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    Medical device and method including polymer having biologically active agent therein
    1.
    发明专利
    Medical device and method including polymer having biologically active agent therein 有权
    包括具有生物活性剂的聚合物的医疗装置和方法

    公开(公告)号：JP2013090952A

    公开(公告)日：2013-05-16

    申请号：JP2013011995

    申请日：2013-01-25

    Applicant: Medtronic Inc ,  メドトロニック,インコーポレイテッド

    Inventor： MCDONALD PHILLIP EDWARD

    IPC: A61L31/00 ,  A61K31/192 ,  A61K31/4168 ,  A61K31/57 ,  A61K31/573 ,  A61P25/04

    CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61K9/1688 ,  A61K31/4162 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/622 ,  A61L2300/63 ,  C08L67/04

    Abstract: PROBLEM TO BE SOLVED: To provide a novel medical device that can release a biologically active agent.SOLUTION: The implant is a drug loaded polymer device 100, such as a rod, designed to control the release of the biologically active agent 20, such as clonidine or its derivatives, such as clonidine HCl for a prolonged period of time, such as 2 months, 3 months, 4 months, and even 4.5 months. The polymer 10 is preferably a biodegradable polymer, such as poly(lactide-co-glycolide) or polylactic acid/polylactide. The challenge in using the HCl salt forms of drugs such as clonidine, is controlling the release of the highly water soluble drug for up to 4.5 months. It has been found that by controlling the particle size distribution of the drug powder, the drug distribution within the polymer matrix is more uniform and can be controlled. Therefore, the large aggregates, which cause rapid drug release can be eliminated.

    Abstract translation: 要解决的问题：提供可释放生物活性剂的新型医疗装置。 解决方案：植入物是负载药物的聚合物装置100，例如棒，设计用于长时间控制生物活性剂20如可乐定或其衍生物如可乐定HCl的释放， 如2个月，3个月，4个月甚至4.5个月。 聚合物10优选是可生物降解的聚合物，例如聚（丙交酯 - 共 - 乙交酯）或聚乳酸/聚丙交酯。 使用盐酸盐形式的药物如可乐定的挑战是控制高水溶性药物释放长达4.5个月。 已经发现，通过控制药物粉末的粒度分布，聚合物基质内的药物分布更均匀并且可以被控制。 因此，可以消除导致快速释药的大骨料。 版权所有（C）2013，JPO＆INPIT

    Methods and compositions for treating post-operative pain comprising clonidine
    5.
    发明专利
    Methods and compositions for treating post-operative pain comprising clonidine 未知

    公开(公告)号：AU2009236157B2

    公开(公告)日：2015-05-21

    申请号：AU2009236157

    申请日：2009-04-17

    Applicant: MEDTRONIC INC ,  WARSAW ORTHOPEDIC INC

    Inventor： WOHABREBBI AMIRA ,  HOBOT CHRISTOPHER M ,  KING VANJA MARGARETA ,  CARTER TROY ,  MCKAY WILLIAM F ,  MCDONALD PHILLIP EDWARD

    IPC: A61K9/00 ,  A61K9/20 ,  A61K31/4162 ,  A61K47/34

    Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

    METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE
    9.
    发明专利
    METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE 未知

    公开(公告)号：CA2700389A1

    公开(公告)日：2009-10-22

    申请号：CA2700389

    申请日：2009-04-17

    Applicant: MEDTRONIC INC ,  WARSAW ORTHOPEDIC INC

    Inventor： KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

    IPC: A61K9/00 ,  A61K9/20 ,  A61K31/4162 ,  A61K47/34

    Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

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