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    112.
    发明专利
    未知

    公开(公告)号：BR8802287A

    公开(公告)日：1988-12-13

    申请号：BR8802287

    申请日：1988-05-11

    Applicant: GLAXO INC

    Inventor： PALSON RICHARD CHARLES JULIUS ,  ARMSTRONG JOHN GREIGHTON

    IPC: A61M11/08 ,  A61M15/00

    Abstract: A device for dispensing an aerosol from an aerosol module A includes a cocking device comprising lever 36 and spring 60 for readying it for release of the pressurized aerosol, a sear 64 for retaining the cocking device in a non-operative position following readying and a vane 79 operable by inhalation on the part of a user to disable the sear to thus release the cocking device to effect expulsion of aerosol from the aerosol module.

    113.
    发明专利
    未知

    公开(公告)号：FI884493A0

    公开(公告)日：1988-09-30

    申请号：FI884493

    申请日：1988-09-30

    Applicant: GLAXO INC

    Inventor： PALSON RICHARD CHARLES JULIUS ,  ARMSTRONG JOHN CREIGHTON

    IPC: A61M11/08 ,  A61M15/00 ,  A61M

    Abstract: A device for dispensing an aerosol from an aerosol module A includes a cocking device comprising lever 36 and spring 60 for readying it for release of the pressurized aerosol, a sear 64 for retaining the cocking device in a non-operative position following readying and a vane 79 operable by inhalation on the part of a user to disable the sear to thus release the cocking device to effect expulsion of aerosol from the aerosol module.

    CAMPTOTHECIN DERIVATIVES, METHOD OF PRODUCING THE SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, THEIR USE AND INTERMEDIATE PRODUCTS
    116.
    发明专利
    CAMPTOTHECIN DERIVATIVES, METHOD OF PRODUCING THE SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, THEIR USE AND INTERMEDIATE PRODUCTS 未知

    公开(公告)号：SK323792A3

    公开(公告)日：1998-09-09

    申请号：SK323792

    申请日：1992-10-27

    Applicant: GLAXO INC

    Inventor： LUZZIO MICHAEL J ,  BESTERMAN JEFFREY M ,  EVANS MICHAEL G ,  MYERS PETER L

    IPC: A61K31/435 ,  A61K31/4738 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/47 ,  A61K31/5377 ,  A61K31/541 ,  A61P35/00 ,  A61P43/00 ,  C07D317/66 ,  C07D319/18 ,  C07D491/22 ,  C07D498/22 ,  A61K31/33

    Abstract: The invention relates to water soluble, camptothecin derivatives of formula (I), wherein: n represents the integer 1 or 2; and i) R and R represent independently, hydrogen, lower alkyl, (C PI 1/2 )cycloalkyl, (C PI 1/2 )cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, lower alkoxy lower alkyl; ii) R represents hydrogen, lower alkyl, (C PI 1/2 )cycloalkyl, (C PI 1/2 )cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl or lower alkoxy lower alkyl, and R represents -COR wherein R represents hydrogen, lower alkyl, perhalo-lower alkyl, (C PI 1/2 )cycloalkyl, (C PI 1/2 )cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, lower alkoxy, lower alkoxy lower alkyl; or iii) R and R taken together with the linking nitrogen form a saturated 3 to 7 atom heterocyclic group of formula (IA) wherein: Y represents O, S, CH , NR4 wherein R4 represents hydrogen, lower alkyl, perhalo-lower alkyl, aryl, aryl substituted with one or more lower alkyl, halogen, nitro, amino, lower alkyl amino, perhalo-lower alkyl, hydroxy lower alkyl, lower alkoxy, lower alkoxy lower alkyl groups or; -COR5 wherein R5 represents hydrogen, lower alkyl, perhalo-lower alkyl, lower alkoxy, aryl, aryl substituted with one or more lower alkyl, perhalo-lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl groups; and the pharmaceutically acceptable salts thereof; their use in the treatment of tumors and methods of their preparation.

    DERIVATIVES OF CAMPTOTHECIN, PROCESS OF THEIR PREPARATION INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE COMPRISED
    117.
    发明专利
    DERIVATIVES OF CAMPTOTHECIN, PROCESS OF THEIR PREPARATION INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE COMPRISED 未知

    公开(公告)号：CZ284023B6

    公开(公告)日：1998-07-15

    申请号：CS323792

    申请日：1992-10-27

    Applicant: GLAXO INC

    Inventor： LUZZIO MICHAEL JOSEPH ,  BESTERMAN JEFFREY M ,  EVANS MICHAEL G ,  MYERS PETER LESLIE

    IPC: A61K31/47 ,  A61K31/435 ,  A61K31/4738 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61P35/00 ,  A61P43/00 ,  C07D317/66 ,  C07D319/18 ,  C07D491/22 ,  C07D498/22

    Abstract: The invention relates to water soluble, camptothecin derivatives of formula (I), wherein: n represents the integer 1 or 2; and i) R and R represent independently, hydrogen, lower alkyl, (C PI 1/2 )cycloalkyl, (C PI 1/2 )cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, lower alkoxy lower alkyl; ii) R represents hydrogen, lower alkyl, (C PI 1/2 )cycloalkyl, (C PI 1/2 )cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl or lower alkoxy lower alkyl, and R represents -COR wherein R represents hydrogen, lower alkyl, perhalo-lower alkyl, (C PI 1/2 )cycloalkyl, (C PI 1/2 )cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, lower alkoxy, lower alkoxy lower alkyl; or iii) R and R taken together with the linking nitrogen form a saturated 3 to 7 atom heterocyclic group of formula (IA) wherein: Y represents O, S, CH , NR4 wherein R4 represents hydrogen, lower alkyl, perhalo-lower alkyl, aryl, aryl substituted with one or more lower alkyl, halogen, nitro, amino, lower alkyl amino, perhalo-lower alkyl, hydroxy lower alkyl, lower alkoxy, lower alkoxy lower alkyl groups or; -COR5 wherein R5 represents hydrogen, lower alkyl, perhalo-lower alkyl, lower alkoxy, aryl, aryl substituted with one or more lower alkyl, perhalo-lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl groups; and the pharmaceutically acceptable salts thereof; their use in the treatment of tumors and methods of their preparation.

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