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    ELONGATED BIODEGRADABLE DEPOT FOR SUSTAINED DRUG RELEASE TO TREAT CHRONIC PELVIC PAIN
    101.
    发明申请
    ELONGATED BIODEGRADABLE DEPOT FOR SUSTAINED DRUG RELEASE TO TREAT CHRONIC PELVIC PAIN 审中-公开
    用于持续的药物释放以治疗慢性疼痛疼痛的延长生物降解剂

    公开(公告)号：WO2011139595A4

    公开(公告)日：2012-08-16

    申请号：PCT/US2011033545

    申请日：2011-04-22

    Applicant: MEDTRONIC INC ,  BISCHOFF THOMAS C ,  HILDEBRAND KEITH R ,  HOBOT CHRISTOPHER M

    Inventor： BISCHOFF THOMAS C ,  HILDEBRAND KEITH R ,  HOBOT CHRISTOPHER M

    IPC: A61K9/70 ,  A61K9/00

    CPC classification number: A61K9/0085 ,  A61B17/3401 ,  A61K9/0024

    Abstract: The invention describes a device for administering a therapeutic agent to a subject at a sustained rate over a period of time, the device being shaped, sized and adapted for administering the therapeutic agent into the region of the spinal column of the subject, the device comprising: an elongated first polymeric substrate having a proximal end, a distal end and diameter or width of about 1 mm to about 10 mm and a length of about 4 cm to about 35 cm; optionally, an elongated second polymeric substrate positioned within the first polymeric substrate; and at least one therapeutic agent, loaded into or onto the first polymeric substrate or second polymeric substrate or both, wherein the therapeutic agent is available for diffusion into the region of the spinal column of the subject.

    Abstract translation: 本发明描述了一种用于在一段时间内以持续速率向受试者施用治疗剂的装置，所述装置被成形，尺寸和适于将治疗剂施用到受试者的脊柱的区域中，所述装置包括 ：细长的第一聚合物基材，其具有近端，远端和约1mm至约10mm的直径或宽度，以及约4cm至约35cm的长度; 可选地，位于第一聚合物基材内的细长的第二聚合物基材; 和至少一种治疗剂，其加载到第一聚合物基质或第二聚合物基质或二者之中或之上，其中治疗剂可用于扩散到受试者的脊柱的区域中。

    AN IMPLANTABLE DRUG DEPOT HAVING A REVERSIBLE PHASE TRANSITION MATERIAL FOR TREATMENT OF PAIN AND/OR INFLAMMATION
    102.
    发明申请
    AN IMPLANTABLE DRUG DEPOT HAVING A REVERSIBLE PHASE TRANSITION MATERIAL FOR TREATMENT OF PAIN AND/OR INFLAMMATION 审中-公开
    具有用于治疗疼痛和/或炎症的可逆相转移材料的可植入药物剂

    公开(公告)号：WO2011016881A4

    公开(公告)日：2012-01-19

    申请号：PCT/US2010030689

    申请日：2010-04-12

    Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M

    Inventor： HOBOT CHRISTOPHER M

    IPC: A61K9/50 ,  A61K9/00

    CPC classification number: A61K9/0024 ,  A61K9/0004 ,  A61K9/5031

    Abstract: Effective treatments of pain and/or inflammation are provided that utilize a reversible phase transition material of a drug depot. When heat, cold or another suitable form of energy, e.g., ultrasound energy is applied to the reversible phase transition material, the release of an analgesic and/or anti-inflammatory agent from a drug depot is increased.

    Abstract translation: 提供利用药物贮库的可逆相变材料的疼痛和/或炎症的有效治疗。 当将热，冷或其它适当形式的能量（例如超声能量）施加到可逆相变材料时，药物剂库中的止痛剂和/或抗炎剂的释放增加。

    SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL
    104.
    发明申请
    SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL 审中-公开
    可生物降解材料中的SULINDAC配方

    公开(公告)号：WO2009129510A3

    公开(公告)日：2010-01-21

    申请号：PCT/US2009041042

    申请日：2009-04-17

    Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  COX S MARK ,  SHAW KATARA

    Inventor： ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  COX S MARK ,  SHAW KATARA

    IPC: A61K9/00 ,  A61K31/255 ,  A61P29/00

    CPC classification number: A61K31/255 ,  A61K9/0024 ,  A61K9/204

    Abstract: Effective treatments of pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulindac or a pharmaceutically acceptable salt thereof at or near a target site, one can relieve pain and/or inflammation caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days, at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    Abstract translation: 提供长时间的疼痛和/或炎症的有效治疗。 通过施用有效量的舒林酸或其药学上可接受的盐在目标部位或其附近，可以缓解由不同来源引起的疼痛和/或炎症，包括但不限于脊椎间盘突出症（即坐骨神经痛），脊柱松解症， 狭窄，背痛和关节疼痛，以及伴随手术的疼痛。 当在生物可降解聚合物内提供适当的制剂时，这种缓解可以持续至少三天，至少二十五天。 在一些实施方案中，缓解剂可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE
    105.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE 审中-公开
    用于治疗术后疼痛的方法和组合

    公开(公告)号：WO2009129437A2

    公开(公告)日：2009-10-22

    申请号：PCT/US2009040910

    申请日：2009-04-17

    Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

    Inventor： KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

    IPC: A61K9/00 ,  A61K31/4162

    CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K31/4168 ,  A61K47/34 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/604

    Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

    Abstract translation: 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物贮存库，所述可植入药物储库包含治疗有效量的可乐定或其药学上可接受的盐和聚合物; 其中所述贮存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述贮库能够释放（i）约5％至约45％的可乐定或其药学上可接受的盐相对于 在最多48小时的第一时间内装载在药物贮库中的可乐定或其药学上可接受的盐的总量和（ii）可乐定或其药学上可接受的盐的约55％至约95％相对于 至少3天的随后期间，将可乐定或其药学上可接受的盐装载在药物贮库中。

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