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    USE OF HERPES SIMPLEX VIRUS ORF P PROTEIN IN REPRESSION OF VIRAL PROTEIN SYNTHESIS AND RELATED METHODS
    2.
    发明申请
    USE OF HERPES SIMPLEX VIRUS ORF P PROTEIN IN REPRESSION OF VIRAL PROTEIN SYNTHESIS AND RELATED METHODS 审中-公开
    使用草药复制病毒ORF P蛋白代替病毒蛋白质合成及相关方法

    公开(公告)号：WO1998008953A1

    公开(公告)日：1998-03-05

    申请号：PCT/US1997015149

    申请日：1997-08-28

    Applicant: ARCH DEVELOPMENT CORPORATION ,  BRUNI, Renato ,  ROIZMAN, Bernard

    Inventor： ARCH DEVELOPMENT CORPORATION

    IPC: C12N15/38

    CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2710/16622 ,  C12N2710/16643

    Abstract: The present invention is directed to methods and compositions relating to the treatment of herpes simplex virus infections and the screening of compounds for activity that inhibit or promote viral latency. The previously identified ORF P gene product now has been shown to interact with certain eukaryotic splicing factors and, in a cell infected with a herpesvirus containing a derepressed ORF P gene, ORF P can limit the splicing of at least two viral products. Given this function, it now is possible to screen for inhibitors and inducers of ORF P and, further, provide methods for maintaining and preventing viral latency.

    Abstract translation: 本发明涉及涉及治疗单纯疱疹病毒感染和筛选化合物以抑制或促进病毒潜伏期的活性的方法和组合物。 现在已经显示先前鉴定的ORF P基因产物与某些真核剪接因子相互作用，并且在含有去甲基化ORF P基因的疱疹病毒感染的细胞中，ORF P可以限制至少两种病毒产物的剪接。 鉴于此功能，现在可以筛选ORF P的抑制剂和诱导剂，并进一步提供维持和预防病毒潜伏期的方法。

    ANTIMICROBIAL AGENTS, DIAGNOSTIC REAGENTS, AND VACCINES BASED ON UNIQUE APICOMPLEXAN PARASITE COMPONENTS
    3.
    发明申请
    ANTIMICROBIAL AGENTS, DIAGNOSTIC REAGENTS, AND VACCINES BASED ON UNIQUE APICOMPLEXAN PARASITE COMPONENTS 审中-公开
    基于独特的APICOMPLEXAN PARASITE组件的抗菌试剂，诊断试剂和疫苗

    公开(公告)号：WO1998003661A2

    公开(公告)日：1998-01-29

    申请号：PCT/US1997012497

    申请日：1997-07-18

    Applicant: ARCH DEVELOPMENT CORPORATION ,  McLEOD, Rima, L., W. ,  ROBERTS, Craig, W. ,  ROBERTS, Fiona ,  JOHNSON, Jennifer, J. ,  METS, Laurens

    Inventor： ARCH DEVELOPMENT CORPORATION

    IPC: C12N15/52

    CPC classification number: A61K39/002 ,  A61K38/00 ,  C12N9/88 ,  C12N9/90 ,  G01N33/56905 ,  Y02A50/412 ,  Y02A50/58

    Abstract: This invention relates to uses of components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors.

    Abstract translation: 本发明涉及不包括psbA或PPi磷酸果糖激酶的植物样代谢途径的组分的用途，并且通常不在动物中操作或由质体DNA编码，以开发干扰Apicomplexan生长和存活的组合物。 途径的组分包括酶，转运肽和编码酶和肽的核苷酸序列，或这些核苷酸序列的启动子，其中抗体，反义分子和其它抑制剂被引导。 基于组分及其抑制剂开发诊断和治疗试剂和疫苗。

    GENETICALLY ENGINEERED CELLS THAT PRODUCE DOPAMINE
    6.
    发明申请
    GENETICALLY ENGINEERED CELLS THAT PRODUCE DOPAMINE 审中-公开
    生产多巴胺的遗传工程细胞

    公开(公告)号：WO1996005319A1

    公开(公告)日：1996-02-22

    申请号：PCT/US1995010291

    申请日：1995-08-11

    Applicant: ARCH DEVELOPMENT CORPORATION ,  KANG, Un, Jung ,  GAGE, Fred, H.

    Inventor： ARCH DEVELOPMENT CORPORATION

    IPC: C12N15/57

    CPC classification number: C12N9/0071 ,  A61K38/00 ,  A61K48/00 ,  C12N9/78 ,  C12N9/88

    Abstract: The present invention provides a process of increasing dopamine production in a cell comprising co-transfecting the cell with one or more expression vectors containing polynucleotides that encode tyrosine hydroxylase, aromatic L-amino acid decarboxylase and GTP cyclohydrolase. Cells transfected with such vectors and the use of such transformed cells to increase dopamine production in the central nervous system of animals are also provided.

    Abstract translation: 本发明提供了增加细胞中多巴胺产生的方法，包括用含有编码酪氨酸羟化酶，芳香族L-氨基酸脱羧酶和GTP环化水解酶的多核苷酸的一种或多种表达载体共转染细胞。 还提供了用这些载体转染的细胞和使用这样的转化细胞来增加动物中枢神经系统中的多巴胺产生。

    AUTOMATED METHOD AND SYSTEM FOR IMPROVED COMPUTERIZED DETECTION AND CLASSIFICATION OF MASSES IN MAMMOGRAMS
    9.
    发明申请
    AUTOMATED METHOD AND SYSTEM FOR IMPROVED COMPUTERIZED DETECTION AND CLASSIFICATION OF MASSES IN MAMMOGRAMS 审中-公开
    自动化方法和系统，用于改进计算机检测和分类在MAMMOGRAMS中的质量

    公开(公告)号：WO1995014979A1

    公开(公告)日：1995-06-01

    申请号：PCT/US1994013282

    申请日：1994-11-29

    Applicant: ARCH DEVELOPMENT CORPORATION

    Inventor： ARCH DEVELOPMENT CORPORATION ,  GIGER, Maryellen, L. ,  DOI, Kunio ,  LU, Ping ,  HUO, Zhimin

    IPC: G06K09/00

    CPC classification number: G06K9/00127 ,  G06T7/0012

    Abstract: A method and system for automated detection and classification of masses in mammograms. This method and system include the performance of iterative, multi-level gray level thresholding (202), followed by lesion extraction (203) and feature extraction techniques (205) for classifying true masses from false-postive masses and malignant masses from benign masses. The method and system provide improvements in the detection of masses including multi-gray-level thresholding (202) of the processed images to increase sensitivity and accurate region growing and feature analysis to increase specificity. Novel improvements in the classification of masses include a cumulative edge gradient orientation histogram analysis relative to the radial angle of the pixels in question; i.e. either around the margin of the mass or within or around the mass in question. The classification of the mass leads to a likelihood malignancy.

    Abstract translation: 乳房X线照片中质量自动检测和分类的方法和系统。 该方法和系统包括迭代，多级灰度阈值（202），随后的病变提取（203）和特征提取技术（205）的性能，用于从假性质量和良性肿块的恶性质量分类真实质量。 该方法和系统提供了质量检测的改进，包括处理图像的多灰度阈值（202），以增加灵敏度和准确的区域生长和特征分析以增加特异性。 质量分类的新改进包括相对于所讨论的像素的径向角的累积边缘梯度取向直方图分析; 即在质量的边缘周围或在所讨论的质量块内或周围。 质量的分类导致恶性肿瘤的可能性。

    VERTEBRATE APOPTOSIS GENE: COMPOSITIONS AND METHODS
    10.
    发明申请
    VERTEBRATE APOPTOSIS GENE: COMPOSITIONS AND METHODS 审中-公开
    VERTEBRATE APOPTOSIS GENE：组合物和方法

    公开(公告)号：WO1995000642A1

    公开(公告)日：1995-01-05

    申请号：PCT/US1994007089

    申请日：1994-06-22

    Applicant: ARCH DEVELOPMENT CORPORATION ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THOMPSON, Craig, B. ,  BOISE, Lawrence, H. ,  NUNEZ, Gabriel

    Inventor： ARCH DEVELOPMENT CORPORATION ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    IPC: C12N15/12

    CPC classification number: C07K14/4747 ,  C07K14/465

    Abstract: The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 (SEQ ID NO.5) that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

    Abstract translation: 本发明一般涉及获得和使用影响程序性脊椎动物细胞死亡的BCL-2（SEQ ID NO.5）以外的多肽的组合物和方法。 本发明还涉及编码那些多肽的多核苷酸，携带那些序列的重组载体，包含序列或载体的重组宿主细胞和重组多肽。 本发明还提供了在分析设计用于选择和改善能够改变程序性细胞死亡的物质用于诊断，药物设计和治疗应用的测定中使用分离的重组多肽的方法。

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