公开(公告)号：EP2929019A1

公开(公告)日：2015-10-14

申请号：EP13826999.8

申请日：2013-12-06

Applicant: Universität Hamburg

Inventor： RENTMEISTER, Andrea ,  STUMMER, Daniela

IPC: C12N9/10 ,  C07H19/00 ,  C07H21/02

CPC classification number: C12N9/1007 ,  C12P19/32 ,  C12P19/34 ,  C12Y201/01

Abstract: The invention provides an agent and method for modifying the 5' cap of RNA, for example for the purposes of isolation and analysis. According to one aspect the invention provides modified enzymes, namely modified trimethylguanosine synthases 2 from
Giardia lamblia (GlaTGS2), the enzymatic activity of which is changed such that as compared to wild type enzymes the former can use AdoMet analogues better as cofactors.

Abstract translation: 用于修饰RNA的5'帽的试剂和方法，例如用于分离和分析的目的。 根据一个方面，本发明提供了修饰的酶，即来自贾第鞭毛虫（GlaTGS2）的改性的三甲基鸟苷合酶2，其酶活性改变，使得与野生型酶相比，前者可以更好地使用AdoMet类似物作为辅因子。

公开(公告)号：NL2013042C

公开(公告)日：2015-07-09

申请号：NL2013042

申请日：2014-06-20

Applicant: DNA GREEN GROUP B V

Inventor： VLIELANDER IZAAK JOHANNES ,  LANG CHUNTING ,  MARIS PAULUS CORNELIS ,  PEETERS ROGER ADRIANUS

IPC: C07K14/415 ,  C12N9/10 ,  C12N15/82

CPC classification number: C12N9/1007 ,  A01H5/02 ,  A01H6/32 ,  C07K14/415 ,  C12N15/827 ,  C12Y201/01

Abstract: The present invention relates to proteins capable of providing a decorative flowering phenotype in plants and especially in plants belonging to the Kalanchoe genus. The present invention also relates to nucleic acid sequences, or cDNA sequences, and genes encoding the present proteins. The present invention further relates to use of the present proteins, nucleic acid sequences and genes for selecting decorative flowering Kalanchoe plants and decorative flowering Kalanchoe plants comprising the present proteins, mRNA forms of the present cDNAs or the present genes. Specifically, the present invention relates to proteins comprising an amino acid substitution of the amino acid histidine at position 136 and/or the amino acid alanine at position 338 of the methyl transferase protein of a Kalanchoe plant, wherein the amino acid substitution provides a decorative flowering phenotype in the present Kalanchoe plants.

公开(公告)号：US12065668B2

公开(公告)日：2024-08-20

申请号：US17450135

申请日：2021-10-06

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung ,  Morgan Maeder

IPC: C12N15/90 ,  C07K14/005 ,  C07K14/195 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/10 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85

CPC classification number: C12N15/907 ,  C07K14/005 ,  C07K14/195 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12Y301/21004 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00

Abstract: Methods and constructs for RNA-guided targeting of heterologous functional domains such as transcriptional activators to specific genomic loci.

公开(公告)号：US20240117394A1

公开(公告)日：2024-04-11

申请号：US17876134

申请日：2022-07-28

Applicant: ATX PHARMERS LLC

Inventor： Vivek PANDYA ,  Tamsen VALOIR

IPC: C12P17/10 ,  C12N1/16 ,  C12N1/20 ,  C12N9/02 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12N15/74 ,  C12N15/81

CPC classification number: C12P17/10 ,  C12N1/16 ,  C12N1/20 ,  C12N9/0083 ,  C12N9/1007 ,  C12N9/1205 ,  C12N9/88 ,  C12N15/52 ,  C12N15/74 ,  C12N15/81 ,  C12N2830/002 ,  C12Y114/99 ,  C12Y201/01 ,  C12Y207/01 ,  C12Y401/01

Abstract: Microbes are transformed with psilocybin genes under the control of weak or medium level promoter to make low levels of psilocybin therein. Low dose, microdose and sub-microdose foodstuff are then made with such microbes.

公开(公告)号：US11920152B2

公开(公告)日：2024-03-05

申请号：US17099503

申请日：2020-11-16

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung ,  James Angstman ,  Shengdar Tsai

IPC: C07H21/02 ,  C07K14/005 ,  C07K14/195 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/10 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N15/90

CPC classification number: C12N15/907 ,  C07K14/005 ,  C07K14/195 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12Y301/21004 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

公开(公告)号：US11905535B2

公开(公告)日：2024-02-20

申请号：US17812826

申请日：2022-07-15

Applicant: EMPYREAN NEUROSCIENCE, INC.

Inventor： Thomas Henley ,  Modassir Choudhry ,  Jose Fernandez-Gomez

IPC: C12N9/02 ,  A61K36/07 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88

CPC classification number: C12N9/0083 ,  A61K36/07 ,  C12N9/1007 ,  C12N9/1205 ,  C12N9/88 ,  C12Y114/99 ,  C12Y201/01 ,  C12Y207/01 ,  C12Y401/01

Abstract: Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psilocin compositions generated by the provided methods.

公开(公告)号：US20230372454A1

公开(公告)日：2023-11-23

申请号：US18248648

申请日：2021-10-12

Applicant: ANIMUSCURE INC.

Inventor： Jong Sun KANG ,  Hye Been KIM ,  Su Bin AN

IPC: A61K38/45 ,  A61P21/00 ,  G01N33/50

CPC classification number: A61K38/45 ,  C12Y201/01 ,  A61P21/00 ,  G01N33/5058 ,  G01N2333/91011

Abstract: The present invention relates to a use for, by using the protein arginine methyltransferase 1 (PRMT1) protein or a gene encoding the same, preventing or treating a neuromuscular disease induced by motor neurons, particularly, damage to motor neurons caused by oxidative stress in the neuromuscular junction; and a method for screening a candidate material for activating the expression of PRMT1. PRMT1 deficiency in the motor nerve or neuromuscular junction induces aggravated degenerative motor nerve damage caused by aging, and DNA damage caused by oxidative stress and inflammation, thereby enabling the induction of neuromuscular disease, and thus the disease may be treated through the overexpression and activity of the PRMT1 protein and a gene encoding the same.

公开(公告)号：US20230220357A1

公开(公告)日：2023-07-13

申请号：US17765692

申请日：2020-09-25

Applicant: Suntory Holdings Limited

Inventor： Noriko Nakamura ,  Naoko Okitsu ,  Yukihisa Katsumoto

IPC: C12N9/10 ,  C12N9/02 ,  C12N9/88 ,  C12N15/82 ,  A01H6/74 ,  A01H5/02

CPC classification number: C12N9/1051 ,  C12N9/0071 ,  C12N9/88 ,  C12N9/1007 ,  C12Y204/01 ,  C12Y114/14 ,  C12Y402/01105 ,  C12Y201/01 ,  C12N15/825 ,  A01H6/749 ,  A01H5/02

Abstract: Transgenic plants with blue flower color, or their inbred or outbred progeny, or their propagules, partial plant bodies, tissues or cells, are provided. A buckwheat-derived C-glucosyltransferase (CGT) gene or its homolog is transferred into a host plant to cause delphinidin-type anthocyanins and flavone mono-C-glycosides to be copresent in the plant cells.

公开(公告)号：US20190194707A1

公开(公告)日：2019-06-27

申请号：US15764644

申请日：2016-09-30

Applicant: SYMRISE AG ,  LEIBNITZ-INSTITUT FUER PFLANZENBIOCHEMIE

Inventor： Ludger A. WESSJOHANN ,  Susann HERRMANN ,  Martin DIPPE ,  Torsten GEISSLER ,  Katrin GEISSLER ,  Jakob Peter LEY

IPC: C12P17/06 ,  C12P7/42 ,  C12P7/22 ,  C12P17/10 ,  C12P7/26 ,  C12N9/10 ,  C12N9/02

CPC classification number: C12P17/06 ,  C12N9/0071 ,  C12N9/1007 ,  C12P7/22 ,  C12P7/26 ,  C12P7/42 ,  C12P17/10 ,  C12Y114/14001 ,  C12Y201/01

Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.

公开(公告)号：US20180208921A1

公开(公告)日：2018-07-26

申请号：US15870659

申请日：2018-01-12

Applicant: The General Hospital Corporation

Inventor： J. Keith Joung ,  James Angstman ,  Jeffry D. Sander ,  Morgan Maeder ,  Shengdar Tsai

IPC: C12N15/10 ,  C07K14/005 ,  C12N9/22 ,  C12N9/96 ,  C12N15/85 ,  C12N9/02 ,  C12N15/63 ,  C12N9/16 ,  C07K14/195 ,  C12N9/10 ,  C12N15/01

CPC classification number: C12N15/907 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/22 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.