公开(公告)号：US20230168199A1

公开(公告)日：2023-06-01

申请号：US18102333

申请日：2023-01-27

Applicant: Bioaxial SAS

Inventor： Gabriel Y. Sirat

IPC: G01N21/64 ,  G02B21/36

CPC classification number: G01N21/6458 ,  G02B21/365 ,  G01N2201/066

Abstract: A super resolution technique, intended mainly for fluorescence microscopy, acquires the three-dimensional position of an emitter, through a hybrid method, including a number of steps.
In a first step the two-dimensional position of an emitter is acquired, using a technique, named in this application as an Abbe’s loophole technique., In this technique a doughnut, or a combination of distributions, having a zero intensity at the combined center of the distributions, is projected onto the sample containing the emitter, under conditions wherein the doughnut null is moved towards the emitter to reach a position in which the emitter does not emit light.
In a second step, an axial measurement is obtained using a 3D shaping method, characterized by the fact that the emitted light is shaped by an additional optical module creating a shape of the light emitted by the emitter, this shape being dependent of the axial position and means to retrieve the axial position from the shape.

公开(公告)号：US10001467B2

公开(公告)日：2018-06-19

申请号：US15170508

申请日：2016-06-01

Applicant: Korea Advanced Institute of Science and Technology

Inventor： YongKeun Park ,  Jonghee Yoon ,  KyeoReh Lee

IPC: G01N21/47 ,  G01N33/483 ,  G01N33/02 ,  G01N21/49

CPC classification number: G01N33/483 ,  G01N15/06 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/02 ,  G01N2015/0065 ,  G01N2015/0687 ,  G01N2015/0693 ,  G01N2021/479 ,  G01N2201/06113 ,  G01N2201/066

Abstract: An apparatus and method for detecting microbes use laser speckles. The apparatus includes a light source configured to irradiate light into a sample to detect microbes, and a measuring part configured to measure laser speckles, which are formed due to a multiple scattering of the light which is incident into the sample, every reference time and to measure concentration of the microbes contained in the sample based on temporal correlation of the measured laser speckles.

公开(公告)号：US20180100797A1

公开(公告)日：2018-04-12

申请号：US15725550

申请日：2017-10-05

Applicant: GasPorOx AB

Inventor： Märta Lewander Xu ,  Johannes Swartling ,  Daniel Karlsson ,  Patrik Lundin ,  Joan Sandberg

IPC: G01N21/39 ,  G01N21/03 ,  G01N21/61

CPC classification number: G01N21/39 ,  G01N21/0303 ,  G01N21/27 ,  G01N21/274 ,  G01N21/61 ,  G01N2021/0364 ,  G01N2201/06113 ,  G01N2201/066

Abstract: A system and method for measuring a concentration of a gas in a container having at least one flexible or variable side or wall. The system and method comprising creating a determinable optical path length through the container having a shape. Positioning a light source head and a detector head against at least one of the least one flexible or variable side or wall. Transmitting a light signal between the light source head and the detector head through the determinable optical path length. Determining the concentration of the gas in the container based on detected light and the determinable optical path length.

公开(公告)号：US20170059482A1

公开(公告)日：2017-03-02

申请号：US15078462

申请日：2016-03-23

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Sangkyu KIM ,  Kunsun EOM ,  Myounghoon JUNG

IPC: G01N21/55 ,  A61B5/00 ,  G01N33/483 ,  G01N21/59 ,  G01N21/64

CPC classification number: G01N21/55 ,  A61B5/0071 ,  A61B5/0075 ,  G01N21/255 ,  G01N21/31 ,  G01N21/359 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/483 ,  G01N2021/6471 ,  G01N2201/0221 ,  G01N2201/066 ,  G01N2201/067 ,  G01N2201/13 ,  G02B26/005 ,  G02B26/026 ,  G02B26/08

Abstract: An optical sensor and a method of operating the optical sensor are provided. The optical sensor includes a light source configured to emit a light, and a path adjuster configured to adjust a traveling path of the light to reflect the light at a first time, and allow the light to pass through the path adjuster at a second time. The optical sensor further includes a light receiver configured to receive a reference light among the reflected light, and receive, among the light passing through the path adjuster, a measurement light related to a target material.

Abstract translation: 提供光学传感器和操作光学传感器的方法。 光学传感器包括被配置为发光的光源，以及路径调整器，被配置为调整光的行进路径以在第一时间反射光，并允许光在第二时间通过路径调节器。 光学传感器还包括被配置为在反射光中接收参考光的光接收器，并且在穿过路径调节器的光中接收与目标材料相关的测量光。

公开(公告)号：US20170038296A1

公开(公告)日：2017-02-09

申请号：US15304359

申请日：2015-05-13

Applicant: Konica Minolta, Inc.

Inventor： Akihiro FUJIMOTO

IPC: G01N21/3581

CPC classification number: G01N21/3581 ,  G01N21/3586 ,  G01N2201/061 ,  G01N2201/066

Abstract: A detection device having: a terahertz wave generation element; a terahertz wave detection element; a first transmission path arranged upon the terahertz wave generation element; a second transmission path arranged upon the terahertz wave detection element; and a sealed section arranged between the terahertz wave generation element and the terahertz wave detection element and separated from the first transmission path and the second transmission path, so as to surround the first transmission path and the second transmission path. A space between an emission surface in the first transmission path and an incident surface in the second transmission path is connected to a space between the first transmission path and the sealed section and to a space between the second transmission path and the sealed section.

Abstract translation: 一种具有：太赫兹波发生元件的检测装置; 太赫兹波检测元件; 布置在太赫兹波发生元件上的第一传输路径; 布置在太赫兹波检测元件上的第二传输路径; 以及设置在太赫兹波发生元件和太赫兹波检测元件之间并与第一传输路径和第二传输路径分离的密封部分，以便围绕第一传输路径和第二传输路径。 第一传输路径中的发射表面与第二传输路径中的入射表面之间的空间连接到第一传输路径和密封部分之间的空间以及第二传输路径和密封部分之间的空间。

公开(公告)号：US20160363531A1

公开(公告)日：2016-12-15

申请号：US15174434

申请日：2016-06-06

Applicant: CANON KABUSHIKI KAISHA

Inventor： Tomohiro Sugimoto

IPC: G01N21/45 ,  G01B11/06 ,  G01B9/02

CPC classification number: G01N21/45 ,  G01B9/02024 ,  G01B11/06 ,  G01M11/0271 ,  G01N2201/066 ,  G01N2201/068 ,  G01N2201/12

Abstract: A phase refractive index of a test object is measured with high accuracy. A phase difference between a reference light beam and a test light beam is measured by dividing light from a light source into the reference light beam and the test light beam, and causing interference between the test light beam transmitted through the test object and the reference light beam. A phase refractive index of the test object is calculated by calculating a value corresponding to an integral multiple of 2π included in the phase difference, based on a slope of a phase refractive index of a reference object with respect to wavelength.

Abstract translation: 以高精度测量被测物体的相位折射率。 通过将来自光源的光分成参考光束和测试光束来测量参考光束和测试光束之间的相位差，并且使透过测试对象的测试光束与参考光之间的干涉 光束。 基于相对于波长的参考对象的相位折射率的斜率，通过计算对应于包括在相位差中的2π的整数倍的值来计算被测物体的相位折射率。

公开(公告)号：US20140008539A1

公开(公告)日：2014-01-09

申请号：US13931348

申请日：2013-06-28

Applicant: John Magie COFFIN ,  Damian W. ASHMEAD ,  Todd C. STROTHER

Inventor： John Magie COFFIN ,  Damian W. ASHMEAD ,  Todd C. STROTHER

IPC: G01N21/25

CPC classification number: G01N21/0303 ,  G01J3/0202 ,  G01N21/255 ,  G01N21/35 ,  G01N2021/3595 ,  G01N2201/066

Abstract: The present invention is thus directed to an automated system and method of varying the optical path length in a sample that a light from a spectrophotometer must travel through. Such arrangements allow a user to easily vary the optical path length while also providing the user with an easy way to clean and prepare a transmission cell for optical interrogation. Such path length control can be automatically controlled by a programmable control system to quickly collect and stores data from different path lengths as needed for different spectrographic analysis. Such a methodology and system, as presented herein, is able to return best-match spectra with far fewer computational steps and greater speed than if all possible combinations of reference spectra are considered.

Abstract translation: 因此，本发明涉及一种自动化系统和方法，其改变来自分光光度计的光必须穿过的样品中的光程长度。 这样的布置允许用户容易地改变光路长度，同时还为用户提供了清洁和准备用于光询问的传输单元的简单方法。 这种路径长度控制可以由可编程控制系统自动控制，以便根据不同光谱分析的需要快速收集和存储来自不同路径长度的数据。 如本文所述，这种方法和系统能够以比考虑参考光谱的所有可能组合的方式更少的计算步骤和更大的速度返回最佳匹配光谱。

公开(公告)号：US20120301872A1

公开(公告)日：2012-11-29

申请号：US13510975

申请日：2010-11-17

Applicant: Stig Tormod

Inventor： Stig Tormod

IPC: G01N21/62 ,  B01L9/00 ,  G01N21/64 ,  G01N21/76 ,  B82Y15/00

CPC classification number: G01N21/6456 ,  G01N21/255 ,  G01N21/6454 ,  G01N21/6458 ,  G01N2021/6469 ,  G01N2201/066 ,  G02B21/16

Abstract: The invention relates to systems and methods for improving optical detection and sensitivity in situations in which emission of luminescent light is monitored. It is provided a sample carrier which achieves increased sensitivity of luminescent light detection. The sample carrier comprises a sample carrying part and a light reflecting part; wherein the light reflecting part is positioned to allow an optical collection and detection system to collect not only luminescent light emitted from the sample positioned on the sample carrying part in a direction of the optical collection and detection system, but also luminescent light emitted from the sample in a direction away from the optical collection and detection system and reflected in the direction of the optical collection and detection system via the light reflecting part. When an excitation light source is needed, the light reflecting part also allows the excitation light rays passing through the sample to hit the light reflecting part, and reflect back in the opposite direction thus the reflected excitation light also passes through the sample. Also provided are methods of using such a sample carrier.

Abstract translation: 本发明涉及用于在监测发光的发光的情况下改善光学检测和灵敏度的系统和方法。 提供了一种能够提高发光光检测灵敏度的样品载体。 样品载体包括样品携带部分和光反射部分; 其特征在于，所述光反射部被配置为允许光学收集和检测系统不仅从位于所述光学收集和检测系统的方向上的样品承载部分上的样品发射的发光，而且从所述样品发射的发光 在远离光学收集和检测系统的方向上，并经由光反射部分在光学收集和检测系统的方向上反射。 当需要激发光源时，光反射部分还允许通过样品的激发光线撞击光反射部分，并且反向反向，因此反射的激发光也通过样品。 还提供了使用这种样品载体的方法。

公开(公告)号：US20080123094A1

公开(公告)日：2008-05-29

申请号：US11792097

申请日：2005-12-01

Applicant: Henrik Vilstrup Juhl

Inventor： Henrik Vilstrup Juhl

IPC: G01J3/427

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01N2021/036 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/1293

Abstract: A spectrophotometer (2) comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest withiA spectrophotometer (2) comprise a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest within the retained sample can be obtained.

Abstract translation: 一种分光光度计（2），包括辐射源（6），优选光辐射，被设置成朝向样品保持器（4）中的样品发射多个波长的辐射;以及检测装置8，用于在与 例子。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的强度相关输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 多个不同的路径长度并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，用分光光度计（2）存在感兴趣的物质的指示包括辐射源（6） 优选地，光辐射被设置为发射多个波长的辐射朝向样本保持器（4）中的样本;以及检测装置8，用于在与样本相互作用之后检测辐射。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的强度相关输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 多个不同的路径长度，并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，由此可以获得在保留的样本内存在感兴趣的物质的指示。

公开(公告)号：US20060044560A1

公开(公告)日：2006-03-02

申请号：US11200086

申请日：2005-08-10

Applicant: Hiromi Takahashi

Inventor： Hiromi Takahashi

IPC: G01N21/00

CPC classification number: G01N21/552 ,  G01N2201/066 ,  G01N2201/08

Abstract: The device for measuring an optical absorption characteristic of a sample according to the present invention comprising a light source, a optical wave-guide having light input surface(s) and light output surface(s) that are opposite to each other, and a light reflecting surface on which a sample to be measured is disposed, through which the light passes and is reflected by a total reflection on the sample, one or more light transmitting means arranged between the light output surface of the optical wave-guide and the light input surface of the optical wave-guide so that the light is again entered into the optical wave-guide, and a processing device which receives the light re-exited from the optical wave-guide through the output surface and detects the optical absorption characteristics of the sample on the basis of the light received, whereby the light which passes through the optical wave-guide is conducted to the optical wave-guide again, the light is again entered the optical wave-guide, and the light is again reflected on the sample (FIG. 1).

Abstract translation: 根据本发明的用于测量样品的光吸收特性的装置，包括光源，具有彼此相对的光输入表面和光输出表面的光波导，以及光 配置有被测定样品的反射面，光通过该反射面，被样品的全反射反射，配置在光波导的光输出面和光输入面之间的一个或多个光传输单元 表面，使得光再次进入光波导，以及处理装置，其接收从光波导通过输出表面重新退出的光，并检测光波导的光吸收特性 基于受光的样品，通过光波导的光再次传导到光波导，光再次进入光波导， 引导，并且光再次反映在样品上（图1）。 1）。