METHODS AND COMPOSITIONS OF GENETIC STRESS RESPONSE SYSTEMS
    103.
    发明申请
    METHODS AND COMPOSITIONS OF GENETIC STRESS RESPONSE SYSTEMS 审中-公开
    遗传应力响应系统的方法与组成

    公开(公告)号:WO1992021747A1

    公开(公告)日:1992-12-10

    申请号:PCT/US1992004719

    申请日:1992-06-03

    Abstract: This invention relates to the identification, isolation, purification and manipulation of genetic stress response systems, and more particularly, to genes and expression products of those genes that are components of those systems. These components may be used to protect against potentially toxic stress factors. Stress factors include heat, alcohol and heavy metal ions. A family of stress protector proteins with apparent molecular weights about 100 kd, the hsp100 proteins, are an aspect of this invention. Other stress protector proteins are also within the scope of this invention to enhance or inhibit biological stress response. Applications of this invention to recombinant DNA technology, to commercial methods of food preparation and processing, and to methods of enhancing the stress response of plants and animals, are presented.

    Abstract translation: 本发明涉及遗传胁迫应答系统的鉴定,分离,纯化和操作,更具体地涉及作为那些系统的组分的那些基因的基因和表达产物。 这些组分可用于防止潜在的毒性应激因素。 应激因素包括热,酒精和重金属离子。 具有约100kd(hsp100蛋白)的表观分子量的应激保护蛋白家族是本发明的一个方面。 其他应力保护蛋白也在本发明的范围内,以增强或抑制生物应激反应。 本发明应用于重组DNA技术,食品制备和加工的商业方法,以及增强植物和动物应激反应的方法。

    HIV-RELATED ANTIGENS AND ANTIBODIES
    104.
    发明申请
    HIV-RELATED ANTIGENS AND ANTIBODIES 审中-公开
    与HIV相关的抗生素和抗体

    公开(公告)号:WO1989005821A1

    公开(公告)日:1989-06-29

    申请号:PCT/US1988004553

    申请日:1988-12-20

    Abstract: Disclosed are novel immunochemical reagents including non-neurotoxic peptides having amino acid sequence homology to loop sequences within residues 230 to 300 of the gp 120 glycoprotein of HIV-IIIB and antibodies thereto that are capable of in vitro inhibition of HIV-1 infectivity. The peptides and antibodies are useful in diagnostic assays and as active components of vaccine compositions for active and passive vaccination procedures.

    Abstract translation: 公开了新的免疫化学试剂,其包括与能够体外抑制HIV-1感染性的HIV-IIIB的gp120糖蛋白及其抗体的残基230至300的残基230至300内具有氨基酸序列同源性的非神经毒性试剂。 肽和抗体可用于诊断测定和作为主动和被动接种程序的疫苗组合物的活性组分。

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