公开(公告)号：EP0355738A3

公开(公告)日：1991-02-27

申请号：EP89115264.7

申请日：1989-08-18

Applicant: HITACHI, LTD.

Inventor： Hashimoto, Hiroshi ,  Umetsu, Hiroshi ,  Imai, Kyoko ,  Kawase, Masumi (née Suzuki)

IPC: G01N21/64 ,  G01N35/00

CPC classification number: G01N21/64 ,  G01N21/6428 ,  G01N2201/0648 ,  G01N2201/124

Abstract: A fluorophotometer for use in automatic equip­ment of chemical analysis is disclosed which includes a shutter (45) provided in an optical system (17 to 22, 25) on the exciting light side for blocking the optical path of exciting light, a shutter driving device (44) for driving the shutter so that the shutter is kept at a state that the optical path of exciting light is blocked and then kept a state that the optical path of exciting light is made open, each time a train of reaction vessels is intermittently moved, and a processor (43) for storing a first output signal which is delivered from a photodetector (30) for the detection of fluorescence in a period when the optical path of exciting light is blocked, and for correcting a second output signal which is delivered from the photodetector in a period when the optical path of exciting light is made open, by the first output signal. Further, a method of measuring the intensity of fluorescence in the automatic equipment of chemical analysis is disclosed.

公开(公告)号：EP0355738A2

公开(公告)日：1990-02-28

申请号：EP89115264.7

申请日：1989-08-18

Applicant: HITACHI, LTD.

Inventor： Hashimoto, Hiroshi ,  Umetsu, Hiroshi ,  Imai, Kyoko ,  Kawase, Masumi (née Suzuki)

IPC: G01N21/64 ,  G01N35/00

CPC classification number: G01N21/64 ,  G01N21/6428 ,  G01N2201/0648 ,  G01N2201/124

Abstract: A fluorophotometer for use in automatic equip­ment of chemical analysis is disclosed which includes a shutter (45) provided in an optical system (17 to 22, 25) on the exciting light side for blocking the optical path of exciting light, a shutter driving device (44) for driving the shutter so that the shutter is kept at a state that the optical path of exciting light is blocked and then kept a state that the optical path of exciting light is made open, each time a train of reaction vessels is intermittently moved, and a processor (43) for storing a first output signal which is delivered from a photodetector (30) for the detection of fluorescence in a period when the optical path of exciting light is blocked, and for correcting a second output signal which is delivered from the photodetector in a period when the optical path of exciting light is made open, by the first output signal. Further, a method of measuring the intensity of fluorescence in the automatic equipment of chemical analysis is disclosed.

Abstract translation: 一种用于在化学分析的自动设备使用荧光光度计是圆盘游离缺失，其包括快门（45），用于阻挡激发光的光路设置在光学系统（17〜22，25）上的激发光侧，快门驱动装置（ 44）用于驱动快门所以做了快门保持在状态没有激发光的光路被阻断，然后保持的状态下没有激发光的光路是由开放的，每个反应容器的列车被间歇地移动时间 和用于存储的第一输出信号的所有这是从用于检测在一段的荧光的光检测器（30）输送时激发光的光路被阻断，以及用于校正的第二输出信号的所有的处理器（43），其被传递 从在期间光检测器当激发光的光路是由开放的，由所述第一输出信号。 此外，测量荧光的强度在化学分析的自动化设备的方法游离缺失盘。

公开(公告)号：WO2017048497A1

公开(公告)日：2017-03-23

申请号：PCT/US2016/049326

申请日：2016-08-29

Applicant: BRIBBLA DYNAMICS LLC

IPC: G01N21/27

CPC classification number: G01N21/274 ,  G01N2201/124 ,  G01N2201/12723 ,  G01N2201/12776

Abstract: Methods and systems for measurement time distribution (1276, 1277, 1278) for referencing schemes are disclosed. The disclosed methods and systems are capable of dynamically changing the measurement time distribution based on the sample signal, reference signal, noise levels, and SNR. The methods and systems are configured with a plurality of measurement states, including a sample measurement state (1282), reference measurement state (1284), and dark measurement state (1286). In some examples, the measurement time distribution scheme can be based on the operating wavelength, the measurement location at the sampling interface, and/or targeted SNR. Examples of the disclosure further include systems and methods for measuring the different measurement states concurrently. Moreover, the systems and methods can include a high-frequency detector to eliminate or reduce decorrelated noise fluctuations that can lower the SNR.

Abstract translation: 公开了用于参考方案的测量时间分布的方法和系统（1276,1277,1278）。 所公开的方法和系统能够基于采样信号，参考信号，噪声电平和SNR来动态地改变测量时间分布。 方法和系统配置有多个测量状态，包括样本测量状态（1282），参考测量状态（1284）和暗测量状态（1286）。 在一些示例中，测量时间分配方案可以基于工作波长，采样接口处的测量位置和/或目标SNR。 本公开的实例还包括同时测量不同测量状态的系统和方法。 此外，系统和方法可以包括高频检测器以消除或减少可降低SNR的去相关噪声波动。

公开(公告)号：WO2016060543A1

公开(公告)日：2016-04-21

申请号：PCT/MY2015/050059

申请日：2015-06-19

Applicant: MIMOS BERHAD

Inventor： LONG SULAIMAN, Tengku Azhar ,  MOHD ZAINAL ARIFFIN, Noorsuriati ,  JAAFAR NG, Mohamad Faisal

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N2201/124

Abstract: The present invention relates to a system (100) and method to extract phase shift of fluorescence signal. The system (100) comprises of a Frequency Generation Unit or FGU (10), a light-emitting diode or LED (20), a sensor element (30), a phase shifter (40), a photo detector (50), a radio frequency (RF) switch (60), a low pass filter (LPF) (70), a trans-impedance amplifier (TIA) (80), and a digital processor (not shown). The photo detector (50) is configured to convert a fluorescence signal from the sensor element (30) into an electrical current signal and also, to multiply the fluorescence signal with either the quadrature signal or the known in-phase signal as selected by the RF switch (60).

Abstract translation: 本发明涉及提取荧光信号相移的系统（100）和方法。 系统（100）包括频率发生单元或FGU（10），发光二极管或LED（20），传感器元件（30），移相器（40），光电检测器（50）， 射频（RF）开关（60），低通滤波器（LPF）（70），跨阻放大器（TIA）（80）和数字处理器（未示出）。 光检测器（50）被配置为将来自传感器元件（30）的荧光信号转换成电流信号，并且还将荧光信号与由RF选择的正交信号或已知的同相信号相乘 开关（60）。

公开(公告)号：WO2015199602A1

公开(公告)日：2015-12-30

申请号：PCT/SE2015/050724

申请日：2015-06-22

Applicant: FLATFROG LABORATORIES AB

Inventor： OHLSSON, Nicklas ,  CHRISTIANSSON, Tomas

IPC: G06F3/042

CPC classification number: G01N21/958 ,  G01N21/59 ,  G01N21/94 ,  G01N2021/945 ,  G01N2201/124 ,  G06F3/0418 ,  G06F3/0421 ,  G06F2203/04109

Abstract: A device implements a method for detecting contamination of an FTIR-based panel. The apparatus generates projection signals representing detection lines that have propagated on a plurality of propagation paths by total internal reflection (TIR) inside a transmissive panel such that contamination on the panel surface causes attenuation (frustration) of at least one of the projection signals. The device generates a transmission value for each detection line in the transmissive panel, and determines the presence of contamination on the surface of the panel by comparing the transmission values ac- cording to at least one of the presented comparison techniques.

Abstract translation: 一种装置实现了一种检测基于FTIR的面板污染的方法。 该装置产生投影信号，其表示通过透射面板内的全内反射（TIR）在多个传播路径上传播的检测线，使得面板表面上的污染导致至少一个投影信号的衰减（沮丧）。 该装置为透射面板中的每个检测线产生透射值，并且通过根据所提供的比较技术中的至少一个比较透射值来确定面板表面上的污染物的存在。

公开(公告)号：WO2013056820A1

公开(公告)日：2013-04-25

申请号：PCT/EP2012/004328

申请日：2012-10-16

Applicant: EPPENDORF AG

Inventor： WILD, Michael ,  JOLIE, Christoph

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/274 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2201/062 ,  G01N2201/124 ,  G01N2201/127

Abstract: The invention is related to a method for the quantitative optical measurement of a char¬ acteristic property of at least one analyte in at least one laboratory sample, in particular for the fluorescence measurement of at least one biochemical or biological sample, the method using a laboratory apparatus, which has at least one light source and at least one detector device, the apparatus utilizing at least sensitivity parameter S, which controls the capability of the laboratory apparatus to detect a signal by means of the at lest one detector device, the method using source light for causing the at least one sample to emit a sample light, and the at least one detector device for detecting sample light and utilizing the at least one sensitivity parameter S to detect the corresponding at least one intensity I of the sample light, the method comprising the steps:- determining at least one reference point (S_ref; I ref); - using at least one first sensitivity parameter S_m1, which is not the same as S_ref, for measuring at least one first intensity I_m1 of sample light as-signed to a first analyte; -determining a quantity Q1, which is a measure for the slope of a line, which is determined by utilizing the at least one reference point (S_ref; l_ref) and the at least one measurement point (S_m1; I_m1 ); using the quantity Q1 for calculating a first analyte value C_m1, which is dependent on Q1 and which is characteristic for a property of the first analyte, in particular for a concentration of the first analyte in the at least one sample, in particular according to the formula Q1 = (I_m1 - l_ref) / (S_m1 - S_ref). The method, further, is related to a laboratory apparatus, which is configured to apply the method according to the invention.

Abstract translation: 本发明涉及用于定量光学测量至少一个实验室样品中至少一种分析物的特性的方法，特别是用于至少一种生物化学或生物样品的荧光测量的方法，使用实验室的方法 装置，其具有至少一个光源和至少一个检测器装置，所述装置至少使用灵敏度参数S，该灵敏度参数S控制实验室装置通过至少一个检测器装置检测信号的能力，所述方法使用 用于使所述至少一个样品发射样品光的源光，以及用于检测样品光的所述至少一个检测器装置，并利用所述至少一个灵敏度参数S来检测所述样品光的相应的至少一个强度I， 方法，包括以下步骤： - 确定至少一个参考点（S_ref; I ref）; - 使用与S_ref不同的至少一个第一灵敏度参数S_m1来测量与第一分析物签名的样本光的至少一个第一强度I_m1; - 确定通过利用所述至少一个参考点（S_ref; l_ref）和所述至少一个测量点（S_m1; I_m1）确定的线的斜率的度量的量Q1; 使用数量Q1来计算取决于Q1的第一分析物值C_m1，其特征在于至少一个样品中的第一分析物的浓度，特别是对于至少一个样品中的第一分析物的浓度，其特征在于第一分析物的性质， 公式Q1 =（I_m1-l_ref）/（S_m1-S_ref）。 该方法还涉及实验室设备，其被配置为应用根据本发明的方法。

公开(公告)号：WO2008155723A1

公开(公告)日：2008-12-24

申请号：PCT/IB2008/052390

申请日：2008-06-18

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  KAHLMAN, Josephus, A., H., M. ,  VERSCHUREN, Coen, A.

Inventor： KAHLMAN, Josephus, A., H., M. ,  VERSCHUREN, Coen, A.

IPC: G01N21/55 ,  G01N21/64

CPC classification number: G01N21/552 ,  G01N21/274 ,  G01N21/4788 ,  G01N21/648 ,  G01N2021/0378 ,  G01N2201/0624 ,  G01N2201/0625 ,  G01N2201/124

Abstract: The invention relates to a method and a microelectronic sensor device for making optical examinations in an investigation region (3). An input light beam (L1) is emitted by a light source (20) into said investigation region (3), and an output light beam (L2) coming from the investigation region (3) is detected by a light detector (30) providing a measurement signal (X). An evaluation unit (40) provides a result signal (R) based on a characteristic parameter (e.g. the intensity) of the input light beam (L1) and the output light beam (L2). Preferably, the input light beam (L1) is modulated with a given frequency (ω) and monitored with a sensor unit (22) that provides a monitoring signal (M). The monitoring signal (M) and the measurement signal (X) can then be demodulated with respect to the monitoring signal, and their ratio can be determined. This allows to obtain a result signal (R) that is largely independent of environmental influences and variations in the light source.

Abstract translation: 本发明涉及一种用于在调查区域（3）进行光学检查的方法和微电子传感器装置。 输入光束（L1）由光源（20）发射到所述调查区域（3）中，来自调查区域（3）的输出光束（L2）由光检测器（30）检测，提供 测量信号（X）。 评估单元（40）基于输入光束（L1）和输出光束（L2）的特性参数（例如强度）提供结果信号（R）。 优选地，以给定频率（ω）调制输入光束（L1），并用提供监视信号（M）的传感器单元（22）监视输入光束（L1）。 监测信号（M）和测量信号（X）可以相对于监视信号被解调，并且可以确定其比例。 这允许获得在很大程度上独立于光源的环境影响和变化的结果信号（R）。

公开(公告)号：KR1020150114465A

公开(公告)日：2015-10-12

申请号：KR1020157017680

申请日：2013-12-04

Applicant: 에스 뻬 트루와 아쉬

Inventor： 오베르띠,실벵 ,  푸르넬,조앙

IPC: G01N21/3577 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/3577 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/124 ,  G01N2201/1242 ,  G01N2201/1247 ,  G01N2201/127 ,  G01N2201/12723

Abstract: 본발명은제품을분석하기위한분광기를제어하기위한방법에관한것이며, 상기방법은광원(LS)의작동을나타내는측정치(LFL, TPL, Ix, Vx)를획득하는단계, 작동측정치에의존하여, 광원의공급전류(LCx)의값, 및/또는광원에의해방사된광빔(LB)의루트상에배치되고분석될제품과상호작용한, 센서(OPS)의광검출기(y)들의적분시간(ITy)의값을결정하고, 적분시간및/또는공급전류값이임계값들사이에있으면, 결정된공급전류값에대응하는공급전류를상기광원에공급하는단계, 결정된적분시간값으로광검출기의적분시간값을조정하는단계, 센서에의해공급된광 세기측정치(MSy)를획득하여, 스펙트럼이형성되는것을가능하게하는단계를포함한다.

公开(公告)号：KR101456873B1

公开(公告)日：2014-10-31

申请号：KR1020107002957

申请日：2008-07-07

Applicant: 베링거 인겔하임 인터내셔날 게엠베하

Inventor： 스퇴켈,페터 ,  비덴벤더,프랑크 ,  크루거토마스

IPC: G01N21/95 ,  B65B1/48 ,  B07C5/342

CPC classification number: G01N21/9508 ,  A61J3/074 ,  B07C5/3425 ,  G01F17/00 ,  G01N15/1463 ,  G01N21/274 ,  G01N2015/0096 ,  G01N2015/1497 ,  G01N2201/0694 ,  G01N2201/124 ,  G01N2201/12753 ,  G06T7/0006 ,  G06T2207/10024

Abstract: 본 발명은 약제의 캡슐 충전을 모니터링하는 방법, 상응하는 충전 방법, 관련된 장치 및 방법과 장치를 제어하는 컴퓨터 프로그램에 관한 것이다. 모니터링 방법에서, 적어도 캡슐 부분을 약제의 소정의 폐쇄 윤곽의 소정의 충전 매스로 충전한 다음, 제1 단계로 충전 작업 후 적어도 캡슐 부분의 충전 매스를 디지털 영상을 사용하여 기록하고, 제2 단계로 디지털 영상 기록으로부터 캡슐 부분의 충전 매스의 윤곽을 측정하고, 제3 단계로 충전 작업을 평가하기 위하여 소정의 윤곽과 비교하여 윤곽을 분석한다. 본 발명은 광학적 시스템을 제어함으로써 보완되는 영상 특성에 대한 외부 영향을 제공한다.

公开(公告)号：JP6038445B2

公开(公告)日：2016-12-07

申请号：JP2011264869

申请日：2011-12-02

Applicant: 東芝メディカルシステムズ株式会社

Inventor： 岩村 佳名子 ,  金山 省一

IPC: G01N21/27

CPC classification number: G01N21/253 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0455 ,  G01N2201/0415 ,  G01N2201/124