公开(公告)号：MY119778A

公开(公告)日：2005-07-29

申请号：MYPI9402449

申请日：1994-09-14

Applicant: GLAXO INC

Inventor： BATCHELOR KENNETH WILLIAM ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00

Abstract: THE PRESENT INVENTION RELATES TO THE COMPOUND OF FORMULA ( 1 ),(FORMULA 1)ALSO KNOWN AS 17ß-N-(2, 5-BIS(TRIFLUOROMETHYL)PHENYLCARBAMOYL-4-AZA-5(ALPHA)-ANDROST-1-EN-3-ONE, SOLVATES THEREOF, ITS PREPARATION, INTERMEDIATES USED IN ITS PREPARATION, PHARMACEUTICAL FORMULATIONS THEREOF AND ITS USE IN THE TREATMENT OF ANDROGEN RESPONSIVE AND MEDIATED DISEASES.

公开(公告)号：HRP940563A2

公开(公告)日：1997-02-28

申请号：HRP940563

申请日：1994-09-16

Applicant: GLAXO INC

Inventor： BATCHELOR KENNETH WILLIAM ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00

Abstract: The present invention relates to the compound of formula (I), (I) also known as 17 beta -N-(2,5-bis(Trifluoromethyl))phenylcarbamoyl-4-aza-5 alpha -androst-1-en-3-one, solvates thereof, its preparation, intermediates used in its preparation, pharmaceutical formulations thereof and its use in the treatment of androgen responsive and mediated diseases.

公开(公告)号：ZA9407119B

公开(公告)日：1995-05-26

申请号：ZA9407119

申请日：1994-09-15

Applicant: GLAXO INC

Inventor： BATCHELOR KENNETH WILLIAM ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00 ,  C07J ,  A61K ,  C07C

CPC classification number: C07J3/005 ,  C07C235/82 ,  C07C2603/14 ,  C07J41/0066 ,  C07J73/005

公开(公告)号：ZA9407118B

公开(公告)日：1995-05-26

申请号：ZA9407118

申请日：1994-09-15

Applicant: GLAXO INC

Inventor： BATCHELOR KENNETH WILLIAM ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00 ,  C07J ,  A61K ,  C07C

CPC classification number: C07J3/005 ,  C07C235/82 ,  C07C2603/14 ,  C07J41/0066 ,  C07J73/005

公开(公告)号：IS4206A

公开(公告)日：1995-03-18

申请号：IS4206

申请日：1994-09-13

Applicant: GLAXO INC

Inventor： BATCHELOR KENNETH WILLIAM ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61P5/26 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00 ,  C07J75/00

公开(公告)号：PE15095A1

公开(公告)日：1995-06-04

申请号：PE25073794

申请日：1994-09-15

Applicant: GLAXO INC

Inventor： FRYE STEPHEN VERNON ,  BATCHELOR KENNETH WILLIAM

IPC: A61K31/58 ,  C07J41/00 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J73/00

Abstract: SE REFIERE AL COMPUESTO DE FORMULA I CONOCIDO TAMBIEN COMO: 17BETA-N-(2,5-BIS(TRIFLUOROMETIL))FENILCARBAMOIL-4-AZA-5ALFA-ANDROST-1-EN-3-ONA; EL CUAL PODRIA INHIBIR LA ENZIMA 5-ALFA-REDUCTASA HUMANA DE TIPO 1 Y 2; Y SER UTIL EN EL TRATAMIENTO DE ENFERMEDADES COMO HIPERPLASIA PROSTATICA BENIGNA, CANCER DE PROSTATA, ACNE, CALVICIE MASCULINA E HIRSUTISMO, AL BLOQUEAR LA SINTESIS DE DEHIDROTESTOSTERONA A PARTIR DE TESTOSTERONA

公开(公告)号：RO117455B1

公开(公告)日：2002-03-29

申请号：RO9600537

申请日：1994-09-16

Applicant: GLAXO INC RES TRIANGLE PARK

Inventor： BATCHELOR KENNETH WILLIAM ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00

Abstract: The invention relates to the 17 beta-N-(2,5-bis(trifluoromethyl)) phenylcarbamoyl-4-aza-5-alpha-androst-1-en-3-one derivative having the formula (I): as well as to the process for preparing the same, to intermediates, to a pharmaceutical composition containing said derivative and to the corresponding treatment method.

公开(公告)号：IS1726B

公开(公告)日：1999-09-06

申请号：IS4206

申请日：1994-09-13

Applicant: GLAXO INC

Inventor： BATCHELOR KENNETH WILLIAM ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61P5/26 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00 ,  C07J75/00

公开(公告)号：ZA947119B

公开(公告)日：1995-05-26

申请号：ZA947119

申请日：1994-09-15

Applicant: GLAXO INC

Inventor： BATCHELOR KENNETH WILLIAM ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00 ,  C07J ,  A61K ,  C07C

Abstract: The present invention relates to the compound of formula (I), (I) also known as 17 beta -N-(2,5-bis(Trifluoromethyl))phenylcarbamoyl-4-aza-5 alpha -androst-1-en-3-one, solvates thereof, its preparation, intermediates used in its preparation, pharmaceutical formulations thereof and its use in the treatment of androgen responsive and mediated diseases.

公开(公告)号：ZA947118B

公开(公告)日：1995-05-26

申请号：ZA947118

申请日：1994-09-15

Applicant: GLAXO INC

Inventor： BATCHELOR KENNETH WILLIAM ,  FRYE STEPHEN VERNON

IPC: A61K31/58 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00 ,  C07J ,  A61K ,  C07C

Abstract: The present invention relates to the compound of formula (I), (I) also known as 17 beta -N-(2,5-bis(Trifluoromethyl))phenylcarbamoyl-4-aza-5 alpha -androst-1-en-3-one, solvates thereof, its preparation, intermediates used in its preparation, pharmaceutical formulations thereof and its use in the treatment of androgen responsive and mediated diseases.