrolyze it, thereby preparing the gallic acid adamantamine amide compound represented by the formula 1. Preferably the catalyst is dimethyl aminopyridine; and the base is triethylamine.
Abstract translation: 本发明提供抑制黑色素生成的没食子酸金刚胺酰胺化合物，其制备方法以及含有该化合物的化妆品组合物。 没食子酸金刚烷胺酰胺化合物由式1表示。该方法包括以下步骤：将没食子酸溶解在溶剂中，逐滴向溶液中加入催化剂和碱，并使其与乙酸酐反应以制备乙酰化的化合物 由式II表示（参见反应方案1）; 将乙酰化的化合物溶解在溶剂中，加入碱，氯甲酸乙酯和金刚烷胺制备式III所示的酰胺化合物; 并使所得酰胺化合物与碱反应以将其水解，从而制备式1代表的没食子酸金刚烷胺酰胺化合物。优选该催化剂是二甲基氨基吡啶; 碱是三乙胺。
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